Silodosin

Molecule Description

Silodosin is used for the treatment of problems arising due to the enlargement

of the prostate gland, a medical condition known as benign prostatic hyperplasia (BPH). It blocks the alpha receptors present on walls of arteries and certain types of muscle (e.g. prostate) and causes them to relax. The primary function of alpha receptors is to narrow (constrict) and increase the pressure. Silodosin belongs to a group of medicines called ‘anti-adrenergic agents. Dizziness, postural hypotension (a drop in blood pressure after a change of posture), headache, loose motions, and retrograde ejaculation (backward flow of semen/orgasm with less or no semen) are some of the common side effects of Silodosin, but not everybody gets them.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Silodosin

For the treatment of enlargement of the prostate gland, a medical condition known as benign prostatic hyperplasia (BPH).

Contraindications of Silodosin

When should one not use Silodosin

This medicine should not be taken in patients with allergic reaction to Silodosin
Other alpha-receptor blockers (e.g. Prazosin, Doxazoin, Terazosin), or any of its components
It is not to be used in liver diseases, in patients having low blood pressure or those on Diuretics
Severe kidney disease

Side effects of Silodosin

Common side effects of this drug are:

Retrograde ejaculation
Dizziness
Postural hypotension
Headache
Loose motions
Nasal congestion

Precautions and Warnings of Silodosin

Pregnancy

Can I take Silodosin during pregnancy?

This medicine is for use in males only.

Breast Feeding

Can I take Silodosin while breastfeeding?

This medicine is for use in males only.

Driving

Can I drive if I have consumed Silodosin?

Silodosin may cause dizziness, lightheadedness or fainting; hence, caution is advised while driving. Do not drive any vehicle in the first few weeks after starting the medication and later on, do not drive for long distances.

Alcohol

Can I consume alcohol with Silodosin?

Drinking alcohol with Silodosin may increase the risk of side effects so this is not recommended.

Other General Warnings

Talk to your doctor if

As Silodosin works by slowing the heart rate, older adults may be more sensitive to the side effects of this medicine, especially dizziness and low blood pressure when getting up from a sitting or lyi...
Read more
Silodosin must be used with caution in elderly patients and people with liver disease
People undergoing cataract surgery should inform their doctor as Silodosin may sometime complicate the procedure

Mode of Action of Silodosin

How Does It Work?

Silodosin helps relax the muscles in the prostate and in the opening to the bladder. This may help increase the flow of urine or decrease the symptoms. This medicine is usually given only to men.

Interactions of Silodosin

Interactions with other medicines

Other alpha-receptor blockers - Terazosin, Prazosin, Alfuzosin, Tamsulosin, Doxazosin
Medicines used to treat HIV/ AIDS (Fosemprenavir, Atazanavir, Indinavir)
Antifungals (Clotrimazole)
Antibiotics (Clarithromycin, Dalfopristin/ Quinupristin, Erythromycin)
Isoniazid (and antitubercular treatment containing Isoniazid as one of the medicines)
Imanitib
Blood pressure medications (Diltiazem, Felodipine, Nicardipine, Nifedipine, Verapamil, etc.)
Medicines used to suppress the immune system/ prevent organ transplant rejection (Cyclosporine, Sirolimus, Tacrolimus)
Medicines used to treat erectile dysfunction (Sildenafil, Tadalafil, Vardenafil)
Quinidine (used to treat irregular heartbeats)
Conivaptan (used to treat low sodium levels)

Content Details

WRITTEN BY

Dr. Nikita Toshi

BDS (Bachelor of Dental Surgery)

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What should I discuss with my healthcare expert before taking Silodosin?

You cannot take Silodosin if you are allergic to it or other medicines of the same group (alpha-receptor blockers) like Prazosin, Terazosin, Doxazosin, etc.
Inform your physician if you have severe kidney or liver disease
If you have low blood pressure and heart disease
If you are on a low salt diet
If you are taking any water pill (Diuretic)
If you have had a history of prostate cancer

Q: What is BPH or Benign Prostatic Hyperplasia?

