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Varenicline

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Molecule Summary

Uses
Smoking cessation
Therapy
Deaddiction
Side Effects
Nausea, headache, dizziness, sleep problems, unusual dreams
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Molecule Description

Varenicline is a prescription medicine used to help you stop smoking. It is suitable for adults who are motivated to quit and need medical support to manage nicotine cravings and withdrawal symptoms. When you stop smoking, your body may react with irritability, restlessness, low mood, sleep problems, or strong urges to smoke. Varenicline helps reduce these symptoms and also lowers the satisfaction you may feel if you smoke during treatment, making it easier for you to stay committed to quitting. It should be used along with medical guidance and regular follow-up from your doctor. Varenicline works by acting on specific receptors in your brain that are involved in nicotine dependence. It partially stimulates these receptors to reduce cravings and withdrawal discomfort, while also blocking nicotine from cigarettes so that smoking feels less rewarding. This supports your effort to quit smoking and helps prevent relapse. Because quitting smoking itself can affect your mood and behaviour, it is important to monitor how you feel during treatment and inform your doctor about any concerning changes. You should take Varenicline exactly as advised by your doctor. Treatment usually starts with a low dose that is gradually increased over the first week to allow your body to adjust and to reduce side effects like nausea. The medicine should be taken with water and can be taken with or without food. Try to take it at the same time each day. Your doctor will usually advise a treatment duration of about 12 weeks, which may be extended if needed to help you remain smoke-free. Varenicline may cause side effects, although not everyone gets them. Commonly reported side effects include nausea, headache, dizziness, sleep problems, unusual dreams, constipation, diarrhoea, dry mouth, and tiredness. Some people may notice changes in mood, anxiety, or low mood while quitting smoking. If you experience severe side effects or any changes in mood or behaviour that worry you, contact your doctor immediately.

Uses

  • Management of nicotine addiction/smoking cessation in adults
  • Reduces craving for cigarettes
  • Eases withdrawal symptoms after stopping smoking
  • Lowers the enjoyment of smoking if you relapse during treatment

Contraindications

When should one not use Varenicline

  • If you are allergic to varenicline or any of the other ingredients of this medicine
  • If you have had a serious allergic reaction, such as swelling of the face, lips, tongue, or throat, after taking varenicline earlier
  • If you have experienced severe skin reactions like blistering, peeling, or painful rashes after using varenicline

Side effects

Common side effects of this drug are:

  • Feeling nauseous or sick
  • Headache or dizziness
  • Trouble sleeping or unusual dreams
  • Constipation, diarrhoea, or stomach discomfort
  • Dry mouth and feeling tired

Precautions and Warnings

Pregnancy

Pregnancy

It is preferable to avoid Varenicline during pregnancy. If you are pregnant, planning to become pregnant, or think you may be pregnant, consult your doctor for safer alternatives.

Breast Feeding

Breast Feeding

It is not known whether Varenicline passes into breast milk. Speak to your doctor before using it while breastfeeding.

Driving

Driving

Varenicline may cause dizziness, sleepiness, or a brief loss of consciousness. Avoid driving or operating machinery until you know how it affects you.

Alcohol

Alcohol

It is recommended to limit or avoid alcohol when taking Varenicline, and to discuss this with your doctor.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have kidney disease, have had a kidney transplant, or have liver disease
  • You have a history of depression, anxiety, or any other mental health condition
  • You notice changes in mood, behaviour, or thoughts of self-harm while taking Varenicline
  • You have heart disease or have had a heart attack or stroke earlier
  • You have a history of seizures or epilepsy
  • You experience chest pain, shortness of breath, or sudden weakness on one side of the body
  • You develop a skin rash, blistering, peeling of skin, or sores in the mouth or eyes
  • You have swelling of the face, lips, tongue, or throat, or difficulty breathing
  • You feel unusually dizzy, very sleepy, or have a brief loss of consciousness
  • You consume alcohol regularly or notice increased effects of alcohol while on Varenicline
  • You are pregnant, planning to become pregnant, or breastfeeding
  • You are taking other medicines and are unsure if they are safe to use with Varenicline

Mode of Action

How Does It Work?

Varenicline works on specific receptors in your brain that are involved in nicotine addiction. It reduces the rewarding effect of nicotine from cigarettes and helps control cravings and withdrawal symptoms, making quitting smoking more manageable.

Interactions

Interactions with food items

Varenicline can be taken with or without food.

Dosage

Overdose

If you take more Varenicline than prescribed, seek medical help immediately or visit the nearest hospital. Carry the medicine pack with you.

Missed a Dose

If you forget a dose, take it as soon as you remember. If it is close to your next dose, skip the missed one. Do not take a double dose to make up for a missed one.

Frequently Asked Questions (FAQs)

Take it for 12 weeks as prescribed by your doctor. Your doctor may recommend continuing for another 12 weeks to help prevent relapse. Regular follow-ups with your doctor are recommended.

You may reduce smoking during the first 12 weeks and aim to quit by the end of that period. Always follow your doctor's advice.

Some people may experience mood changes, anxiety, or low mood while quitting smoking, with or without Varenicline. If you notice changes in behaviour, persistent sadness, agitation, or unusual thoughts, contact your doctor immediately. Do not ignore these symptoms, as early medical advice can help manage them safely.

You may still smoke during the first few days of treatment, but you should aim to stop by the quit date decided with your doctor. Varenicline reduces the pleasure you get from smoking, which helps you gradually quit. Try to follow the plan given by your doctor for the best outcome.

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