Chlorpheniramine Maleate+Phenylephrine Hydrochloride
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Molecule Summary
| Uses | Cold, allergic rhinitis |
| Therapy | Cough Cold Preparation |
| Side Effects | Drowsiness, headache, vomiting, weakness |
Medicines
available
19k pincodes
Molecule Description
Chlorpheniramine Maleate+Phenylephrine Hydrochloride contains a combination of chlorpheniramine and phenylephrine. Chlorpheniramine is an antiallergic and Phenylephrine is a decongestant. It is used for temporary relief in common cold and allergic rhinitis. It helps in improving symptoms like runny and stuffed nose, sneezing and throat irritation. This medicine should not be used in patients with heart-related problems. You should take Chlorpheniramine Maleate+Phenylephrine Hydrochloride as advised by your doctor for maximum benefits and avoid using it for a prolonged duration when not required.
Uses
Chlorpheniramine Maleate+Phenylephrine Hydrochloride is used for the symptomatic treatment of common cold and allergic rhinitis.
Contraindications
When should one not use Chlorpheniramine Maleate+Phenylephrine Hydrochloride
- If you are allergic to Chlorpheniramine or Phenylephrine or any of the ingredients of Chlorpheniramine Maleate+Phenylephrine Hydrochloride.
- If you have taken medicines for brain disorders such as rasagiline in the last 14 days
- If you are suffering from high blood pressure or heart disease
- If you have diabetes, increased pressure inside the eyes (glaucoma)
- If you are suffering from an overactive thyroid gland and breathing problems like bronchitis
- If you experience difficulty in urination due to enlarged prostate gland
Side effects
Common side effects of this drug are:
- Drowsiness
- Headache
- Vomiting
- Weakness
- Incoordination
- Dizziness
- Excitation
- Confusion
- Increased blood pressure
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You are already taking medicines for psychiatric illness, as it can enhance drowsiness
- You are experiencing drowsiness, nervousness.
- You don't feel any improvement in your symptoms within a week.
- You are pregnant or breastfeeding.
- You have asthma or any airway obstruction problems.
- You have a kidney or liver disease.
- You have a history of fits or seizures.
- You have a history of tumours in the adrenal gland.
- You have a blockage in your stomach and intestine.
Mode of Action
How Does It Work?
- Chlorpheniramine Maleate+Phenylephrine Hydrochloride works by the combined action of its two components chlorpheniramine and phenylephrine. Chlorpheniramine acts by blocking the action of histamine a natural substance produced by the body during an allergic reaction and improves allergic symptoms like sneezing, watery eyes and throat irritation.
- Phenylephrine acts as a vasoconstrictor, it shrinks or constricts the blood vessels in the nasal passage and improves congestion.
Interactions
Interactions with other medicines
- Medicines used to treat brain disorders or psychiatric illness should not be used with Chlorpheniramine Maleate+Phenylephrine Hydrochloride as it can lead to a risk of heart-related side effects or increased blood pressure.
- Chlorpheniramine Maleate+Phenylephrine Hydrochloride can reduce the effectiveness of high blood pressure medicines and can increase blood pressure abruptly.
- Chlorpheniramine Maleate+Phenylephrine Hydrochloride should not be taken along with medicines used to treat heart failures, such as digoxin, as it can increase the risk of irregular heartbeat or heart attack.
- Phenytoin and ergot-containing medicines should not be consumed along with Chlorpheniramine Maleate+Phenylephrine Hydrochloride as it can lead to toxicity.
- Other medicines like medicines to induce sleep or anti-anxiety medicines and certain painkillers should be used with caution as they can induce sedation.
- Discuss with your doctor any other medicine, herbal preparation and supplements you are taking currently to avoid any possible drug interactions.
Dosage
Overdose
- Symptoms of overdose of Chlorpheniramine Maleate+Phenylephrine Hydrochloride may include irregular heartbeat, hallucinations, fits or you may sometimes pass out.
- If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If you missed any dose of Chlorpheniramine Maleate+Phenylephrine Hydrochloride, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.
Frequently Asked Questions (FAQs)
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References:
- National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 5281068, Chlorpheniramine Maleate.[cited 11 Jun 2026].
- National Center for Biotechnology Information (2025). PubChem Compound Summary for, Acetaminophen; Chlorpheniramine maleate; Phenylephrine Hydrochloride. [cited 11 Jun 2026].
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