Esoz D 40 Capsule

• If you are allergic to esomeprazole, domperidone or other ingredients of Esoz D 40 capsule.
• If you have a blockage or tear in the intestines.
• If you suffer from liver or kidney disorder.
• If you suffer from bleeding in the digestive system.
• If you suffer from a tumour of the pituitary gland (Prolactin pituitary tumours).
• If you suffer from heart problems like congestive heart failure, heart rhythm problems, electrolyte imbalance.
• If you are using a medicine that might affect the contraction of the heart muscle (QT prolongation).
• If you are using medicines like Nelfinavir (used in HIV infection), Clarithromycin (antibiotic), Ketoconazole (antifungal) or Verapamil (used in high blood pressure and chest pain).

• Headache
• Nausea
• Vomiting
• Stomach pain
• Diarrhoea
• Constipation

Other General Warnings

• You have liver and kidney-related diseases.
• You have a specific blood test (Chromogranin A).
• You develop black stools or have a stomach tumour.
• You experience fractures or have osteoporosis or taking steroids.
• You develop skin lesions, especially in the sun-exposed area after taking the medicine.
• You are using medicines to treat HIV or apomorphine (used to treat muscle stiffness).
• You have heart problems and symptoms like palpitations, difficulty in breathing and unconsciousness.
• You experience stomach pain or indigestion, unexplained weight loss, have problems while swallowing, vomit out food or blood after taking the medicine.
• You experience low levels of vitamin B12. The medicine reduces the absorption of vitamin B12 after long term use. Supplements may be needed.
• You are using capsules for long-term treatment (more than three months), the blood magnesium levels may decrease. The doctor may perform regular tests for the same.
• It is recommended for patients below the age of 18 years.
• Taking the medicine for more than one year may increase the chances of developing bone fractures.
• The medicine leads to a slightly increased risk of bacterial infections due to Salmonella and Campylobacter.

Overdose

Missed a Dose

How Does It Work?

• A pump called the proton pump in the stomach is responsible for the flow of stomach acids.
• Esomeprazole binds to the proton pump in stomach cells and blocks the acid secretion.
• Domperidone increases the motility of the stomach and intestines so that acid does not reflux back into the food pipe.

Interactions with other medicines

• Some medicines affect the way the Esoz D 40 capsule works or the medicine itself reduces the effectiveness of other medicines taken at the same time.
• Inform the doctor regarding the medicines, supplements or herbals you take or might take to avoid possible interaction.
• The medicine must not be taken concomitantly along with medicines like Nelfinavir (used to treat HIV infection), Amiodarone (used to treat muscle stiffness), Clarithromycin (antibiotic), Ketoconazole (antifungal) or Verapamil (used in high blood pressure, chest pain).
• The capsule must also not be taken along with medicines used to treat heart problems (Quinidine, Sotalol), psychiatric illness (Haloperidol, Citalopram), antifungals (Pentamidine), antimalarials (Halofantrine, Lumefantrine), medicines used to treat allergies (Mizolastine), medicines to treat in cancer (Toremifene, Vandetanib), gastric emptying medicines (Cisapride) and other medicines like Diphemanil and Methadone.
• Concomitant use of the capsule with medicines used to treat psychiatric illness (Diazepam), used to treat fits (Phenytoin) is not recommended as it may increase the side effects of the medicines.
• Medicine used to treat heart failure like Digoxin may lead to toxicity when taken with the medicine.
• If you are using Warfarin (blood-thinner) along with the medicine, caution is needed as there are chances of increased bleeding.
• Other medicines like Rifampicin, Methotrexate, Tacrolimus, Voriconazole, Cilostazol, Clopidogrel, Azithromycin, St John's wort, etc must be used cautiously along with Esoz D 40 capsule.

Interactions with food items