What is the use of Alpelisib?

Alpelisib

Uses	Advanced or metastatic breast cancer
Therapy	Anti-Neoplastic
Side Effects	Nausea, Vomiting, Decreased appetite, Diarrhoea or colitis, Abdominal pain, Rash

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Molecule Description

Alpelisib is an anticancer medicine. It is a PI3K inhibitor used to treat breast cancer in patients who are HR-positive, HER2-negative, diagnosed with PIK3CA-mutated, advanced or metastatic breast cancer. It is given in conjunction with another medication known as fulvestrant and is appropriate for both postmenopausal women and men. Before the treatment, your doctor may give you medication to prevent nausea and vomiting. During treatment and for one week after the last dose, women should use an effective form of birth control. Male patients with female partners should use effective birth control during treatment as well as for one week after the last dose. If you have kidney disease, lung disease or breathing problems, or diabetes, tell your doctor. Do not breastfeed while taking this medication or for 1 week after the last dose.

Uses

Advanced or metastatic breast cancer

Contraindications

When should one not use Alpelisib

Allergy to any of the components
Pregnancy
Breastfeeding

Side effects

Common side effects of this drug are:

Nausea
Vomiting
Decreased appetite
Diarrhoea or colitis
Abdominal pain
Rash
Tiredness or weakness
Weight loss
Mouth sores
Hair loss
Changes in blood test results

Precautions and Warnings

Pregnancy

Alpelisib is not recommended during pregnancy and in women of childbearing potential not using contraception.

Breast Feeding

Patients receiving Alpelisib should not breastfeed.

Driving

Alpelisib may have a minor impact on your ability to drive and operate machinery. Patients should exercise caution when driving or operating machinery if they experience fatigue or blurred vision while taking Alpelisib.

Alcohol

No information is available on the interactions between Alpelisib and alcohol.

Other General Warnings

Talk to your doctor if

You are allergic to any of the ingredients
You have a history of diabetes
You had or have a skin rash, blisters, redness
You are pregnant or plan to become pregnant, as it may cause harm to an unborn baby.
You are taking any other medications, including prescription, over-the-counter, or herbal supplements, as they may affect each other, causing side effects
Use effective birth control during the treatment and till 1 week after the last dose.
Do not breastfeed during the treatment and till 1 week after the last dose

Mode of Action

How Does It Work?

Alpelisib selectively inhibits the activity of PI3K enzyme involved in various biological processes, including proliferation, survival, differentiation, and metabolism. Alpelisib targets this enzyme that appears to be mutated, leading to hyperactivation and cancer cell growth. Thus, Alpelisib results in the inhibition of the growth and survival of cancer cells.

Dosage

Overdose

In the event of an overdose, report to your doctor immediately.

Missed a Dose

Report to your doctor immediately. Do not take extra doses to compensate for missed doses.

Frequently Asked Questions (FAQs)

Alpelisib is prescribed for the treatment of specific forms of breast cancer. These include hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to other organs, as well as breast cancer with a specific genetic mutation called PIK3CA mutation.

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