Amize Tablets
Amize Tablets Description
Amize tablet is a prescription medicine mainly used to treat moderate to severe depression. Depression is a type of mood disorder characterised by an episode of sadness, mood swings, loss of interest
, hopelessness, etc. Amize tablet is a combination of two components: Amitriptyline and Chlordiazepoxide. Amitriptyline is an antidepressant that works by increasing the levels of chemical messengers in the brain, which helps regulate mood and also treats depression. Chlordiazepoxide increases the inhibitory effects of a neurotransmitter called GABA (gamma-aminobutyric acid) and produces sedating and calming effects. Amize tablets should be taken only after consulting a doctor. Many side effects are associated with this medicine, so the dosage must be carefully monitored. Complete the entire course of treatment and do not stop taking this medicine suddenly without consulting the doctor, as it can cause clinical worsening of your condition or may lead to withdrawal-like symptoms.
Product Summary
Offer Price | ₹38.72 |
You Save | ₹5.28 (12% on MRP) |
Contains | Amitriptyline |
Uses | Moderate to severe depression associated with anxiety |
Side effects | Drowsiness, Dry mouth, Nasal congestion, Blurred vision, Constipation, Weight gain, Sexual dysfunction |
Therapy | ANTI-DEPRESSANT |
Uses of Amize Tablets
- As per CDSCO and USFDA, the Amize tablet is used for the following:
- Treatment of moderate to severe depression
Contraindications of Amize Tablets
- It is contraindicated in the following cases:
- If you are allergic to any components of Amize tablet, i.e. Amitriptyline or Chlordiazepoxide
- If you are taking medicines like Monoamine Oxidase Inhibitors (MAOIs) and antipsychotic medications or using other anti-anxiety or sedative medicines
- If you have glaucoma (increases the fluid pressure in the eyes)
- If you recently had a heart condition like a heart attack or myocardial infarction
- If you have a history of seizure or epilepsy
- If you have liver or kidney disease
- If you have respiratory issues like asthma or sleep apnea
- If you are a pregnant or breastfeeding mother
Side effects of Amize Tablets
- Side effects of Amize tablets include the following:
- Drowsiness
- Dry mouth
- Nasal congestion
- Blurred vision
- Constipation
- Weight gain
- Sexual dysfunction
Precautions and Warnings of Amize Tablets
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have any allergic reactions after taking the Amize tablet.
- You notice any suicidal ideation or self-harming thoughts.
- You experience sudden or severe changes in thought, behaviour or mood.
- You notice serotonin syndrome-like symptoms.
- You are pregnant or planning for it.
- You are over 65 years; the dose of this medicine should be carefully monitored to prevent serious side effects.
- You are using any ayurvedic/herbal medicines, vitamins and other health supplements.
Mode of Action of Amize Tablets
How Does It Work?
Directions for Use of Amize Tablets
- Take an Amize tablet exactly as prescribed by the doctor.
- Take an Amize tablet with or without food or as prescribed by the doctor.
- Take an Amize tablet on a regular schedule, preferably at the same time every day.
- Take an Amize tablet as a whole orally with a full glass of water. Do not crush the tablet or chew this medicine.
- Do not take an Amize tablet with other medications without consulting your doctor.
- Do not suddenly stop taking the Amize tablet, as it may lead to withdrawal side effects.
- Do not exceed the dosage of Amize tablet on your own.
Interactions of Amize Tablets
Interactions with other medicines
- Food does not influence the effect of the Amize tablet. However, it would be best to avoid caffeine-containing diets like tea, coffee, grapefruit and its juice as it may reduce the effectiveness of the Amize tablet....
Interactions with food items
- Many medicines can interact with Amize tablets, making them less effective or increasing side effects. This includes
- Amize tablet interaction with MAOI (monoamine oxidase inhibitors) like Selegiline, Rasagiline, Isocarboxazid and other antidepressants, Lithium, Triptans, Buspirone, Amphetamines, Tramadol, Tryptophan, may cause serotonin syndrome, and these medicines should not be used concomitantly....
- Amize tablet interaction with antidepressants or mood-elevating medicines like Fluoxetine and Desipramine can increase the side effects.
- Amize tablet interaction with antifungal medications like Itraconazole, Fluconazole, and Ketoconazole can reduce its effects.
- Amize tablet interaction with antipsychotics (pimozide, haloperidol) and antihistamines can prolong QT interval (ECG reading) and may alter heart rhythm.
- NSAIDs, aspirin, and other medications that affect coagulation may interact with Amize tablets and increase the risk of bruising or bleeding.
- Amize tablet interaction with Herbal products like St John’s wort can lead to life-threatening side effects.
Storage and disposal of Amize Tablets
Dosage of Amize Tablets
Overdose
Missed a Dose
Content Details
Dr. Zishan Ahmad
MBBS, MD
Dr. Varsha Parihar
MBBS, MD (Community Medicine)
Frequently Asked Questions (FAQs)
Q: I feel my depressive symptoms are gone. Can I discontinue the Amize tablet on my own?
Q: Does taking an Amize tablet affects my sexual life?
Q: Does the Amize tablet possess habit-forming properties?
References
- DailyMed - Chloridiazepoxide and Amitriptyline Hydrochloride tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2022 [cited 12 March 2022].
- Limbitrol, Limbitrol DS (chlordiazepoxide-amitriptyline) dosing, indications, interactions, adverse effects, and more [Internet]. Reference.medscape.com. 2022 [cited 12 March 2022].
- CDSCO [Internet]. Cdscoonline.gov.in. 2022 [cited 12 March 2022].
- [Internet]. 2022 [cited 12 March 2022].
- [Internet]. Rxlist.com. 2022 [cited 12 March 2022].
- Amitriptyline: an antidepressant medicine [Internet]. nhs.uk. 2022 [cited 12 March 2022].
- [Internet]. Accessdata.fda.gov. 2022 [cited 12 March 2022].
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