Piperacillin+Tazobactam

Uses	Bacterial infections
Therapy	Antibiotic
Side Effects	Nausea, vomiting, indigestion, headache, pain, redness and swelling at the injection site

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Molecule Description

Piperacillin+Tazobactam is a combination of piperacillin, an antibiotic that works by killing the bacteria responsible for infections, and tazobactam. Certain bacteria develop an enzyme (beta-lactamases) that can destroy piperacillin as a resistance mechanism. Tazobactam blocks this enzyme.

Uses

Treatment of serious and complicated infections caused by bacteria such as stomach and abdominal infection, skin and soft tissue infections, diabetic foot infections due to diabetes and pneumonia. It is to be used only when an infection cannot be controlled by other antibiotics.

Contraindications

When should one not use Piperacillin+Tazobactam

If you are allergic to Piperacillin and Tazobactam or any of the ingredients of this medicine.
If you have a history of severe allergic reactions to any other antibiotic like Cephalosporins, Monobactam and Carbapenem.

Side effects

Common side effects of this drug are:

Diarrhoea
Constipation
Nausea
Vomiting
Indigestion
Stomach pain
Fever
Anaemia
Fungal infection (candidiasis)
Headache
Sleeplessness
Rashes
Itching
Inflammation and swelling at the injection site

Precautions and Warnings

Pregnancy

It is not advisable to take this medicine during pregnancy as it passes the placental barrier. However, it can be given to you by your doctor if required after assessing the benefits over risks. Consult your doctor if you are pregnant, think you may be pregnant or are planning to have a baby.

Breast Feeding

The components of this medicine pass into breastmilk and are known to cause fungal infections of the mouth and diarrhoea in babies. Consult your doctor if you are breastfeeding, your doctor will tell you about the use of this medicine after assessing the benefits over risks.

Driving

No information is available on the effect of this medicine on the ability to drive or use machines. However, if you experience any side effects like pain or swelling at the site of injection, do not drive.

Alcohol

No information is available on the interaction of this medicine with alcohol. However, consuming alcohol may exaggerate the side effects of this medicine. Thus, it is not advisable to consume alcohol when you are taking this medicine.

Other General Warnings

Talk to your doctor if

You have a history of allergic reactions to Penicillin, Cephalosporins, Carbapenems.
You develop serious skin disorders like painful rashes along with flu.
You have diarrhoea and pus in your stool after taking this medicine, immediately stop the medicine and report to your doctor.
You experience bleeding disorders or taking blood-thinning medicines like Warfarin.
You experience fits or convulsions.
You have problems with kidney function.
You have weakness, fatigue, muscle cramps or low levels of potassium.

Mode of Action

How Does It Work?

Piperacillin+Tazobactam acts by killing the bacteria responsible for infections. However, bacteria make an enzyme (beta-lactamases) which can destroy piperacillin. Tazobactam blocks this enzyme so that piperacillin can work.

Interactions

Interactions with other medicines

Medicines used to relax the muscles during surgery like Vecuronium.
Close monitoring of blood function is required if you are on medicines used to thin the blood like Warfarin.
Medicines used to treat certain types of cancers like methotrexate.
Medicines used to treat gout like probenecid.
If you have kidney problems and you are taking antibiotics like Tobramycin, Gentamicin and Vancomycin.

Dosage

Overdose

Your doctor or nurse will give this medicine. Therefore, it is less likely to provide you with more or less of this medicine. However, if you experience loose motions, nausea, vomiting and fits immediately after taking this medicine, inform your doctor as soon as possible.

Missed a Dose

You will be monitored by your doctor or nurse on when the medicine should be given to you. It is unlikely that you will be missing any dose. However, if you think your doctor or nurse might have missed a dose, inform them. It is advisable not to miss any dose of antibiotics as it can result in the failure of the therapy.

Frequently Asked Questions (FAQs)

No, this medicine is used for treating severe infections caused by bacteria and not viral infections. This medicine should only be taken when prescribed by the doctor.

This medicine contains sodium, so it is advisable to be cautious and discuss your dietary restrictions with your doctor before taking it.

Piperacillin+Tazobactam should not be taken by individuals who are allergic to it or to other antibiotics such as Cephalosporins, Monobactam and Carbapenem. Tell your doctor if you have kidney or liver problems.

You may experience nausea, vomiting, indigestion, headache, and pain, redness and swelling at the site of injection.

The composition of Piperacillin+Tazobactam includes piperacillin and tazobactam as the active ingredients that belong to an antibiotic class of medicines.

No, you must complete the course of treatment as prescribed by the doctor. Abruptly stopping the treatment with antibiotics in midway may lead to recurring infections.

No, you should not take any medicine or self-inject any medication to treat or prevent COVID-19 without consulting a doctor. If you have been tested positive with COVID-19 immediately inform your doctor. Moreover, this medicine will be given in a hospital by your doctor or nurse as an injection. Do not self-inject this medicine.

Piperacillin+Tazobactam is indicated for the treatment of serious and complicated infections caused by bacteria such as stomach and abdominal infection, skin and soft tissue infections, diabetic foot infections due to diabetes and pneumonia. It is to be used only when an infection cannot be controlled by other antibiotics.