Vonoprazan
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Molecule Summary
| Uses | Esophagitis, Heartburn, Helicobacter pylori (H. pylori) Infection |
| Therapy | Antacid And Anti-Reflux |
| Side Effects | Diarrhea, stomach pain, nausea, high blood pressure, indigestion |
Medicines
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19k pincodes
Molecule Description
Vonoprazan is used for the treatment and prevention of sores in the lining of the stomach or intestine. It contains vonoprazan as the main ingredient, which lowers the amount of acid the stomach makes.
Vonoprazan is a medication that reduces stomach acid by blocking a specific enzyme in the stomach cells known as the proton pump. This process halts the final step of acid production. Unlike other medications, vonoprazan does not require stomach acid to function and can accumulate in the stomach cells regardless of their activity. It binds to the proton pumps temporarily, allowing it to work effectively.
Take this medicine with plenty of water. You may take it with or without food. Common side effects of Vonoprazan include diarrhoea, stomach pain, nausea, high blood pressure, and indigestion. If you experience any of these symptoms, it is essential to consult your healthcare provider.
Uses
Vonoprazan is used to heal damage to the esophagus caused by excess stomach acid and alleviate associated heartburn. It also helps prevent further damage and recurrence of heartburn after healing. When prescribed with other antibiotics, it aids in eliminating Helicobacter pylori bacteria, which can lead to stomach ulcers.
Contraindications
When should one not use Vonoprazan
- If you have an allergic reaction to Vonoprazan or any of its other ingredients.
- If you are using Rilpivirine-containing compounds. Rilpivirine can interact with certain other medications, especially those that reduce stomach acid, such as Vonoprazan. If you take acid-reducing medicines, it could make Rilpivirine less effective, so it may not work as well in your body.
Side effects
Common side effects of this drug are:
The common side effects of Vonoprazan are diarrhoea, stomach pain, nausea, high blood pressure and indigestion.
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Mode of Action
How Does It Work?
Vonoprazan is a potassium-competitive acid blocker (P-CAB) that inhibits the H+/K+-ATPase enzyme in gastric parietal cells, reducing gastric acid secretion. Unlike proton pump inhibitors (PPIs), it does not require acidic activation, resulting in a rapid onset and sustained acid suppression. This mechanism offers faster and more consistent control of gastric pH, providing a significant advantage in treating acid-related disorders.
Interactions
Interactions with other medicines
- Medicines such as Rilpivirine, Nelfinavir and Atazanavir (used to treat HIV/ AIDS).
- If you take Vonoprazan, it may reduce the effectiveness of Rilpivirine, so it may not work as well in your body.
- Medicines that need more amount of acid in the stomach to work, such as Iron salts, Erlotinib, Dasatinib, Nilotinib, Mycophenolate mofetil, and Ketoconazole/Itraconazole. Vonoprazan reduces the effect of these medicines in the body.
- Tell your doctor about all the medicines, supplements and/or herbals you are currently taking or might take to avoid any possible interaction. Especially if you are taking medicines to treat HIV/ AIDS.
Dosage
Overdose
If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
If a dose is missed within 12 hours, take it as soon as possible; otherwise, skip the missed dose and resume your regular schedule. For infection treatment, take a missed dose within 4 hours; if it is more than 4 hours, skip it and continue with the regular schedule. In all cases, never double the next dose to compensate for a missed one.
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