Amize Tablets
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10 Tablet(s) in Strip
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Amize Tablets Description
Amize tablet is a prescription medicine mainly used to treat moderate to severe depression. Depression is a type of mood disorder characterised by an episode of sadness, mood swings, loss of interest
, hopelessness, etc. Amize tablet is a combination of two components: Amitriptyline and Chlordiazepoxide. Amitriptyline is an antidepressant that works by increasing the levels of chemical messengers in the brain, which helps regulate mood and also treats depression. Chlordiazepoxide increases the inhibitory effects of a neurotransmitter called GABA (gamma-aminobutyric acid) and produces sedating and calming effects. Amize tablets should be taken only after consulting a doctor. Many side effects are associated with this medicine, so the dosage must be carefully monitored. Complete the entire course of treatment and do not stop taking this medicine suddenly without consulting the doctor, as it can cause clinical worsening of your condition or may lead to withdrawal-like symptoms.
Product Summary
| Offer Price | ₹37.84 |
| You Save | ₹6.16 (14% on MRP) |
| Contains | Amitriptyline |
| Uses | Moderate to severe depression associated with anxiety |
| Side effects | Drowsiness, Dry mouth, Nasal congestion, Blurred vision, Constipation, Weight gain, Sexual dysfunction |
| Therapy | ANTI-DEPRESSANT |
Check more medicines with composition as Amitriptyline
Uses of Amize Tablets
- As per CDSCO and USFDA, the Amize tablet is used for the following:
- Treatment of moderate to severe depression
Contraindications of Amize Tablets
- It is contraindicated in the following cases:
- If you are allergic to any components of Amize tablet, i.e. Amitriptyline or Chlordiazepoxide
- If you are taking medicines like Monoamine Oxidase Inhibitors (MAOIs) and antipsychotic medications or using other anti-anxiety or sedative medicines
- If you have glaucoma (increases the fluid pressure in the eyes)
- If you recently had a heart condition like a heart attack or myocardial infarction
- If you have a history of seizure or epilepsy
- If you have liver or kidney disease
- If you have respiratory issues like asthma or sleep apnea
- If you are a pregnant or breastfeeding mother
Side effects of Amize Tablets
- Side effects of Amize tablets include the following:
- Drowsiness
- Dry mouth
- Nasal congestion
- Blurred vision
- Constipation
- Weight gain
- Sexual dysfunction
Precautions and Warnings of Amize Tablets
Pregnancy
Q:
Can I take an Amize tablet during pregnancy?
A:
Amize tablets are unsafe during pregnancy. Some research data have shown a definite risk to unborn babies and mothers. Your doctor may prescribe Amize tablet only during life-threatening conditions if they think the benefits outweigh the risks. Do not take this medicine without consulting your doctor.
Breast Feeding
Q:
Can I take an Amize tablet while breastfeeding?
A:
Amize tablets are not recommended during breastfeeding. It gets excreted into breast milk and can harm the baby. Your doctor may advise you to stop breastfeeding for a while or prescribe low doses if you continue breastfeeding. Discuss the potential risks and benefits of taking an Amize tablet with your doctor.
Driving
Q:
Can I drive if I have taken an Amize tablet?
A:
Amize tablets may cause side effects that could affect your ability to drive. It may decrease your alertness, affect your vision and cause dizziness, lethargy, lightheadedness. You should avoid driving if you experience these side effects after taking this tablet.
Alcohol
Q:
Can I consume alcohol with the Amize tablet?
A:
Alcohol consumption with Amize tablet is not advised. This may lead to increase side effects of the medicine and result in severe dizziness, fatigue, stomach pain, nausea, lethargy, etc.
Other General Warnings
Talk to your doctor if
- You have any allergic reactions after taking the Amize tablet.
- You notice any suicidal ideation or self-harming thoughts.
- You experience sudden or severe changes in thought, behaviour or mood.
- You notice serotonin syndrome-like symptoms.
- You are pregnant or planning for it.
- You are over 65 years; the dose of this medicine should be carefully monitored to prevent serious side effects.
- You are using any ayurvedic/herbal medicines, vitamins and other health supplements.
Mode of Action of Amize Tablets
How Does It Work?
Amize tablet is a combination medicine that contains Amitriptyline (12.5mg) and Chlordiazepoxide (5mg).
Amitriptyline belongs to the class of medicine called Tricyclic antidepressants (TCAs). Amitriptyline works by increasing the levels of chemical messengers in the brain by preventing its reuptake. Increased level of serotonin and noradrenaline helps regulate mood and treat depressive symptoms.
Chlordiazepoxide is a benzodiazepine class of medicine that acts as a GABA-A (Gamma Amino Butyric Acid) receptor agonist. GABA is an inhibitory neurotransmitter, and by binding to the GABA-A receptor, this medicine enhances the inhibitory effects of GABA, resulting in sedative, anti-anxiety and muscle relaxant properties....
Directions for Use of Amize Tablets
- Take an Amize tablet exactly as prescribed by the doctor.
