Thalidomide
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Molecule Summary
| Uses | Cancer and Lepra reaction |
| Therapy | Anti-Neoplastic, Drugs For Lepra Reaction |
| Side Effects | Dizziness, sleepiness, constipation, tremor |
Assurance
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Regulated
Molecule Description
Thalidomide is an immunomodulatory medicine. It is used to treat skin reactions caused by leprosy and a type of white blood cell cancer. The medicine works by modulating and strengthening the immune system, while also inhibiting the release of certain chemical substances that cause inflammation and swelling.
Thalidomide acts by inhibiting the growth and multiplication of cancer cells, preventing them from forming their own blood vessels, which ultimately leads to the death of the cancer cells. It should be taken as advised by a doctor, with a glass of water, and at a fixed time every day for optimal results.
Thalidomide should not be used by individuals allergic to thalidomide, and it is strictly prohibited for pregnant women or those planning a pregnancy due to the risk of harm to the unborn baby. Male patients who cannot comply with contraceptive methods should also avoid this medicine.
Common side effects of Thalidomide include dizziness, sleepiness, constipation, and peripheral swelling. It may also lead to tremors, anaemia, or a decreased blood count. Patients should avoid driving after taking this medicine and should not consume alcohol, as it may worsen the side effects.
Uses
- Used to treat skin reactions caused due to leprosy.
- It is also used to treat white blood cell cancer.
Contraindications
When should one not use Thalidomide
- If you are allergic to thalidomide or any other ingredient of this medicine.
- If you are pregnant, planning pregnancy or of childbearing age.
- If male patients are unable to comply with the contraceptive method.
Side effects
Common side effects of this drug are:
- Dizziness
- Sleepiness
- Constipation
- Peripheral swelling
- Tremors
- Anaemia
- Decreased blood count
- Abnormal sensations such as pricking and tingling
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You are above 50 years of age, menopausal or of non-childbearing age.
- You are using any kind of contraceptive method.
- You are pregnant or breastfeeding.
- You have heart disease or conditions.
- You have thyroid or a blood disorder.
- You have kidney or liver damage.
- You experience an allergic reaction after taking Thalidomide.
- You have or experience a tingling sensation or numbness of the extremities.
- You have or had any kind of cancer or cancer lysis.
- You have any active infections.
- You feel sleepy or dizzy.
Mode of Action
How Does It Work?
Thalidomide acts by inhibiting the growth and multiplication of cancer cells and stops cancer cells from making their own blood vessels. Thus, kills the cancer cells. It also modulates the immune system of the body.
Interactions
Interactions with other medicines
- Some medicines can affect the way Thalidomide works, or Thalidomide itself may reduce the effectiveness of other medicines taken at the same time.
- Inform the doctor about other medicine, herbal preparation and supplements you are taking to avoid possible interactions.
- Especially if you are taking oral contraceptive medicines, blood thinners, anti-allergic medicine, other cancer medicine or medicine used to treat brain-related disorders.
- If you are taking digoxin.
Interactions with food items
- Take Thalidomide with or without food.
- Taking it with food may help reduce stomach irritation.
- Avoid grapefruit and grapefruit juice, as they may affect how the medicine works.
- Alcohol should be avoided, as it may increase the risk of liver-related side effects.
- Maintain a balanced diet to support overall health during treatment.
- Stay hydrated by drinking enough water throughout the day.
Dosage
Overdose
An overdose of Thalidomide may cause drowsiness, irritability, nausea, and headache. If you think you have taken too much of this medicine, contact your doctor immediately or visit the nearest hospital.
Missed a Dose
Missing a dose of Thalidomide may reduce the effectiveness of the treatment. If you missed a dose of this medicine, take it as soon as you remember. If it's time for your next dose, then skip the missed dose and continue with your regular dose schedule. Do not take a double dose of medicine to compensate for the missed one.
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