Zivast L Tablet

• It is used to treat hypertension (high blood pressure) when it exists with increased/ deranged cholesterol

• If you have any allergic reaction to this medicine or any of the ingredient of this medicine
• If you have or ever had any liver disease, any abnormality in liver function test
• If you are being treated with medicines for hepatitis C like Glecaprevir/Pibrentasvir
• If you are pregnant
• If you have blockage of any duct that carries bile from the liver to gallbladder (obstructive biliary disorders)
• If you have diabetes or kidney disorder and you have been treated with Aliskiren (a medicine used to treat high blood pressure)

• Headache
• Nausea
• Diarrhoea
• Body pain (joint, back, throat, muscle)
• Swelling of nasal passages and bleeding from the nose
• Abnormal liver function test and increased creatinine level
• Dizziness
• Vertigo or giddiness
• Increased potassium in the blood
• Anaemia
• A sudden drop in blood sugar level
• Weakness

Other General Warnings

• If you have liver or kidney disease or have had a kidney transplant
• If you experienced any muscle problems after taking other cholesterol-lowering medicines
• If you are taking medicine for bacterial infection like fusidic acid, as it may cause serious muscle injury
• If you have breathing difficulty
• If you are addicted to alcohol
• If you have any thyroid problems
• If you ever had an allergic reaction like swelling of the face, lips, throat and tongue
• If you have vomiting or diarrhoea, dehydration can result in low blood pressure and can be dangerous, have an adequate amount of water and fluids
• If you have narrowing or blockage of the blood vessels of one or both kidneys
• If you are taking medicines like Diuretics
• If you are suffering from any heart disease
• Caution is required if you are a diabetic and taking medicines like Enalapril, Lisinopril and Ramipril

• Take Zivast L Tablet as directed by your doctor
• Always take it at the same time every day
• Do not change your dose unless your doctor tells you to
• Never stop this medicine on your own

• Do not store above 25°C
• Store it in the original packaging to protect it from sunlight and moisture
• Keep out of sight and reach of children

Overdose

Missed a Dose

How Does It Work?

• Cholesterol is made by an enzyme HMG-CoA reductase. Atorvastatin inhibits this enzyme, lowers bad cholesterol levels (LDL levels), triglyceride levels and also other lipids or fats in the blood. It also increases the good cholesterol known as high-density lipoprotein (HDL) levels
• Angiotensin-II released in your body causes the blood vessels to narrow which leads to an increase in blood pressure. Losartan prevents the binding of Angiotensin-II to its receptors, causes the blood vessels to relax and lowers the blood pressure

Interactions with other medicines

• This medicine contains Atorvastatin and Losartan, any interactions seen with these two components when taken alone may occur with this combination
• There can be a drastic drop in blood pressure if taken with other medicines like Amlodipine, Digoxin, Ramipril, Lisinopril or Aliskiren, this can be dangerous and should be avoided
• Avoid excess use of pain killers like Phenazone or Indomethacin as this can damage kidneys
• Medicines used to treat HIV/AIDS like Ritonavir, to treat hepatitis C like Telaprevir, antibiotics or any antifungal medicines like Erythromycin or Ketoconazole
• Blood thinners like Warfarin
• Antacids like Cimetidine and Magnesium
• Avoid using along with other medicines for cholesterol like Ezetimibe
• Avoid taking potassium supplements as Losartan is known to increase potassium levels
• Medicines which are known to increase potassium levels like Diuretics (Amiloride, Triamterene and Spironolactone)
• Medicines which increase the serum potassium like Heparin and Trimethoprim-containing medicines should be avoided
• It can increase side effects caused by Lithium
• Medicines used to treat specific cancer like Amifostine
• Medicine used to treat muscle spasm like Baclofen

Interactions with food items

• Intake of grapefruit juice should be in a limited quantity as grapefruit may alter the effect of Atorvastatin
• It is advised to avoid high potassium-containing foods as Losartan is known to increase potassium levels