Neorof 1% Inj 10ml
By NEON LABORATORIES LIMITED
10ml Infusion in Vial
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Neorof Injection is used to administer general anaesthesia. Its active ingredient is propofol. It is issued only by an anaesthetist at the time of major surgeries to render the patient unconscious and safely carry out any surgical procedure. Neorof can also maintain the anaesthesia for a longer duration during surgery, known as maintenance. In some cases, such as when patients need additional support to breathe in the form of a ventilator or tube, a general anaesthetic agent is required to ensure the effective functioning of the device. Sometimes for minor procedures, Neorof can be used only to provide pain relief while the patient is conscious. This is an intravenous injection and is only administered by trained medical professionals....
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|Uses||Induction and maintenance of general anaesthesia, For conscious sedation for surgical and diagnostic procedures, For sedation of ventilated patients receiving intensive care.|
|Side effects||Nausea, vomiting, headache, decrease in heart, decrease in blood pressure, pain at the injection site, skin rash|
Check more medicines with composition as Propofol(1.0 %)
Uses of Neorof 1 %
- As per CDSCO,
- Induction and maintenance of general anaesthesia.
- For conscious sedation for surgical and diagnostic procedures
- For sedation of ventilated patients receiving intensive care.
Contraindications of Neorof 1 %
- If you have a known hypersensitivity to propofol or any of its components.
- If you are allergic to eggs, egg products, soybeans, or soy products.
Side effects of Neorof 1 %
- Changes in blood pressure
- Decreased Cardiac Output
- Pain at the injection site
- Skin rash
- Stopping of respiratory activity
Precautions and Warnings of Neorof 1 %
Can I take Neorof Injection during pregnancy?
Neoref injection can cross the placenta and affect the fetus, but it has been safe when used in pregnant patients under a doctor's care.
Can I take Neorof Injection while breastfeeding?
Neorof Injection is not recommended for use in nursing mothers because propofol has been reported to be excreted in human milk, and the effects of oral absorption of small amounts of propofol are not known.
Can I drive if I have taken Neorof Injection?
Neorof Injection cannot be used during driving as it is general anaesthetic and sedative medicine.
Can I consume alcohol with the Neorof Injection?
It is strongly contraindicated, as it is a general anaesthetic and sedative medicine
Other General Warnings
Talk to your doctor if
- You have any food allergies.
- You should disclose the concurrent use of any other medications.
Mode of Action of Neorof 1 %
How Does It Work?
The exact mechanism of action is poorly understood. It acts on specific chloride channels in the brain mediated by a chemical substance known as GABA. It is postulated that propofol helps bind GABA to these chloride channels for longer. Because of this, the channel remains active for a long time, and an inhibitory effect is seen....
Directions for Use of Neorof 1 %
- Shake well before use.
- Do not use if there is clumping or aggregation, if large droplets are seen, or if there are other forms of phase separation indicating that the stability of the product has been compromised.
- Slight creaming may be visible upon prolonged standing, but it should disappear on shaking.
- Neorof Injection must be prepared for use just before the start of each anaesthetic/sedative procedure.
- The vial rubber stopper should be disinfected using 70% isopropyl alcohol.
- Neorof Injection should be drawn into a sterile syringe immediately after a vial is opened.
- When withdrawing Neorof Injection from vials, a sterile vent spike should be used.
- The syringe should be labelled with details, including when the vial was opened.
- The administration should commence promptly and be completed within 12 hours after the vial has been opened.
Interactions of Neorof 1 %
Interactions with other medicines
- Other medications that affect blood pressure or heart rhythm
- Medications that cause slowing down respiratory rate, such as opioids.
Interactions with food items
- The patient must be fasting for 12 hours before surgery for general anaesthesia or as advised by the physician for individual procedures.
Storage and disposal of Neorof 1 %
Store it between 4° to 25°C (40° to 77°F). Do not freeze. Shake well before use. Keep in a dry and cool place.
Dosage of Neorof 1 %
If an overdose occurs, Neorof Injection administration should be discontinued immediately. Overdose symptoms include cardiorespiratory depression, i.e., decreased blood pressure, difficulty breathing or a dramatic rise in body temperature, flushed skin, sweating, or a rapid increase in heart rate. In rare cases, if the injection is given for too long, it can cause fatal toxicity. Appropriate management by the anaesthetist is advisable....
Missed a Dose
The injection should only be administered at the discretion of an anaesthetist for use during or prior to a procedure. Incorrect maintenance may cause the patient to regain consciousness.
Frequently Asked Questions (FAQs)
Q: How long will I remain drowsy if given Neorof injection?
A: The exact duration of anaesthesia varies from patient to patient and depends upon the duration of the procedure and the dose of the agent administered.
Q: Is this injection commonly used during gall bladder surgery? Is it safe?
A: Neoref injection can be used in different ways for many major surgical procedures. It should only be administered by a trained anaesthetist.
Q: My father is admitted to the ICU, and my doctor has prescribed this injection as he could not breathe himself. Is this risky?
A: Patients who cannot breathe well may require the support of a ventilator. At this time, agents such as Neoref are used to sedate the patient to ensure the machine works well. The procedure is only done under the care of an anaesthetist or ICU specialist doctor.
- DIPRIVAN®(propofol) injectable emulsion, USP
- Clinical Pharmacokinetics and Pharmacodynamics of Propofol,Marko M. Sahinovic, Michel M. R. F. Struys, and Anthony R. Absalom
- Folino TB, Muco E, Safadi AO, et al. Propofol. [Updated 2021 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:
- [Internet]. 2022 [cited 24 February 2022]. Available from:
Expires on or After
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