- Take an Amize tablet with or without food or as prescribed by the doctor.
- Take an Amize tablet on a regular schedule, preferably at the same time every day.
- Take an Amize tablet as a whole orally with a full glass of water. Do not crush the tablet or chew this medicine.
- Do not take an Amize tablet with other medications without consulting your doctor.
- Do not suddenly stop taking the Amize tablet, as it may lead to withdrawal side effects.
- Do not exceed the dosage of Amize tablet on your own.
Interactions of Amize Tablets
Interactions with other medicines
- Food does not influence the effect of the Amize tablet. However, it would be best to avoid caffeine-containing diets like tea, coffee, grapefruit and its juice as it may reduce the effectiveness of the Amize tablet....
Interactions with food items
- Many medicines can interact with Amize tablets, making them less effective or increasing side effects. This includes
- Amize tablet interaction with MAOI (monoamine oxidase inhibitors) like Selegiline, Rasagiline, Isocarboxazid and other antidepressants, Lithium, Triptans, Buspirone, Amphetamines, Tramadol, Tryptophan, may cause serotonin syndrome, and these medicines should not be used concomitantly....
- Amize tablet interaction with antidepressants or mood-elevating medicines like Fluoxetine and Desipramine can increase the side effects.
- Amize tablet interaction with antifungal medications like Itraconazole, Fluconazole, and Ketoconazole can reduce its effects.
- Amize tablet interaction with antipsychotics (pimozide, haloperidol) and antihistamines can prolong QT interval (ECG reading) and may alter heart rhythm.
- NSAIDs, aspirin, and other medications that affect coagulation may interact with Amize tablets and increase the risk of bruising or bleeding.
- Amize tablet interaction with Herbal products like St John’s wort can lead to life-threatening side effects.
Storage and disposal of Amize Tablets
Store Amize tablet at room temperature in a cool and dry area, away from direct sunlight. Keep the medication away from children and pet animals.
Do not remove the Amize tablet from its packing and store it within its original packaging.
Do not throw the medicines down into the toilet or dustbin. Medications disposed of in this manner may contaminate the environment.
Properly dispose of Amize tablet when it is expired or no longer required....
Dosage of Amize Tablets
Overdose
Amize tablet overdose can cause confusion, agitation, sleepiness, raised heart rate, low blood pressure, irregular heart rate, dilated pupils, dry mouth, inability to pass urine, seizures, coma, etc. In the case of an overdose of Amize tablet or if you experience these symptoms, seek emergency medical treatment....
Missed a Dose
If you have missed a dose of Amize tablet, take it as soon as you remember. However, if you remember missing a dose of this tablet when it is already time to take the next one, skip the missed dose and take the next scheduled dose. Do not take both doses together as it can cause overdose side effects. Consult your doctor if you have further queries about the dosage of the Amize tablet....
Content Details
WRITTEN BY
Dr. Zishan Ahmad
Final year MBBS Student
REVIEWED BY
Dr. Varsha Parihar
MBBS, MD (Community Medicine)
Frequently Asked Questions (FAQs)
Q: I feel my depressive symptoms are gone. Can I discontinue the Amize tablet on my own?
A: Do not stop the Amize tablet on your own; otherwise, suddenly stopping the medicine may cause withdrawal symptoms, including diarrhoea, vomiting, sweating, confusion, depression, nervousness, and irritability, or may worsen your disease. Consult your doctor before stopping taking the Amize tablet, as doses need to be slowly tapered off to avoid unwanted effects.
Q: Does taking an Amize tablet affects my sexual life?
A: Amize tablets can cause side effects that can lead to decreased sexual drive, problems getting an erection and ejaculating, difficulty achieving orgasm in women. However, these side effects usually resolve on their own after a couple of weeks. However, if you experience these side effects for a longer duration, consult your doctor.
Q: Does the Amize tablet possess habit-forming properties?
A: Some data have shown that the Amize tablet can be mildly habit-forming when used for a long time. The usage of the medication should not be stopped by the patient on their own, and the dosage should be tapered off gradually over time. Consult your doctor for more information.
References
View All
- DailyMed - Chloridiazepoxide and Amitriptyline Hydrochloride tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2022 [cited 12 March 2022].
- Limbitrol, Limbitrol DS (chlordiazepoxide-amitriptyline) dosing, indications, interactions, adverse effects, and more [Internet]. Reference.medscape.com. 2022 [cited 12 March 2022].
- CDSCO [Internet]. Cdscoonline.gov.in. 2022 [cited 12 March 2022].
- [Internet]. 2022 [cited 12 March 2022].
- [Internet]. Rxlist.com. 2022 [cited 12 March 2022].
- Amitriptyline: an antidepressant medicine [Internet]. nhs.uk. 2022 [cited 12 March 2022].
- [Internet]. Accessdata.fda.gov. 2022 [cited 12 March 2022].
Product Details
Brand
AMIZE
Expires on or After
19/07/2024
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Disclaimer
The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.
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