Janumet 50/500mg Tablet
15 Tablet(s) in Strip
Product Summary
Janumet 50/500 mg Tablet contains sitagliptin 50 mg and metformin hydrochloride 500 mg, an oral antidiabetic combination used to treat high blood sugar in type 2 diabetes. Sitagliptin increases insulin production, while metformin reduces sugar production and improves the body's response to insulin; Abbott Healthcare manufactures this medicine.
Medically Reviewed by Dr. Ritu Budania
Last updated on: 13 October 2026 | 10:17 AM (IST)
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Dose Form
TABLET
Expiry
General Information
| Therapy | Anti-diabetic |
| Composition | Metformin Hydrochloride(500.0 Mg)+Sitagliptin(50.0 Mg) Metformin Hydrochloride 500.0 Mg+Sitagliptin 50.0 Mg |
Metformin Hydrochloride 500.0 Mg+Sitagliptin 50.0 Mg
℞Healing Pharma India Pvt Ltd
₹288 ₹253.44
₹16.9/Tablet
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*Offer applicable on orders above ₹1000About Janumet
Janumet 50/500mg Tablet is used alongside diet and exercise to control blood sugar in adults with type 2 diabetes when a single medicine is not enough. It contains sitagliptin and metformin, which lower glucose through two separate mechanisms.
Metformin reduces the glucose the liver releases and improves how well muscle responds to insulin. Sitagliptin blocks the enzyme DPP-4, protecting the gut hormones that prompt the pancreas to release insulin after a meal and reduce glucagon, so insulin is released only when glucose is actually rising.
Take it twice daily with or immediately after food, which substantially reduces the nausea, metallic taste and loose stools metformin can cause. Do not stop when your readings improve; that improvement is the treatment working.
Seek urgent medical attention for severe persistent upper abdominal pain spreading to the back, which may indicate pancreatitis, or for unusual muscle pain, rapid breathing and extreme tiredness, which may indicate the rare complication lactic acidosis.
Kidney function must be checked before starting and at least yearly, and the medicine stopped before contrast scans and surgery. Long-term metformin lowers vitamin B12, so levels should be monitored periodically.
Istamet 50/500mg tablet, Sitazor 50/500mg tablet and Glura M 500mg tablet are a few more tablets that also contain sitagliptin and metformin.
Uses
Contraindications
- If you are allergic to sitagliptin, metformin or any other ingredients of Janumet tablet.
- If you have severe kidney or liver disease.
- If your diabetes is not under control and you also have high blood sugar, nausea, vomiting, loose motions, rapid loss of weight, pain in the stomach, breathing difficulty, sleepiness, etc.
- If you have dehydration or you have the presence of severe infection.
- If you have to go to do an x-ray or scan dye is injected in your blood before doing the x-ray or scan.
- If you have a recent history of a heart attack.
- If you are a heavy alcohol drinker.
- If you are a lactating mother.
Side effects
- Nausea
- Vomiting
- Stomach pain
- Diarrhoea
- Constipation
- Flatulence (gas)
- Low blood sugar
Precautions and Warnings
Alcohol
WITH CAUTIONAvoid consuming alcohol with Janumet 50 mg/500 mg tablet as it may lead to 'lactic acidosis'. This may cause symptoms such as vomiting, stomach pain, fatigue, breathing difficulty, muscle cramps, decrease body temperature, reduced heartbeats.
Pregnancy
UNSAFE50mg/500mg tablet should not be taken while pregnant. If a patient wishes to become pregnant or if a pregnancy occurs, treatment should be stopped immediately.
Breastfeeding
UNSAFEA component of this medicine can pass through breastmilk and can cause harm to the breastfed baby if taken by lactating mother. This medicine should not be taken by lactating mother.
Driving
WITH CAUTIONThis medicine can cause dizziness or sleepiness. Avoid driving if you have dizziness or sleepiness after taking this medicine.
Other General Warnings
- You have a skin blister after taking this medicine.
- You have a fever, vomiting, loose motion, heat exposure, and less fluid intake.
- You have vomiting, pain in the stomach, breathing difficulty, tiredness, muscle cramps, decreased body temperature, and decreased heartbeat after taking this medicine.
- You have low blood sugar after taking other anti-diabetic medicines along with this medicine.
- You have type 1 diabetes mellitus.
- You are undergoing any surgery.
- Your doctor tells you that you have increased triglyceride levels in your blood and you have gallstones.
Directions for use
- Janumet tablet should be taken as directed by your doctor.
- Swallow it as a whole with a glass of water, do not cut, break or chew the medicine.
- It should be taken with meals.
- For optimal results, it would be best to take it at a fixed time and not consume it more than that prescribed by your doctor.
- Do not stop taking Janumet 50mg/500mg tablet on your own without informing your doctor.
Storage and disposal
- Store Janumet tablets at a temperature not above 30°C in a cool and dry place.
- Keep it out of the reach of children and pets.
Quick tips
- Along with taking Janumet tablet, it is essential that you do certain lifestyle modifications like exercising for 30 minutes daily, maintaining a healthy weight, managing stress, avoiding smoking, and drinking alcohol.
- It is also advised to have a balanced diet with adequate fruits and vegetables to control blood sugar levels effectively.
- Regularly monitor your blood sugar levels as directed by your doctor and report any changes.
- It is essential to take this tablet at the same time every day and not to skip doses. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.
- Some individuals may experience headache, stomach pain, diarrhoea, and nausea/vomiting after taking the Janumet 50/500mg tablet. Inform your doctor if these effects bother you or do not go away.
- Talk to your doctor if you have kidney or liver disease.
- Take Janumet with your meals for better digestion. Do not cut or break the tablets; swallow them whole. If you have trouble, talk to your doctor.
Dosage
Overdose
Missed a dose
How Janumet works
Interactions
Interactions with other medicines
- Some medicines can affect how Janumet tablet works, or this medicine itself can reduce the effectiveness of other medicines simultaneously.
- Tell your doctor about all the medicines, supplements, or herbs you are taking to avoid any possible interaction.
- Especially if you are taking other antidiabetic medicines.
Food interactions
Frequently asked questions
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Substitutes for Janumet
References
- Janumet 50 mg/1000 mg film-coated tablets - Summary of Product Characteristics (SmPC) (emc). Merck Sharp & Dohme. Accessed 31 Jul 2026.
- Janumet 50 mg/1000 mg film-coated tablets - Patient Information Leaflet (PIL) (emc). Merck Sharp & Dohme. Accessed 31 Jul 2026.
- JANUMET (sitagliptin and metformin hydrochloride) tablet - Prescribing Information (USPI). DailyMed, U.S. National Library of Medicine. Accessed 31 Jul 2026.
- Sitagliptin - MedlinePlus Drug Information. U.S. National Library of Medicine. Accessed 31 Jul 2026.
- Metformin - MedlinePlus Drug Information. U.S. National Library of Medicine. Accessed 31 Jul 2026.
- Standards of Care in Diabetes. American Diabetes Association (ADA). Accessed 31 Jul 2026.
- WHO Model List of Essential Medicines. World Health Organization. Accessed 31 Jul 2026.
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