Pendicard Trio 4/1.25/5Mg Strip Of 10 Tablets

• If you are allergic to perindopril or any other ACE inhibitor, to indapamide or other sulfonamide-derived medicines, to amlodipine or other dihydropyridine calcium channel blockers, or to any of the other ingredients.
• If you have ever had angioedema, a sudden swelling of the face, lips, tongue or throat it was caused by a medicine.
• If you are pregnant or breastfeeding.
• If you have severe kidney impairment, narrowing of the arteries to both kidneys, or are on dialysis.
• If you have severe liver impairment or hepatic encephalopathy.
• If you have a low blood potassium level.
• If you have a narrowed aortic valve or an obstruction to blood leaving the heart, or cardiogenic shock.
• If you are taking a medicine containing aliskiren, or an angiotensin receptor blocker alongside this medicine when you have diabetes or kidney disease.

• Dry cough
• Dizziness
• Headache
• Ankle swelling
• Flushing
• Tiredness
• Muscle cramps
• Nausea
• Palpitations
• Low blood potassium
• Raised uric acid

Other General Warnings

• You have diabetes, heart failure, liver disease or kidney disease.
• You have a fever, sore throat, abdominal pain, nausea or vomiting after taking this medicine.
• You have swelling of the face, tongue etc after taking this medicine.
• You have a sun allergy after taking this medicine.
• Your blood pressure decreases less than normal after taking this medicine.

• Take Pendicard Trio 4/1.25/5Mg tablet as directed by your doctor.
• Swallow the tablet whole with a glass of water and do not crush or chew it.
• Take it in the morning and before a meal, as this suits the diuretic component.
• Take it at the same time each day, and keep taking it even when you feel well.
• Do not stop or change the amount on your own, as your blood pressure will rise again.
• Stand up slowly for the first few days, as you may feel dizzy.

• Store Pendicard Trio 4/1.25/5Mg tablet in a cool and dry place, protected from direct sunlight, moisture and heat.
• Keep it in the original packaging until you take it.
• Keep the medicine out of the reach of children and pets.
• Do not use it after the expiry date or if it looks damaged.
• Do not flush unused medicine down the toilet or throw it into a drain. Return it to a pharmacy for safe disposal.

• Take Pendicard Trio 4/1.25/5Mg tablet in the morning before food, and keep taking it even when you feel well.
• A dry, tickly cough that does not settle is a known effect of the perindopril component. Tell your doctor rather than stopping the medicine yourself.
• Report swelling of the face, lips, tongue or throat, or difficulty breathing or swallowing, as an emergency.
• Stand up slowly, especially in the first few days of treatment.
• Tell your doctor immediately if you become pregnant or are planning to, as this medicine must not be used in pregnancy.
• Keep your blood pressure, kidney function, potassium and sodium checks as arranged.
• Contact your doctor if you have vomiting, diarrhoea or heavy sweating, as dehydration affects your kidneys and blood salts.
• Avoid grapefruit, and avoid potassium-containing salt substitutes unless your doctor approves.

Overdose

Missed a Dose

Interactions with other medicines

• Tell your doctor about all the medicines, supplements and herbal products you use before starting Pendicard Trio 4/1.25/5Mg tablet, and before any surgery or anaesthetic.
• Potassium supplements, salt substitutes containing potassium and potassium-sparing diuretics can interact unpredictably with this combination, as perindopril raises potassium while indapamide lowers it. Do not use them unless your doctor advises.
• Aliskiren, and angiotensin receptor blockers taken alongside an ACE inhibitor, increase the risk of kidney problems and abnormal potassium and must generally be avoided.
• NSAID painkillers reduce the blood-pressure-lowering effect and can worsen kidney function.
• Lithium levels rise with both perindopril and indapamide and need monitoring.
• Medicines that prolong the heart's electrical conduction, and other medicines that lower potassium such as steroids or stimulant laxatives, add to the risk of rhythm disturbance.
• Ketoconazole, itraconazole, clarithromycin, ritonavir and grapefruit juice raise amlodipine levels and may lower blood pressure excessively.
• Insulin and oral diabetes medicines may need adjusting, as indapamide can raise blood sugar while perindopril can lower it.

Interactions with food items