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Dolosafe Tablet

10 Tablet(s) in Strip
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Dolosafe Tablet Description

Dolosafe tablet is a prescription painkiller. This medicine is prescribed for use in people with moderate to severe pain. Pain is an uncomfortable feeling mediated by chemical substances in the body.

It occurs in response to an injury, tissue damage, or disease. There can be many types of pain. Their location and type decide the painkiller to be used. The active ingredients in Dolosafe tablets are Tramadol and Paracetamol. Tramadol is an opioid analgesic that binds to the opioid receptors in the body to help control pain. It also increases the levels of certain chemical mediators such as serotonin and norepinephrine that help to reduce the pain sensation. Paracetamol is used to control pain and reduce fever due to its action on prostaglandins. Its role in pain control is due to its action in the central nervous system (CNS) to promote the synthesis of serotonin. Directions for use of Dolosafe tablets should be strictly followed. It should be taken in the dose and for the duration prescribed. Dolosafe tablets are habit-forming. In case of any side effects, it is recommended to consult a medical professional. Some common side effects of Dolosafe pills include nausea, vomiting, increased sweating, drowsiness, and liver damage.


Product Summary

Offer Price₹36.93
You Save₹6.52 (15% on MRP)
ContainsTramadol(37.5 Mg) + Paracetamol / Acetaminophen(325.0 Mg)
UsesManagement of acute moderate to severe pain
Side effectsNausea, Vomiting, Dizziness, Sleepiness, Liver damage
Check more medicines with composition as Tramadol(37.5 Mg) + Paracetamol / Acetaminophen(325.0 Mg)

Uses of Dolosafe Tablet

  • As per CDSCO, Dolosafe tablet is used to manage acute moderate to severe pain (for five days or less).

Contraindications of Dolosafe Tablet

  • Do not use Dolosafe tablets, or use caution:
  • If you have a known hypersensitivity to tramadol, paracetamol, or any other ingredients of Dolosafe tablets.
  • If you have severe bronchial asthma.
  • If you have a known or suspected gastrointestinal obstruction (a condition causing a blockage in the intestines), including paralytic ileus (a condition that affects the contraction of gut muscles).
  • If you suffer from uncontrolled seizures (not on treatment).
  • If you have an alcohol/drug dependence disorder.
  • If you have increased intracranial pressure (increased pressure in the fluid in the spine and brain), brain tumours, or head injury.
  • If you are under 12. It should not be used to manage post-operative pain in children under the age of 18 following tonsillectomy and adenoidectomy.

Side effects of Dolosafe Tablet

  • Side effects of Dolosafe tablets include:
  • Nausea
  • Vomiting
  • Increased sweating
  • Drowsiness
  • Liver damage

Precautions and Warnings of Dolosafe Tablet



Can I take Dolosafe tablets during pregnancy?
It is not advisable to use Dolosafe tablets in pregnancy. Its use on pregnant women has not been studied adequately. Inform your doctor if you are pregnant or planning to conceive.

Breast Feeding

Can I take Dolosafe tablets while breastfeeding?
The use of Dolosafe tablets in breastfeeding has not been studied adequately and hence is not advisable. It has been found to cause excessive drowsiness and a slowed breathing rate in the breastfed infant. If you take this medicine while breastfeeding, look out for these symptoms in your child. Inform your doctor before you take this medicine.


Is it ok to drive if I have taken a Dolosafe tablet?
Driving is not recommended after taking a Dolosafe tablet. This medicine may cause dizziness and drowsiness, so it is recommended that users do not drive or operate heavy machinery if they experience any of these side effects.


Can I consume alcohol with Dolosafe tablets?
Alcohol consumption while on Dolosafe tablets is contraindicated. It can increase the depressant action in the central nervous system (CNS) and cause respiratory depression.

Other General Warnings

Talk to your doctor if
  • You are diagnosed with glaucoma.
  • You have seizures.
  • You have heart disease.
  • You have liver or kidney disease.
  • You are on any other medications along with this tablet.
  • You experience mood changes or sudden negative thoughts.

Mode of Action of Dolosafe Tablet

How Does It Work?

Dolosafe contains a combination of two ingredients: Tramadol and Paracetamol. Tramadol is an opioid analgesic. This means that it binds to the opioid receptors in the body to help control pain. Thi...
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Directions for Use of Dolosafe Tablet

  • Take Dolosafe tablets precisely as advised by the doctor.
  • Do not take an extra dose even if you cannot notice the effects of this medicine.
  • Swallow Dolosafe tablets as a whole with a glass of water.
  • Do not break or chew this tablet.
  • Take this medicine with or without food.

Interactions of Dolosafe Tablet

Interactions with other medicines

  • Dolosafe tablets can interact with certain medicines and cause adverse side effects. It is advised to inform the doctor of all current medication to be checked for possible interaction issues.
  • Dolosafe tablets should not be prescribed with selegiline, rasagiline, or other monoamine oxidase inhibitors (MAOIs). It is contraindicated as the risk or severity of adverse effects may increase. If ...
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  • Dolosafe tablets should not be given with antidepressants, as tramadol may increase the pill's central nervous system (CNS) depressant effects. The increase in serotonin levels can precipitate a dange...
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  • Dolosafe tablets should not be prescribed with blood thinners like aspirin, heparin, or warfarin. It can increase the chances of bleeding.
  • Co-administration with medications such as pentazocine, nalbuphine, and butorphanol is not recommended with tramadol, as they may reduce the analgesic effects of Dolosafe tablets.

Storage and disposal of Dolosafe Tablet

Store Dolosafe tablets at room temperature, away from wet surfaces, direct sunlight, and humidity. Keep away from children and pets. Check the expiration date before taking the tablets. Dispose of the...
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Dosage of Dolosafe Tablet


Dolosafe tablet overdose can slow down the breathing rate, cause excessive sleepiness or coma, constricted pupils, and excessive sweating. Sometimes bradycardia (decreased heart rate), hypotension (re...
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Missed a Dose

If you have missed a dose of the Dolosafe tablet, try to take it as soon as you remember. If you recall the missed dose when it is almost time for the next one, skip the missed one and continue with y...
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Content Details


Dr. Bhavika Shah

MBBS, MD (Dermatology), DNB (Dermatology)

Frequently Asked Questions (FAQs)


Q: How long do the effects of Dolosafe tablets last?

A: The amount of time Dolosafe effects last varies on how long you have been taking Dolosafe. Usually, they last about 1-2 days.

Q: I took one Dolosafe tablet. Yet, I am feeling very sleepy and dizzy. Should I take my next dose?

A: Dolosafe is known to cause excessive sleepiness, drowsiness, and dizziness. These are normal side effects. However, if you feel incapacitated or uncomfortable, consult your doctor for a change in dose or an alternate medication.

Q: I took Dolosafe for 2 days, but my pain is still present. Should I take another dose?

A: Dolosafe must be taken for the entire course as prescribed by your doctor. Do not increase the dose without the prescription of your treating physician.
Product Details
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Last Updated on: 11 Apr 2022 | 08:58 AM (IST)
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