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Indapamide+Amlodipine

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Molecule Summary

Uses
High blood pressure
Therapy
Anti-Hypertensive
Side Effects
Dizziness, stomach upset, swelling, headache
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Molecule Description

Indapamide+Amlodipine is used to treat hypertension (high blood pressure). It combines two medications, amlodipine and indapamide. It is recommended that Indapamide+Amlodipine be taken with food, preferably in the morning, to reduce the frequency of nocturnal urination. Continue taking this medication for as long as advised by your doctor. Even if you feel well, do not stop taking it on your own, as high blood pressure often has no symptoms. Stopping the medication abruptly could worsen your condition.

Uses

Indapamide+Amlodipine is used to treat high blood pressure.

Contraindications

When should one not use Indapamide+Amlodipine

  • If you are allergic to amlodipine, indapamide or any other ingredients of this medicine
  • If you have very low blood pressure or heart-related conditions such as stenosis, cardiogenic shock, heart failure after a heart attack.
  • If you have an existing kidney failure or liver failure.
  • If you have low levels of potassium in your body.

Side effects

Common side effects of this drug are:

  • Headache
  • Dizziness
  • Sleepiness especially at beginning of treatment
  • Ankle swelling
  • Weakness
  • An upset stomach
  • Muscle cramps
  • Excessive urination

Precautions and Warnings

Pregnancy

Pregnancy

Indapamide+Amlodipine is generally not recommended during pregnancy. You should inform your doctor if you are planning a pregnancy.

Breast Feeding

Breast Feeding

Components of this medicine pass into the breastmilk. Indapamide+Amlodipine is not recommended during breastfeeding.

Driving

Driving

You may feel dizzy, tired or have a headache after taking this medicine, so you should be cautious while driving, especially during the initial days of the treatment.

Alcohol

Alcohol

Excessive alcohol consumption can raise blood pressure. Hence, caution is advised. Individuals with high blood pressure should avoid binge drinking.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have any underlying health condition related to the liver and kidneys.
  • You have heart-related conditions or recently had a heart attack or heart failure.
  • You are elderly, caution is advised while changing the dose for the elderly.
  • You have gout or diabetes.
  • You are supposed to do a test to check the parathyroid function.
  • You have fluid imbalance or imbalance of sodium or potassium levels in your body.

Mode of Action

How Does It Work?

  • Indapamide+Amlodipine contains Amlodipine, a calcium channel blocker that relaxes and widens blood vessels, improving blood flow and reducing resistance for the heart.
  • Indapamide is a diuretic that helps the kidneys remove excess salt and water, lowering blood volume and pressure on arterial walls. Together, they effectively control blood pressure and reduce the risk of complications such as strokes or heart attacks.

Interactions

Interactions with other medicines

  • Some medicines can affect the way Indapamide+Amlodipine works or Indapamide+Amlodipine itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements or herbals you are currently taking or might take to avoid any possible interactions.
  • Especially, if you are taking medicines such as antibiotics, antifungals, other anti-hypertensive medicines, cholesterol-lowering medicines, medicines for heart conditions and muscle relaxants etc.
  • Other medicines that should be used with caution are immunosuppressants, anti-HIV medicines etc.

Interactions with food items

Grapefruit juice and grapefruit should not be consumed along with Indapamide+Amlodipine, as these can cause a drop in your blood pressure.

Dosage

Overdose

Symptoms of an overdose of this medicine include dizziness, lightheadedness, weakness, fast heartbeat or excessive drop in blood pressure etc. Seek immediate medical help in case of an overdose of this medicine.

Missed a Dose

If you have missed taking any dose, take it as soon as you remember if there is sufficient time left for the next scheduled dose. If it is time for the next dose, then skip the missed dose and resume your usual dosing schedule. Do not compensate for the missed dose by taking an extra dose. Missing a dose of this medicine can lead to a rise in blood pressure and should be avoided.

Frequently Asked Questions (FAQs)

No, do not stop taking this medicine suddenly. Instead, you should consult your doctor and he/she may adjust your dose as per your needs. Follow up with your doctor regularly.

You should take your medicine regularly at the same time. In addition to that, making lifestyle changes will also help to control your blood pressure. These changes include eating a healthy diet, low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes every day and reducing alcohol consumption and stopping smoking.

Uncontrolled high blood pressure is known to cause serious complications in several body parts. High blood pressure and heart failure are critical health conditions, if not treated, can affect other organs such as the brain, kidneys and blood vessels.

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