Prostate is a gland (a secretory organ) that is present between the penis and the bladder. Its primary function is to nourish and transport the semen (male ejaculatory fluid) during the reproductive a...
Read more
As old age approaches, the prostate gland enlarges in some men due to decreased reproductive hormones and this will lead to inadequate nourishment and enlargement of the gland
The prostate can also enlarge in Prostate cancer and hence the name Benign Prostatic Hyperplasia to differentiate it from cancer
Benign means ‘not malignant (cancerous)’

Q: Why is silodosin given at night?

A: To avoid injury from dizziness or fainting, your doctor may advise you to take your first dose of silodosin with food at bedtime so that your body can adjust to its effects. The dosage is determined by your medical condition and response to treatment. Take this medication on a regular basis to get the most out of it.

Q: What is the mechanism of action of silodosin?

A: Silodosin helps relax the muscles in the prostate and in the opening to the bladder. This may help increase the flow of urine or decrease the symptoms. This medicine is usually given only to men.

Q: what are the side effects of silodosin?

A: Silodosin is a medication used to treat lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). It is a selective alpha-1 adrenergic receptor blocker that works by relaxing the muscles in the prostate gland and bladder. The most common side effects of silodosin are: Dizziness, lightheadedness, or fainting, especially when getting up suddenly from a sitting or lying position Ejaculation problems, such as decreased semen volume or retrograde ejaculation Diarrhea Stuffy or runny nose

References

Last Updated on: 04 Oct 2023 | 11:42 AM (IST)

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परिचय: “बिना मशरूम के खाना बिना बारिश के दिन जैसा होता है”। मशरूम या अगरिकस बिस्पोरस न तो सब्ज़ी है और न ही फल, बल्कि यह खाई जाने वाली एक फंगस है। बाजार में इसकी अलग-अलग किस्में (ताजा व सूखा) उपलब्ध हैं; जिसमे ओएस्टर , पोर्सिनी और बटन सबसे आम किस्में हैं। आमतौर पर, मशरूम

आंवला (Gooseberry in Hindi) के उपयोग, फ़ायदे और न्यूट्रिशनल वैल्यू

परिचय वानस्पतिक नाम एम्ब्लिका ऑफिसिनैलिस आमतौर पर आंवला को इंडियन गूजबेरी (भारतीय करौंदा) कहा जाता है। इन पेड़ों की बेरी को इनके औषधीय गुणों के कारण औषधीय फार्मूलेशन में प्रयुक्त किया जाता है। आंवला के पेड़ पर छोटी बेरीज़ होती हैं जो गोल और पीले-हरे रंग की होती है। इसके कई स्वास्थ्य फ़ायदों के कारण

केला (Banana in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: “एक दिन में एक केला (बनाना) खाने से मेरा एंडोर्फिन लेवल बना रहता है।” बनाना (मूसा प्रजाति) या केला एक लंबा, पीला फल है जो वास्तव में एक बेरी है। यह मुसासी (मुसासेई) परिवार से संबंधित हैं और इसमें मूसा एक्यूमिनाटा, मूसा बालबिसियाना आदि किस्में शामिल हैं। यह दक्षिणी एशिया के उष्णकटिबंधीय क्षेत्रों (ट्रॉपिकल

सौंफ (Fennel Seed in Hindi) : उपयोग, लाभ और न्यूट्रिशनल वैल्यू

परिचय: सौंफ (फेनल सीड) का वैज्ञानिक नाम फीनीकुलम वल्गारे है और यह एपोकिनेसी परिवार से संबंधित एक सुगंधित पौधा है।1 सौंफ (फेनल सीड) की एक अलग आकृति, आकार और रंग होता है; यह लंबी, पतली होती है और हल्के हरे या भूरे रंग की होती है। सौंफ (फेनल सीड) का पौधा इसके बीजों, पत्तियों और

