Azathioprine

Molecule Description

Azathioprine is an ‘Immunosuppressant,’ which is used to treat organ rejection

after transplantation and certain disorders that cause over activity of the immune system.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Azathioprine

Prevention of rejection of the organ by the immune system after transplantation surgery in patients who received organs such as kidney, liver, heart, lung or pancreas
Severe joint pains (rheumatoid arthritis) which is not responding to other treatments
Severe form of diseases that affect the lining of the intestines or cause ulcers (Crohn's disease, ulcerative colitis)
Conditions due to over-reactive immune system – skin rashes and muscle weakness (dermatomyositis)
An immune reaction that affects joints, skin, blood cells, brain, kidneys, etc. (systemic lupus erythematosus)
Liver disease due to immune disorders (auto-immune chronic active hepatitis)
Destruction of red blood cells (refractory warm auto-immune hemolytic anemia)
Easy bruising and purple spots on skin due to low platelet counts (chronic refractory idiopathic thrombocytopenic purpura)
Diseases of the arteries (polyarteritis nodosa)

Contraindications of Azathioprine

When should one not use Azathioprine

Allergy to Azathioprine or any of the components of the medicine or any other medicine of the same class
Severe infections
Severe liver or bone marrow diseases
Infections of the pancreas (pancreatitis)
Live vaccines (BCG or smallpox)

Side effects of Azathioprine

Common side effects of this drug are:

Reduction in bone marrow function (decrease in red blood cells, white blood cells and platelets)
Any viral, bacterial or fungal infections (due to decreased white blood cells)
Tiredness, shortness of breath, headache, feeling dizzy (due to decreased red blood cells), Liver problems with symptoms like pale stools, itching, jaundice (uncommon)
Stomach problems (loose motions, stomach pain, constipation, feeling sick), hair loss, sensitivity to skin, severe liver damage or cancers of the blood, lymph (a fluid made up of white blood cells) or...
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Severe allergic reactions causing swelling of the skin of the face, breathing difficulty with or without rashes and itching, skin blistering, muscle and joint weakness, extreme tiredness, easy bruisin...
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Precautions and Warnings of Azathioprine

Pregnancy

Can I take Azathioprine during pregnancy?

Azathioprine has the potential to harm the unborn baby and should be used in pregnancy only if the patient requires the medicine, and it cannot be substituted.

Breast Feeding

Can I take Azathioprine while breastfeeding?

It is advised to avoid Azathioprine in breast-feeding women, as it is secreted in the breastmilk and can harm the baby.

Driving

Can I drive if I have consumed Azathioprine?

Adequate data is not available. But as Azathioprine is used mostly in severe and delicate conditions, extreme caution is recommended, and it is better to avoid driving.

Alcohol

Can I consume alcohol with Azathioprine?

Alcohol does not interact directly with Azathioprine and limited consumption of alcohol is permissible. But it is important to remember that alcohol affects the immune system and delays recovery.

Other General Warnings

Talk to your doctor if

A rare genetic disease that causes increased levels of uric acid in the body (Lesch-Nyhan syndrome)
Kidney or liver diseases
Azathioprine can increase the risk of tumors of the skin and the lymph nodes (avoid direct contact with light and using multiple immunosuppressant medicines together)
Excessive activation of white blood cells in patients with joint pains (macrophage activation syndrome)
Be watchful of any new growths or lumps on the skin or inside the body

Mode of Action of Azathioprine

How Does It Work?

Azathioprine works by reducing the production of some types of white blood cells (which cause the immune system to overreact in certain conditions) and thus suppress the immune system; this will decre...

Interactions of Azathioprine

Interactions with other medicines

Medicines for gout (Allopurinol, Oxipurinol, Thiopurinol)
Muscle relaxants given during anesthesia (Succinylcholine and Tubocurarine)
Medications used to prevent blood clots (Warfarin etc.)
Penicillamine ( treats rheumatoid arthritis)
Co-trimoxazole (to treat infections)
Captopril, Furosemide (treats high blood pressure)
Cimetidine (reduces stomach acidity)
Indomethacin (pain killer)
Certain medicines used to treat immune system disorders (TPMT inhibitors - Olsalazine, Mesalazine, Sulfasalazine)
Avoid live vaccines such as BCG, smallpox, or yellow fever

Interactions with food items

Azathioprine must be taken with meals, along with a glass of water.

Dosage of Azathioprine

Overdose

Occasional overdose may not be life-threatening. But the common symptoms of high overdose are low blood count, fever, throat ulcers, increased infections, so you should seek medical attention without ...

Missed a Dose

If you remember within 12 hours of your dose being due, then take your dose as usual. If it is more than 12 hours since your dosage is due, do not take it, and continue with your next dosages at the r...

Q: Are there any precautions I need to take before using Azathioprine?

A: Azathioprine is used for severe and delicate conditions involving the immune system. Hence, care and caution is warranted through the course of treatment with this medicine. As it causes changes in blood cells and platelets, regular blood tests may be required. Avoid direct exposure to the sun, wear protective clothing, and use sunscreen lotions. If you take multiple Immunosuppressants, it will increase your risk further. Azathioprine increases the risk of cancer. Do not stop taking medicine suddenly, as it may cause a flare-up of the immune system and lead to harmful reactions. Do not self-medicate with Azathioprine. Inform your doctor if you do not feel like taking this medicine. He will decrease the dose gradually and use other alternatives. Do not take any vaccines without the knowledge of your doctor.

Q: Does Azathioprine cause cancer?

A: Azathioprine does not cause cancer. But it can increase your risk for certain cancer of the skin or the immune system. You can take precautions as illustrated above (protective clothing, avoiding exposure to sun, etc.) and keep your risk to a minimum. Patients do take Azathioprine for long periods with excellent results. Exercise caution as there is a chance of risk due to its actions on the bone marrow causing a decrease in blood cell counts. You should do blood and kidney tests regularly for close monitoring. If you can be a bit careful, there is no need to avoid this medicine.

References

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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