Bendamustine

Uses	Blood cancer, Non-Hodgkins Lymphoma, Multiple Myeloma
Therapy	Anti-Neoplastic
Side Effects	Anaemia, low blood platelets, decreased white blood cell count, infection, fatigue, nausea, vomiting

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Molecule Description

Bendamustine is an injectable used for Non-Hodgkin's Lymphoma (NHL) and other lymphatic cancers.

Uses

Non-Hodgkin lymphoma (NHL)
Blood cancer
Multiple myeloma

Contraindications

When should one not use Bendamustine

Hypersensitivity reactions

Side effects

Common side effects of this drug are:

Low blood platelets
Anaemia
Decreased white blood cell count
Nausea
Vomiting
Infection
Fatigue

Precautions and Warnings

Pregnancy

Bendamustine should not be used during pregnancy because there is clear evidence that it poses a risk to the growing foetus.

Breast Feeding

Using Bendamustine during breastfeeding is risky. This medicine can induce toxicity in the newborn, according to the data.

Driving

Bendamustine may cause fatigue. If you feel tired or unwell, do not drive or use machines. Consult your doctor if unsure.

Alcohol

No interaction studies are available for alcohol consumption with Bendamustine.

Other General Warnings

Talk to your doctor if

You have allergy to components of Bendamustine
You have severe liver, kidney or heart disease
You have a history of cardiovascular, lung, kidney or liver diseases
You have myelosuppression, tumour lysis syndrome
You have any cancer or history of cancer
You are at increased risk of infections including pneumonia, hepatitis B, tuberculosis, and sepsis

Mode of Action

How Does It Work?

Bendamustine is a cancer-fighting medication. It works by destroying the cancer cells' genetic material (DNA and RNA). Their growth and multiplication are halted as a result of this. By preventing the activity of other chemicals essential for cancer to grow and spread, Bendamustine helps to limit cancer development and spread.

Interactions

Interactions with other medicines

The metabolism of Bendamustine decreases when taken with Albendazole
The interaction of Norfloxacin and Bendamustine can cause fever, chills and skin rashes
Clozapine with Bendamustine can cause exaggerated itching, skin reactions, swelling of the face, tongue

Interactions with food items

Coffee and caffeine-based items should be avoided when taking this medication due to the increased risk of severe adverse effects. Any flu-like symptoms, such as lethargy, dizziness, sore throat, body aches, unusual bleeding, or bruises, should be immediately reported to your oncologist.

Dosage

Overdose

As this medicine is given by a skilled healthcare practitioner in a hospital setting the risk of an overdose is quite minimal. If an overdose is suspected, the oncologist will initiate emergency medical treatment.

Missed a Dose

As this medicine is given by a skilled practitioner in a clinical setting, the chances of missing a dose are rare. If you miss a planned dosage of this medicine, contact your doctor as soon as possible for further instructions.

Frequently Asked Questions (FAQs)

Yes. Bendamustine is safe when used at the recommended doses and for the period recommended by the oncologist.

Yes. Bendamustine is a vesicant, which means that if it leaks during administration, it can cause substantial harm to the skin and underlying fat.

Yes. Hair loss and constipation are two of Bendamustine's most prevalent adverse effects.

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