Tirzepatide
Description
Tirzepatide is a prescription medication used to improve blood sugar control in
adults with type 2 diabetes when used alongside diet and exercise. It is also indicated for weight management when used in conjunction with a reduced-calorie diet and increased physical activity. While taking Tirzepatide, you may experience common side effects such as nausea, diarrhoea, vomiting, constipation, stomach pain, or indigestion. These effects are usually mild and often improve over time; however, if they become severe or persist, it is advisable to consult your doctor. Importantly, Tirzepatide should not be used if you or your family have a history of a specific type of thyroid cancer called medullary thyroid carcinoma or a condition known as multiple endocrine neoplasia syndrome type 2 (MEN2). Additionally, it is recommended that pregnant individuals or those planning a pregnancy avoid this medication due to potential risks to the baby. Always inform your doctor about all other medications you are taking before starting Tirzepatide to prevent possible interactions.
Uses
Contraindications
When should one not use Tirzepatide
Side effects
Common side effects of this drug are:
- Abdominal pain
- Constipation
- Indigestion
- Nausea
- Diarrhea
- Vomiting
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
- You have a history of pancreatitis.
- You experience severe abdominal pain, nausea, or vomiting, which could indicate pancreatitis.
Mode of Action
How Does It Work?
Interactions
Interactions with other medicines
- Taking oral medications with a narrow therapeutic index, such as warfarin or digoxin, may be affected by tirzepatide, as it can alter their absorption.
- Using medications that require a rapid onset of action might be problematic since tirzepatide may delay their effects.
- Relying on oral contraceptives may be risky, as tirzepatide could reduce their effectiveness. It is advisable to consider switching to a non-oral contraceptive method or to use additional protection for four weeks after starting tirzepatide or increasing its dose....
- Having obesity or being overweight while using oral contraceptives may be concerning since tirzepatide can influence their efficacy.
- Frequent use of paracetamol may be impacted by tirzepatide, as it may delay its absorption; however, no dose adjustment is typically necessary.
Content Details

Ravindra Ghongade
B. Pharm

Dr. Nikita Toshi
BDS (Bachelor of Dental Surgery), WHO FIDES member
Frequently Asked Questions (FAQs)
Q: What is Tirzepatide, and what is it used for?
Q: How does Tirzepatide work?
Q: Is Tirzepatide an insulin?
Q: Can Tirzepatide cause low blood sugar (hypoglycemia)?
Q: Who should not use Tirzepatide?
Q: Can Tirzepatide be used during pregnancy or breastfeeding?
Q: Do I have to take Tirzepatide for the rest of my life?
Q: What happens when you stop taking Tirzepatide?
Q: Can I take Tirzepatide with other diabetes medications?
Q: Are there any precautions to follow while taking Tirzepatide?
- Yes, some important precautions include:
- Monitor for low blood sugar if you're taking other diabetes medications.
- Stay hydrated, particularly if you experience stomach upset.
- Avoid or limit alcohol, as it can increase the risk of low blood sugar or dehydration.
- Inform your doctor if you have a history of pancreatitis, kidney disease, or severe gastrointestinal issues.
- If you're undergoing surgery, notify your doctor that you are taking Tirzepatide, as it can slow stomach emptying and may need to be suspended beforehand.
- For women using oral birth control, discuss alternative or additional contraception with your doctor.
References
- Farzam K, Patel P. Tirzepatide. [Updated 2024 Feb 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
- Dutta P, Kumar Y, Babu AT, Giri Ravindran S, Salam A, Rai B, Baskar A, Dhawan A, Jomy M. Tirzepatide: A Promising Drug for Type 2 Diabetes and Beyond. Cureus. 2023 May 1;15(5):e38379. doi: 10.7759/cureus.38379. PMID: 37265914; PMCID: PMC10231274.
- Lilly.com | Eli Lilly and Company [Internet]. www.lilly.com. [Cited 4 June 2025]
- Mounjaro KwikPen 2.5mg solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. [Cited 4 June 2025]
- MOUNJAROTM (tirzepatide) Injection, for subcutaneous use Initial U.S. Approval: 2022 [Internet]. uspl.lilly.com.[Cited 4 June 2025]