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Cyproterone+Ethinylestradiol

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Molecule Summary

Uses
Hirsutism & alopecia
Therapy
Drugs For Polycystic Ovarian Disease
Side Effects
Nausea, stomach ache, weight gain, headache, feeling low
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Molecule Description

Cyproterone+Ethinylestradiol is a hormonal preparation that is used to treat androgenic hormone-dependent disorders such as acne, alopecia (hair loss or baldness), hirsutism (excessive growth of coarse and dark hair in females) and irregular periods. It is a combination medicine containing cyproterone and ethinylestradiol. Androgen is a male sex hormone that is produced in a small amount in females under normal conditions. It is essential for maintaining some reproductive functions, bone mass and other physiological behaviours in women. Androgen-dependent disorders occur due to the increased levels of the male sex hormone (androgen) in females. Cyproterone+Ethinylestradiol should be taken as directed by the doctor and in doses and duration as prescribed. Before using this medicine, inform the doctor if you are pregnant, planning a pregnancy or breastfeeding and about your detailed medical history.

Uses

Cyproterone+Ethinylestradiol is used to treat symptoms of polycystic ovary syndrome (PCOS), such as acne, excessive hair growth (hirsutism), and irregular periods.

Contraindications

When should one not use Cyproterone+Ethinylestradiol

  • If you are using any hormonal contraceptive pills.
  • If you are allergic to ethinylestradiol or cyproterone or any other ingredients of Cyproterone+Ethinylestradiol.
  • If you have or had a blood clot in your leg (thrombosis) or lung (pulmonary embolism).
  • If you had a heart attack or stroke.
  • If you have a history of getting migraine attacks.
  • If you have an eye-related disorder or vision problem.
  • If you suffer from sickle cell anaemia (abnormal red blood cells).
  • If you have a lipid metabolism disorder (high blood cholesterol or fats).
  • If you have or had breast cancer.
  • If you suffer from abnormal vaginal bleeding of unknown cause.
  • If you have any liver disease or liver tumours, or hepatitis C infection.

Side effects

Common side effects of this drug are:

  • Nausea
  • Stomach ache
  • Weight gain
  • Headache
  • Feeling low
  • Mood swings
  • Breast pain
  • Breast tenderness
  • Rashes
  • Vomiting

Precautions and Warnings

Pregnancy

Pregnancy

Do not take Cyproterone+Ethinylestradiol if you are pregnant or planning to have a baby. If pregnancy is detected during the treatment, discontinue the medicine and inform your doctor.

Breast Feeding

Breast Feeding

Do not take Cyproterone+Ethinylestradiol while you are breastfeeding. This medicine can alter milk production in lactating women. Please consult your doctor before using it.

Driving

Driving

There is no information available on the effect of Cyproterone+Ethinylestradiol on the driving abilities of an individual.

Alcohol

Alcohol

No information is available on interactions of Cyproterone+Ethinylestradiol when taken with alcohol, consult your doctor or pharmacist for further information.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You are suffering from mood or any brain-related disorders.
  • You have varicose veins or inflamed veins (phlebitis).
  • You have diabetes, high blood pressure (hypertension) or fits (epilepsy).
  • You have an inherited form of deafness known as otosclerosis.
  • You have nervous system problems like multiple sclerosis.
  • You have cramps caused by calcium deficiency (tetany).
  • You have a movement disorder called Sydenham's chorea.
  • You are suffering from a condition like asthma, migraine, gallstones
  • You have an immune system-related chronic inflammatory disease known as Systemic Lupus Erythematosus (SLE).
  • You have an inherited disorder of haemoglobin metabolism (porphyria).
  • You have breast problems, past or present, or your family has had breast cancer.
  • You have any heart or circulation problems or has anyone in your family had any illness caused by blood clots, heart attack or stroke at a young age.
  • You have kidney diseases, liver-related disorders, or you are overweight (obese).

Mode of Action

How Does It Work?

  • Cyproterone+Ethinylestradiol has anti-androgenic action. Ethinylestradiol is a synthetic female sex hormone, and it reduces the levels of male sex hormones (androgens).
  • Cyproterone blocks the actions of male sex hormones (androgens) and reduces the number of male sex hormones produced by the body.

Interactions

Interactions with other medicines

  • Women taking Cyproterone+Ethinylestradiol for a short duration should use additional physical barriers for contraception during the treatment and 28 days after their discontinuation.
  • Women taking this medicine for long-term treatment should use other means of contraception. Discuss with your doctor for more information.
  • Antibiotics (Ampicillin, Rifampicin, and Tetracycline), Antifungals (such as Griseofulvin), and medicines used for brain-related disorders (Phenytoin, Primidone, Phenobarbitone, Barbiturates), and anti-viral medicines (Ritonavir and Nelfinavir) should be used cautiously.
  • Etoricoxib used in arthritis can raise the levels of Cyproterone+Ethinylestradiol in the body. Cyproterone+Ethinylestradiol can increase the levels of cyclosporin or decrease the levels of lamotrigine. Discuss with your doctor if you are taking any of these medicines.
  • Cyproterone+Ethinylestradiol may interact with several medicines. Please inform your doctor about all the medicines, supplements or herbal medicines you are taking while on treatment with this medicine.

Dosage

Overdose

Overdose of Cyproterone+Ethinylestradiol may lead to severe health complications. Do not take more than the recommended dosage. Taking an excessive dose of this medicine may lead to prolonged side effects. In case of an overdose, immediately contact your doctor or reach out to a nearby healthcare centre.

Missed a Dose

If you have missed taking any dose of Cyproterone+Ethinylestradiol, take it as soon as you remember. However, if it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.

Frequently Asked Questions (FAQs)

Yes, weight gain is one of the common side effects of this medicine. It is mostly due to fluid retention and should return to normal after discontinuation of the treatment.

Cyproterone+Ethinylestradiol has an anti-androgenic action. It reduces the production and circulating levels of male sex hormones and helps in controlling diseases associated with increased androgen levels.

No, Cyproterone+Ethinylestradiol is not birth control or the contraceptive pill.

Cyproterone+Ethinylestradiol is intended to treat symptoms related to excessive male hormones like hair loss, acne and irregular periods. Please consult your doctor before use.

You can take Cyproterone+Ethinylestradiol as long as the doctor has prescribed you. It usually takes a few weeks to show its full effect. However, it is important to finish the full course of treatment to see its full benefit. Do not stop the treatment midway, even if you see improvement in symptoms. Also, if you do not see any improvement, inform the doctor but do not take it endlessly on your own.

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