Acedase Tablet
Description
Acedase tablet is used to relieve acute pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis in adults. It contains aceclofenac, which blocks pain-causing chemicals in the body, and serratiopeptidase, which helps reduce swelling and break down harmful tissue. Together, they help manage pain, fever, and inflammation.
You should not take Acedase tablet if you have allergies to its ingredients, a history of stomach ulcers or bleeding, severe heart, kidney, or liver problems, or are pregnant. Common side effects include dizziness, nausea, stomach pain, and allergic reactions. Always take the tablet as directed, with or without food, and at the same time each day for best results.
This medicine may interact with several other medications, including blood thinners, blood pressure medications, heart medications, lithium, methotrexate, and certain antibiotics or antidepressants. These combinations can raise the risk of bleeding, kidney issues, or other serious side effects. Let your doctor know about all medications or supplements you’re taking.
Avoid Acedase tablet during pregnancy and breastfeeding unless your doctor advises otherwise. Do not drive if you feel dizzy or sleepy after taking it. Avoid alcohol while on this medicine. If you miss a dose, take it as soon as you remember, but don’t double up. In case of overdose, seek medical help immediately.
Product Summary
Offer Price | ₹136.80 |
You Save | ₹43.20 (24% on MRP) |
Contains | Aceclofenac(100.0 Mg)+Serratiopeptidase(15.0 Mg) |
Uses | Osteoarthritis, Rheumatoid arthritis and Ankylosing spondylitis |
Side effects | Dizziness, upset stomach, abdominal pain |
Therapy | ANALGESIC/ANTIPYRETIC |
Uses
Contraindications
- If you are allergic to aceclofenac, serratiopeptidase or any other ingredients of the Acedase tablet.
- If you have a current or repeated history of stomach ulcers or bleeding.
- If you've ever had breathing problems, a runny nose, swelling (like angioedema), or skin rashes (like hives) after taking painkillers like ibuprofen, aspirin, or other NSAIDs.
- If you have active bleeding or a condition that makes you bleed easily, this medicine is not safe for you.
- If you have renal or hepatic diseases.
- If you have severe heart failure, heart disease, poor circulation in the legs or arms, or a history of stroke, this medicine may not be suitable for you.
- If you’ve had stomach bleeding or a hole in your stomach while using other NSAIDs before.
- If you are pregnant.
Side effects
- Dizziness
- Upset stomach
- Abdominal pain
- Nausea
- Diarrhoea
- Vomiting
- Allergic reactions
Precautions and Warnings
Other General Warnings
- You take other painkillers like aspirin or ibuprofen, or medicines for high blood pressure, such as ACE inhibitors.
- You take water pills (diuretics), heart medicines like digoxin, or lithium for mental health.
- You take methotrexate, mifepristone, steroids, blood thinners (like warfarin or clopidogrel), certain antibiotics (like quinolones), antidepressants, transplant drugs (like ciclosporin or tacrolimus), or zidovudine for HIV....
- You take diabetic medications; aceclofenac may affect your blood sugar levels. Watch for signs of low or high blood sugar.
Pregnancy
Driving
Breast Feeding
Alcohol
Directions for Use
- The tablet can be taken with or without food and swallowed whole with water.
- Take it at the same time for better results.
Storage and disposal
- Store in a cool, dry place, away from direct sunlight.
- Keep it out of reach of children and pets.
Dosage
Missed a Dose
Overdose
- If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
- Taking too much of this medicine can be dangerous. It may cause symptoms like headache, nausea, vomiting, stomach pain, dizziness, ringing in the ears, sleepiness, confusion, or even fainting and seizures. In severe cases, it can lead to kidney failure, liver damage, or trouble breathing. Always follow the prescribed dose and seek medical help right away if too much is taken....
Mode of Action
How Does It Work?
- Aceclofenac works by blocking a substance in the body (called COX-2) that helps make chemicals called prostaglandins. These chemicals cause pain, swelling, and fever. By reducing them, aceclofenac helps relieve pain, reduce inflammation, and lower fever....
- Serratiopeptidase may reduce inflammation by affecting the movement and adhesion of immune cells. It may also help clear blood clots and plaque in arteries by breaking down harmful tissue without damaging healthy cells....
Interactions
Interactions with other medicines
- If administered along with Warfarin, Clopidogrel or Aspirin as well as with other natural remedies such as garlic, fish oil and turmeric, there may be an increased risk of bleeding or bruising.
- Medicines for high blood pressure or water pills may not work as well and can increase the risk of kidney problems, especially in elderly or dehydrated patients.
- Heart medications like digoxin may accumulate in the body and exacerbate heart problems.
- Combining with lithium, methotrexate, or transplant medicines can increase side effects, particularly on the kidneys.
- Using Acedase tablet within 8–12 days after mifepristone may reduce its effectiveness.
- Steroids, blood thinners, antidepressants, and certain antibiotics can raise the risk of bleeding, stomach issues, or seizures.
- Zidovudine (used in HIV treatment) may increase the risk of bleeding problems.
- Diabetes medicines may need dose adjustments as aceclofenac could affect blood sugar levels.
Content Details

Ravindra Ghongade
B. Pharm

Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: Can I stop taking the medication once I feel better?
Q: Can Acedase tablet be given to children?
Q: Can I take Acedase tablet without food?
References
- U.S. Food and Drug Administration. New dietary ingredient (NDI) safety information: Serratiopeptidase [Internet]. Silver Spring (MD): FDA; 2021 [cited 2025 Jun 9].
- Rivopharm UK Ltd. Aceclofenac 100 mg Film-coated Tablets SmPC [Internet]. 2023 Sep 7 [cited 2025 Jun 9].
- Central Drugs Standard Control Organisation. Drugs. [Internet]. New Delhi: Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India; [cited 2025 Jun 9].
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