Sorafenib

When should one not use Sorafenib

Common side effects of this drug are:

• Diarrhoea
• Nausea
• Vomiting
• Fatigue
• Pain (including mouth pain, abdominal pain, headache, bone pain, tumour pain)
• Hair loss (alopecia)
• Flushed or painful palms or soles (hand-foot skin reaction)
• Itching or rash
• Bleeding (including bleeding in the brain, gut wall, and airways)
• Hypertension
• Infections
• Loss of appetite (anorexia)
• Constipation
• Joint pain (arthralgia)
• Fever
• Weight loss
• Dry skin

Other General Warnings

• You experience skin problems.
• You have high blood pressure.
• You have or have had an aneurysm (enlargement and weakening of a blood vessel wall) or a tear in a blood vessel wall.
• You have diabetes, and your blood sugar levels should be checked regularly.
• You have any bleeding problems, or you are taking warfarin or phenprocoumon.
• You have chest pain or heart problems, and your doctor may interrupt or stop treatment.
• You have a heart disorder, such as an abnormal electrical signal called "prolongation of the QT interval."
• You are going to have surgery or have had an operation recently.
• You are taking irinotecan or docetaxel (other cancer medicines).
• You are taking Neomycin or other antibiotics.
• You have severe liver impairment.
• You have poor kidney function.
• You have thyroid cancer.
• You experience nausea, shortness of breath, irregular heartbeat, muscular cramps, seizures, cloudy urine, and tiredness. These could be signs of a serious condition called Tumour lysis syndrome (TLS). Contact your doctor immediately.

How Does It Work?

Interactions with other medicines

• Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. This includes medicines you bought without a prescription.
• Specifically, tell your doctor if you are taking any of the following:
• Rifampicin, neomycin, or other antibiotics (used to treat infections).
• St John's wort, a herbal treatment for depression.
• Phenytoin, carbamazepine, or phenobarbital, treatments for epilepsy and other conditions.
• Dexamethasone, a corticosteroid used for various conditions.
• Warfarin or phenprocoumon, anticoagulants used to prevent blood clots.
• Doxorubicin, capecitabine, docetaxel, paclitaxel, and irinotecan, which are cancer treatments.
• Digoxin, a treatment for mild to moderate heart failure.
• The effect of Sorafenib may be decreased if you are taking Neomycin or other antibiotics. Sorafenib may increase the side effects of irinotecan and docetaxel.

Interactions with food items

• Take Sorafenib on an empty stomach, at least 1 hour before or 2 hours after meals.
• Avoid high-fat meals before or after taking Sorafenib, as they may interfere with its absorption.
• Limit grapefruit or grapefruit juice, as it may interfere with the metabolism of the medicine.
• Stay hydrated and maintain a balanced diet to help reduce gastrointestinal side effects.
• Avoid alcohol, as it can increase the risk of liver-related side effects.

Overdose

Missed a Dose