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Daclatasvir

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Molecule Summary

Uses
Hepatitis C virus (HCV)
Therapy
Drugs For Hepatitis C
Side Effects
Slow heart rate, fainting, dizziness
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Molecule Description

Daclatasvir is a prescription medicine used for the treatment of long-term hepatitis C infection (genotype 1 or genotype 3) in adults, usually along with sofosbuvir or with sofosbuvir and ribavirin. It works by blocking a special protein in the hepatitis C virus called NS5A, which is essential for the virus to multiply and spread. By stopping this protein from working, the medicine helps reduce the amount of virus in your body and supports the clearing of the infection. You should not take this medicine if you are allergic to daclatasvir or any of its ingredients. It is also not suitable if you are taking certain medicines for epilepsy (such as phenytoin or carbamazepine), tuberculosis (such as rifampin), or the herbal remedy St. John's wort. Some medicines can make Daclatasvir less effective by breaking it down faster in the body, so your doctor will check your other medications before starting treatment. Like all medicines, Daclatasvir can cause side effects. Some people may experience a slow heartbeat, dizziness, fainting, tiredness, shortness of breath, chest pain, or confusion. These symptoms may also be related to the medicines it is taken with, such as sofosbuvir or ribavirin. If you feel unusually weak, lightheaded, or notice troubling symptoms, inform your doctor promptly. During treatment, let your doctor know if you have ever had hepatitis B, as hepatitis B can become active again during or after hepatitis C treatment. Watch out for signs like yellowing of the skin or eyes, dark urine, or extreme tiredness, and seek medical advice if these occur. This medicine can be taken with or without food, but try to take it at the same time every day for the best results. Do not take more than prescribed, and follow your doctor's instructions closely to get the maximum benefit from the treatment.

Uses

Daclatasvir is a prescription medicine used to treat chronic (lasting a long time) hepatitis C genotype 1 or genotype 3 infection in adults, along with sofosbuvir or with sofosbuvir and ribavirin.

Contraindications

When should one not use Daclatasvir

  • If you are allergic to daclatasvir or any other ingredients of Daclatasvir.
  • If you take medicines for epilepsy, such as phenytoin or carbamazepine.
  • If you take medicines for tuberculosis, such as rifampin.
  • If you use the herbal remedy St. John's wort (also called Hypericum perforatum).
  • If you are on any other medicine that strongly reduces the effect of Daclatasvir by speeding up how it is broken down in your body.

Side effects

Common side effects of this drug are:

  • Slow heart rate
  • Fainting or near-fainting
  • Dizziness or lightheadedness
  • Tiredness
  • Shortness of breath
  • Chest pain
  • Confusion

Precautions and Warnings

Pregnancy

Pregnancy

No information is available. If daclatasvir and sofosbuvir are administered with ribavirin, the combination regimen is contraindicated in pregnant women and in men whose female partners are pregnant. Refer to the ribavirin prescribing information for more information on use in pregnancy.

Breast Feeding

Breast Feeding

It is unknown whether Daclatasvir or its metabolites are excreted in human milk. Consult your doctor before taking Daclatasvir while breastfeeding.

Driving

Driving

Daclatasvir is unlikely to affect the ability to drive and use machines. When driving vehicles or operating machinery, it is essential to consider that dizziness or confusion may occur during treatment.

Alcohol

Alcohol

No known information is available.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have ever had hepatitis B, as treatment for hepatitis C can sometimes make hepatitis B become active again.
  • You notice yellowing of your skin or eyes, dark urine, or extreme tiredness, as these may be signs of liver problems.
  • You are taking medicines that weaken your immune system or chemotherapy, because these may increase the risk of hepatitis B becoming active again.
  • You have sudden changes in your health during or after hepatitis C treatment, as hepatitis B reactivation can happen even after the treatment ends.
  • You have blood test results showing past hepatitis B infection, even if you feel well, as monitoring may be needed.

Mode of Action

How Does It Work?

  • Daclatasvir works by blocking a protein in the hepatitis C virus called NS5A. This protein is essential for the virus to multiply and assemble new virus particles.
  • By stopping NS5A from working, daclatasvir reduces the amount of virus in the body and helps the infection clear.

Dosage

Overdose

If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.

Missed a Dose

If you miss any dose of Daclatasvir, take it as soon as you remember with food. However, if it is time for the next dose, then skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Frequently Asked Questions (FAQs)

It is not known if Daclatasvir is safe and effective in children under 18 years of age. Consult your doctor before giving it to children.

Yes, if you have had hepatitis B before, it can become active again. Watch for symptoms like yellowing of skin or eyes, dark urine, or extreme tiredness.

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