Teneligliptin

When should one not use Teneligliptin

• If you are allergic to teneligliptin or similar medicines
• If you are to undergo surgery or are suffering from a serious physical injury and insulin injection is being used to control your blood sugar.
• If your blood sugar levels are uncontrolled and complications like ketosis (serious metabolism-related problem), diabetic coma or pre-coma have developed.

Common side effects of this drug are:

• Dizziness
• Headache
• Diarrhoea
• Increased body temperature
• Low blood sugar levels

Other General Warnings

• You have problems with your heart, liver or kidneys.
• You have a known history of pancreatitis, or you develop sudden pain in the stomach or back.
• You are taking other medicines to treat diabetes like insulin and glimepiride.
• You have undergone any stomach or intestine operation.
• You are malnourished, are on a diet, are having irregular meals, exercising vigorously or consume alcohol in excess.

How Does It Work?

• While eating, glucose concentration increases in our bodies.
• In response to that small intestine increases the release of certain chemicals called incretins.
• These play an important role in controlling blood glucose.
• But these are rapidly degraded by an enzyme (DPPP-4).
• Teneligliptin inhibits the action of DPP-4 enzymes and slows down the rapid degradation of incretins.
• It also increases insulin synthesis by the pancreas and decreases glucagon levels which are a counter-hormone of insulin, thereby further decreasing blood sugar levels.

Interactions with other medicines

• Some medicines can affect the way teneligliptin works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
• Especially if you are taking medicines to treat diabetes, heart problems, psychiatric illnesses, high blood pressure, thyroid problems, fever and pain (salicylates like aspirin), are taking steroids, adrenaline.
• Medicines used for the treatment of heart rhythm disorder should be used with caution while taking teneligliptin.

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