Combigan Eye Drops

• If you are allergic to Timolol, Brimonidine or any other component of Combigan Ophthalmic solution.
• If you have a history of bronchial asthma or severe chronic obstructive pulmonary disease (COPD).
• If you have any heart disease or disorder including heart failure.
• If you have any psychiatric disease and are on medicine such as rasagiline, selegiline, isocarboxazid, phenelzine, amitriptyline, nortriptyline, desipramine and mianserin.

• Burning sensation
• Pain, discharge, dryness, irritation, blurred vision, redness of the eye
• Low mood
• Sleepiness, headache
• Hypertension
• Dry mouth
• Swelling and itching of the eyelid

Other General Warnings

• You experience an allergic reaction.
• You have heart, respiratory, diabetes and hyperthyroid (overactive thyroid) disease or condition.
• You experience loss of vision or dryness of the eye.
• You have a planned surgery.
• You wear contact lenses.
• Combigan Ophthalmic solution should not be used in children below 2-years of age.

• Use this medicine as instructed by your doctor.
• Follow directions carefully & do not miss an application.
• Wash your hands thoroughly before and after applying.
• Close your eyes for 2 - 3 minutes and do not blink or squeeze.
• Avoid touching your eyes with the dropper. Keep the dropper clean.
• Wipe any excess liquid from your face with a tissue.
• Use the exact number of drops recommended.

• Store it at a temperature not exceeding 15°C - 25°C.
• Protect it from freezing.
• Keep it out of the reach of children and pets.
• Discard the solution if it changes colour, turns cloudy or if it contains particles.

• Combigan Eye drops are used to treat glaucoma and lower the pressure within the eye which is ocular hypertension.
• Wash your hands thoroughly before using the eye drop to avoid introducing any bacteria into your eye.
• Please consult your doctor if you have any other eye conditions before using Combigan Eye Drop.
• This medication should be taken as long as the doctor has prescribed it to you. The doctor normally adjusts the dose and duration of this medicine depending on the medical condition.
• Inform your doctor if you are pregnant, planning on becoming pregnant, or breastfeeding before taking this eye drop.
• Dry mouth, sleepiness, headache, swelling and itching of the eyelid may occur in some individuals with the use of this Combigan Eye drop. Inform your doctor if these effects bother you or do not go away.
• You should avoid driving or operating heavy machinery if you experience blurred vision after using Combigan Eye drop.
• If you use any other eye drop product in addition to this one, wait at least 15 minutes between applying both medications.
• It should not be used in children below 2 years of age.

Overdose

• As Combigan Ophthalmic solution is meant for external application, cases of overdose are unlikely. However, upon accidental ingestion, contact your doctor immediately or visit the nearest hospital.
• If you have applied extra quantities of it, wipe out the excess of the medicine with tissue or cotton.

Missed a Dose

How Does It Work?

• Combigan Ophthalmic solution contains Timolol and Brimonidine. They work by decreasing the raised intraocular (inside the eye).
• Brimonidine has the dual action of reducing the aqueous humour fluid (fluid in the front part of the eye) production and increasing the outflow of aqueous fluid.
• Timolol acts by decreasing the aqueous humour production, lowering the build fluid pressure within your eye.

Interactions with other medicines

• Since Combigan Ophthalmic solution is to be used externally, it is less likely to interact with other medicines. However, consult your doctor if you are taking other medicines for treating other health conditions.
• The effect of Combigan Ophthalmic solution may be increased with medicine used to calm the central nervous system such as morphine, zolpidem and lidocaine.
• The effect of Combigan Ophthalmic solution may be increased with medicine such as diltiazem, verapamil, propranolol, atenolol, amiodarone, digitalis, and guanethidine used for heart conditions.
• Concomitant use of Combigan Ophthalmic solution with medicine used to increase heart rate such as adrenaline may cause dilation of the pupil (mydriasis).
• Combigan Ophthalmic solution may increase the effect of blood sugar-lowering medicine such as metformin, and insulin and may hide the symptoms of lower blood sugar.
• Concomitant use of Combigan Ophthalmic solution with iodine contrast medium or intravenous lidocaine should be avoided.