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Silodosin

Molecule Description

Silodosin is a medicine that blocks the alpha receptors present on walls of arteries and certain types of muscle (e.g. prostate) and causes them to relax. The primary function of alpha receptors is to narrow (constrict) and increase the pressure. Silodosin belongs to a group of medicines called ‘anti-adrenergic agents.’
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Uses of Silodosin

Age-related enlargement of the prostate gland which is not cancerous (commonly known as BPH or Benign Prostate Hyperplasia).

Contraindications of Silodosin

When should one not use Silodosin

  • This medicine should not be taken in patients with allergic reaction to Silodosin
  • Other alpha-receptor blockers (e.g. Prazosin, Doxazoin, Terazosin), or any of its components
  • It is not to be used in liver diseases, in patients having low blood pressure or those on Diuretics
  • Severe kidney disease

Side effects of Silodosin

Common side effects of this drug are:

  • Mild dizziness
  • Headache, chills
  • Diarrhea
  • Abnormal ejaculation
  • Running nose, Sore throat
  • Allergic reactions like- fever, chills, rash, hives, breathing difficulty, swelling over your face, lips, throat (serious)
  • Feeling sick
  • Prolonged erection of penis (priapism)

Precautions and Warnings of Silodosin

Pregnancy

Q:
Can I take Silodosin during pregnancy?
A:
This medicine is for use in males only.

Breast Feeding

Q:
Can I take Silodosin while breastfeeding?
A:
This medicine is for use in males only.

Driving

Q:
Can I drive if I have consumed Silodosin?
A:
Silodosin may cause dizziness, lightheadedness or fainting; hence, caution is advised while driving. Do not drive any vehicle in the first few weeks after starting the medication and later on, do not drive for long distances.

Alcohol

Q:
Can I consume alcohol with Silodosin?
A:
Drinking alcohol with Silodosin may increase the risk of side effects so this is not recommended.

Other General Warnings

Talk to your doctor if
  • As Silodosin works by slowing the heart rate, older adults may be more sensitive to the side effects of this medicine, especially dizziness and low blood pressure when getting up from a sitting or lying position
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  • Silodosin must be used with caution in elderly patients and people with liver disease
  • People undergoing cataract surgery should inform their doctor as Silodosin may sometime complicate the procedure

Mode of Action of Silodosin

How Does It Work?

The urine formed in the urinary bladder is eliminated through a tube called urethra, which passes through the prostate gland. In the enlargement of the prostate, the tube is blocked, causing incomplete passage of urine, retention of urine (leading to infections) and pain/ difficulty in passing urine. Silodosin acts by relaxing the enlarged prostate and enables free passage of urine.
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Interactions of Silodosin

Interactions with other medicines

  • Other alpha-receptor blockers - Terazosin, Prazosin, Alfuzosin, Tamsulosin, Doxazosin
  • Medicines used to treat HIV/ AIDS (Fosemprenavir, Atazanavir, Indinavir)
  • Antifungals (Clotrimazole)
  • Antibiotics (Clarithromycin, Dalfopristin/ Quinupristin, Erythromycin)
  • Isoniazid (and antitubercular treatment containing Isoniazid as one of the medicines)
  • Imanitib
  • Blood pressure medications (Diltiazem, Felodipine, Nicardipine, Nifedipine, Verapamil, etc.)
  • Medicines used to suppress the immune system/ prevent organ transplant rejection (Cyclosporine, Sirolimus, Tacrolimus)
  • Medicines used to treat erectile dysfunction (Sildenafil, Tadalafil, Vardenafil)
  • Quinidine (used to treat irregular heartbeats)
  • Conivaptan (used to treat low sodium levels)

Interactions with food items

Dosage of Silodosin with food can reduce the risk or severity of side effects. Therefore, Silodosin is generally given with a meal or immediately after a meal.

Dosage of Silodosin

Overdose

Accidental overdose of Silodosin is not life-threatening. Extreme overdose may cause low blood pressure and medical attention is required. Inform your doctor in case of an overdose.

Missed a Dose

Take the missed dose as soon as you remember. If the time for the next dose is close, skip the missed dose & do not take extra medicine to compensate for the missed dose.

Content Details

WRITTEN BY
doctor

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)

REVIEWED BY
doctor

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

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Q: What should I discuss with my healthcare expert before taking Silodosin?

  • You cannot take Silodosin if you are allergic to it or other medicines of the same group (alpha-receptor blockers) like Prazosin, Terazosin, Doxazosin, etc.
  • Inform your physician if you have severe kidney or liver disease
  • If you have low blood pressure and heart disease
  • If you are on a low salt diet
  • If you are taking any water pill (Diuretic)
  • If you have had a history of prostate cancer

Q: What is BPH or Benign Prostatic Hyperplasia?

  • Prostate is a gland (a secretory organ) that is present between the penis and the bladder. Its primary function is to nourish and transport the semen (male ejaculatory fluid) during the reproductive age
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  • As old age approaches, the prostate gland enlarges in some men due to decreased reproductive hormones and this will lead to inadequate nourishment and enlargement of the gland
  • The prostate can also enlarge in Prostate cancer and hence the name Benign Prostatic Hyperplasia to differentiate it from cancer
  • Benign means ‘not malignant (cancerous)’
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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