ड्रैगन फ्रूट (Dragonfruit in Hindi): उपयोग, लाभ और न्यूट्रिशनल वैल्यू

ड्रैगन फ्रूट कैक्टस प्रजाति का फल होता है जिसके स्वास्थ्य से जुड़े कई लाभ होते हैं जैसे कि रक्त शर्करा (ब्लड शुगर) के जोखिम को कम करना, पाचन (डाइजेशन) में मदद करना आदि। यह एक ड्रैगन की तरह दिखता है और इस वजह से इसका यह नाम पड़ा। अब आप सोच रहे होंगे कि इस

तेजपत्ता (Bay Leaves in Hindi)– उपयोग, फायदे और न्यूट्रिशनल वैल्यू

परिचय तेजपत्ता सिनामोमम तमाला नामक पौधे की सूखी पत्तियां होती हैं। यह सिनामोमम वंश के लौरेसी परिवार का पौधा होता है जिसकी 270 प्रजातियां हैं और प्रमाणिक रूप से ये सभी एशिया और ऑस्ट्रेलिया में पाई जाती हैं। तेजपत्ता को भारतीय बे-लीफ़ भी कहा जाता है जो छोटे सदाबहार या बारहमासी वृक्ष पर होते हैं

नाशपाती (Pear in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू आदि!

परिचय: नाशपाती का वैज्ञानिक नाम पायरस कमिनिस एल है। यह रोज़ेसी फ़ैमिली से संबंधित है। नाशपाती को सेब के बाद सबसे ज्यादा पौष्टिक फल माना जाता है। यह विटामिन आहार फाइबर, एमिनो एसिड, एवं क्वेरसेटिन का बढ़िया स्रोत होता है। नाशपाती अपने मिठास, सुगंध, कुरकुरेपन और ख़ास खुशबू के लिए जाना जाता है। मूल रूप

सीए 125 टेस्ट (महिलाओं के लिए) (CA 125 Test (For Women) in Hindi): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: सीए 125 टेस्ट का इस्तेमाल शरीर में सीए 125 प्रोटीन के स्तर का पता लगाने के लिए किया जाता है, जो कैंसर का पता लगाने में मददगार साबित हो सकता है। नमूना प्रकार खून उपवास \ खाली पेट रहना जरूरी: नहीं उपनाम: कैंसर एंटीजन 125 टेस्ट, सीए-125 ट्यूमर मार्कर, सीए 125 ब्लड टेस्ट। सीए

सीरम इलेक्ट्रोलाइट्स (Serum Electrolytes): क्या है, खर्च, नॉर्मल रेंज, कैसे होता है, क्यों और कब

विवरण: एक सीरम इलेक्ट्रोलाइट परीक्षण आपके खून में मौजूद इलेक्ट्रोलाइट्स के स्तर को मापने की एक विधि है। इससे किडनी या दिल की समस्याओं जैसी कई बीमारियों का निदान करने में मदद मिल सकती है। आपको यह परीक्षण कितनी बार लेना चाहिए? कोई विशिष्ट आवृत्ति नहीं है। डॉक्टर आमतौर पर सीरम इलेक्ट्रोलाइट परीक्षण को मेटाबोलिक

हींग (Asafoetida in Hindi): उपयोग, फ़ायदे, न्यूट्रिशनल वैल्यू और अन्य बातें!

परिचय दुनिया के बहुत से हिस्सों में, हींग (ऐसाफ़ेटिडा) को खाने का स्वाद बढ़ाने वाले तत्व के रूप में और विभिन्न प्रकार की बीमारियों का पारंपरिक रूप से उपचार करने के लिए किया जाता है। हींग (फ़ेरुला ऐसाफ़ेटिडा), एक ओलिओ-गम-रेज़िन है जो अंबेलीफेरा फ़ैमिली के फ़ेरुला पौधों के तनों में बनती है। फ़ेरुला के पौधे

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