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Dapagliflozin+Vildagliptin

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Molecule Summary

Uses
Type 2 diabetes mellitus
Therapy
Anti-Diabetic
Side Effects
Low blood sugar levels, nausea, vomiting, diarrhoea, loss of appetite, headache, dizziness, shakiness
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Molecule Description

Dapagliflozin+Vildagliptin is an anti-diabetic medication used to manage type 2 diabetes mellitus in individuals whose blood sugar levels are not adequately controlled by metformin alone. Dapagliflozin+Vildagliptin contains a combination of vildagliptin and dapagliflozin as active ingredients. Take this medicine in the precise dose and duration as directed by your doctor. Do not exceed the prescribed dose, and do not cease taking this medicine without your doctor's advice. Before using Dapagliflozin+Vildagliptin, inform your doctor if you are pregnant, planning to become pregnant, breastfeeding, and about your complete medical history. Additionally, disclose all medications and supplements you are taking. It is advisable to make certain lifestyle modifications, such as exercising regularly, maintaining a balanced diet, avoiding alcohol, and quitting smoking while taking Dapagliflozin+Vildagliptin to achieve better control of your blood sugar levels.

Uses

Dapagliflozin+Vildagliptin is an anti-diabetic medication that is used to treat Type 2 diabetes mellitus in adults along with diet and exercise.

Contraindications

When should one not use Dapagliflozin+Vildagliptin

  • If you are allergic to vildagliptin, dapagliflozin or any other ingredient of Dapagliflozin+Vildagliptin.

Side effects

Common side effects of this drug are:

  • Headache
  • Dizziness
  • Nausea
  • Low blood sugar
  • Shakiness

Precautions and Warnings

Pregnancy

Pregnancy

There is limited information on the use of Dapagliflozin+Vildagliptin in pregnancy. This medicine should not be used in pregnancy unless recommended by your doctor.

Breast Feeding

Breast Feeding

There is no information if Dapagliflozin+Vildagliptin passes into human breast milk. Dapagliflozin+Vildagliptin is not recommended for use in breastfeeding women.

Driving

Driving

Dapagliflozin+Vildagliptin has little or no influence on driving ability. If you experience any side effects after taking this medicine that may affect your ability to drive safely, it is advised to avoid driving.

Alcohol

Alcohol

No, alcohol should not be consumed with Dapagliflozin+Vildagliptin as this may increase the risk of lactic acidosis.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You are taking other anti-diabetic medicines like sulphonylureas. If you are not sure what these medicines are, please confirm with your doctor.
  • You have kidney disease or are on dialysis.
  • You have liver disease or heart failure.
  • You had or have a disease of the pancreas.
  • You develop blisters or ulcers on your foot while taking this medicine. Talk to your doctor immediately.
  • You are below 18 years of age.

Mode of Action

How Does It Work?

  • Dapagliflozin+Vildagliptin contains a combination of vildagliptin and dapagliflozin as active ingredients. Vildagliptin indirectly enhances the activity of certain chemicals in the body that raise insulin levels following a meal. Dapagliflozin inhibits a specific protein in the kidneys known as sodium-glucose co-transporter 2 (SGLT-2), which is responsible for reabsorbing glucose (sugar) from urine back into the blood. This process facilitates the elimination of sugar through urine, thus lowering blood sugar levels.

Interactions

Interactions with other medicines

  • Inform your doctor about all other medicines, herbs or supplements that you are currently taking or might take to avoid any possible interaction.
  • The use of Dapagliflozin+Vildagliptin with diuretics like furosemide and hydrochlorothiazide (used to manage fluid accumulation) may increase the risk of dehydration and low blood pressure.
  • This medicine, when used together with insulin and insulin secretagogues (sulphonylurea), may cause extremely low blood sugar levels.
  • Dapagliflozin+Vildagliptin taken along with ACE inhibitors may increase the risk of angioedema (painless swelling under the skin).
  • The effectiveness of this medicine may be decreased when combined with thiazides (used to manage fluid retention), corticosteroids (used to manage inflammation), thyroid products, and sympathomimetics (nasal decongestants for treating allergies and conjunctivitis).

Dosage

Overdose

Symptoms of overdose of Dapagliflozin+Vildagliptin include muscle pain, fever, swelling, and tickling/pricking sensation.

Missed a Dose

You should never miss your blood sugar medicines as it may lead to high blood sugar and symptoms associated with it. However, if you missed any dose of the medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

Frequently Asked Questions (FAQs)

Dapagliflozin+Vildagliptin should not be used in pregnancy unless prescribed by your doctor. Your doctor will recommend the best way to control your blood sugar while you are pregnant.

Individuals with Type 2 diabetes mellitus should regularly check their blood sugar levels, stay hydrated, maintain a healthy weight, have an active lifestyle and eat a balanced diet. They should avoid alcohol intake, sedentary lifestyle and junk food.

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