Perindopril

Molecule Description

Perindopril is an Angiotensin Converting Enzyme inhibitors (ACE inhibitors). It

is used for controlling high blood pressure. By lowering the blood pressure, it helps to reduce the risk of stroke and heart attack.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Perindopril

High blood pressure (hypertension)
Congestive Heart failure (a condition when the heart is unable to pump enough blood to meet the body's needs)
Prevents heart attack (a situation where the blood supply to the heart is reduced or blocked) and stroke
Preserves kidney function and retina in persons with diabetes
Reduce proteinuria in diabetic and non-diabetic renal disease
Scleroderma crisis

Contraindications of Perindopril

When should one not use Perindopril

Do not take it if you are allergic to Perindopril
Do not take this medicine in pregnancy (third trimester)
Do not take if severe skin rashes with previous ACE inhibitor treatment
Do not take if you have diabetes or impaired kidney function
Do not take if you are treated with a blood pressure lowering medicine containing Aliskiren

Side effects of Perindopril

Common side effects of this drug are:

Dry cough
Swelling of the face, tongue or throat (angioedema)
Taste disturbances
Low blood pressure (hypotension)
Increases Serum Potassium in the blood
Raised liver enzymes
Headache and dizziness
Breathing difficulty, wheezing
Kidney impairment

Precautions and Warnings of Perindopril

Pregnancy

Can I take Perindopril during pregnancy?

Perindopril is not recommended in early pregnancy and should not be taken in women more than three months pregnant, as it may cause serious harm to the unborn baby (fetus).

Breast Feeding

Can I take Perindopril while breastfeeding?

Perindopril is not recommended for breastfeeding mothers. However, no significant information is available.

Driving

Can I drive if I have consumed Perindopril?

This medicine may cause dizziness or fatigue due to low blood pressure in some persons. This may affect your driving ability. Do not drive unless you are feeling well.

Alcohol

Can I consume alcohol with Perindopril?

You should avoid or should take a limited amount of alcoholic beverages during this medication, however no significant information available.

Other General Warnings

Talk to your doctor if

You have kidney disease
Perindopril should be used with precaution in persons with kidney disease. Dose adjustment is needed in such patients.
If you have liver disease, inform your doctor if you develop any signs and symptoms of jaundice or have raised liver enzymes while taking this medicine. In such cases, dose adjustment of this medicine...
Read more

Mode of Action of Perindopril

How Does It Work?

Perindopril inhibits Angiotensin Converting Enzyme (ACE). So, it decreases the activity of the Renin Angiotensin Aldosterone System (RAAS) and prevent the conversion of Angiotensin I to Angiotensin II...

Interactions of Perindopril

Interactions with other medicines

Analgesics such as Ibuprofen, Indomethacin can risk kidney problem
Water pills (Diuretics) can lower down the blood pressure
Mood stabilizer (Lithium)
Immunosuppressant medicines such as Cyclosporine
Potassium supplements or medications that raise Serum Potassium such as Spironolactone, Amiloride

Interactions with food items

You should avoid potassium supplements as they interact with Perindopril causing an increased risk of side effects. Avoid alcohol along with this medicine. Avoid excess salt, packed food, pickles, etc...

Dietary Restrictions of Perindopril

No information is available on dietary restrictions while you are taking Perindopril, consult your doctor or pharmacist for further details.

Dosage of Perindopril

Overdose

Overdose of this medicine may cause sudden kidney failure, increased heart rate (tachycardia), low blood pressure (hypotension), dizziness, anxiety, and cough, increased levels of potassium in the blo...

Missed a Dose

If you missed a dose, take the next dose as soon as you remember. Do not take a double dose if you have missed the dose.

Content Details

WRITTEN BY

Dr. Arpit Verma

MBBS, MD CCEBDM Diabetology

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)

Q: What are the precautions to take before starting this treatment?

A: While taking Perindopril, particularly during the first month of its use, preferably, it should be taken at bed time as it causes dizziness. Women should inform their doctor if they are pregnant, planning a pregnancy or are nursing mothers. You should give a history of liver or kidney disease, if any.

Q: At what time should I take medicine?

A: At the start, you should try to take it during bedtime because it may cause dizziness for the first few days.

Q: Can you take potassium supplements along with this medicine?

A: This medicine may increase the level of potassium in blood. So you should avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.

References

View All

Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

Share This With Your Friends

Recent articles

See All

High Cholesterol Diet – Foods to Eat & Avoid!

Introduction Heart disease is the primary cause of deaths around the world. Having too much cholesterol can lead to severe cardiac issues. Thankfully, you can control and reduce the cholesterol levels by watching what you eat, i.e. the right cholesterol foods. Everything that you ingest has an impact on your cholesterol levels. Here is our

Your Ultimate Guide To A Balanced Diet For Diabetes

Introduction Type 2 Diabetes Mellitus is a chronic metabolic disorder affecting more than 100 million people in India. Diabetes occurs either due to insufficient insulin production, insulin resistance, or both which results in high levels of glucose in blood. Managing diabetes is crucial because uncontrolled diabetes can have serious complications like vision loss, kidney failure,

Benefits of Figs Soaked in Water Overnight: Exploring Nutritional Advantages

Key Highlights: Introduction Figs are versatile and scrumptious fruit that has been revered for its proposed nutritional benefits since ancient times. This little fruit, filled with a burst of sweetness, is a powerhouse of essential nutrients that may enhance your well-being. When soaked in water overnight, figs can make a valuable addition to your daily

Is Dry Ice Dangerous?

Introduction: Recently, dry ice has been in the news due to an unfortunate incident that occurred at a cafe in Gurugram, Haryana. Five diners unwittingly consumed dry ice, mistaking it for mouth freshener. As per news reports, the diners suffered serious injuries to their food pipe and oral cavity after accidentally ingesting the dry ice.

Bubonic Plague Reported: Are We In Danger?

Bubonic plague, which became notorious during the 14th Century in Europe and swept through India from the 1890s to 1910s, is caused by bacteria called Yersinia pestis. Contrary to popular belief, this plague isn’t caused by rat bites. The cause of bubonic plague is the bite of infected fleas. These fleas live in the hairs

Simple and Effective Skin Care Routine

Introduction Healthy skin is indicative of the quality of diet and lifestyle one follows. The largest organ of the human body and often overlooked, the skin acts as a barrier and prevents the external components from entering the inside of the body. This entails that, at times, it is exposed to critically harsh conditions, and

How to Save More on Heart Disease Medicines?

Introduction The heart is a vital organ of the body that literally keeps you alive. But several factors, such as lifestyle, comorbidities, and genetic predisposition, can put your heart health in jeopardy. Risk factors such as obesity, diabetes, high cholesterol, aging, and lack of exercise can increase the risk of cardiovascular disorders. An article published

JN.1: The New COVID Variant Strikes As The Year Draws To A Close

Introduction As we enter the festive finale of 2023, a renewed surge in COVID cases in India prompts people to follow COVID-appropriate behaviour. On December 8th, Kerala reported its first infection from the SARS-CoV variant, JN.1. Discovered earlier in the year in the United States and China, this JN.1 strain is now classified by the

How To Save More on Blood Pressure Medicines?

Introduction High blood pressure or hypertension has been on the rise in India! If not managed well, it can increase the risk of strokes, heart attacks and other heart conditions. In 2015-16, 19% of men and 17% of women had hypertension, but in 2019-2020, this number has gone up to 24% and 21%, respectively. Hypertension

Do Hot Showers Do More Harm Than Good?

Introduction The temperature of water you shower with matters more than you can fathom. While many people prefer hot water showers as they help them shake the laziness away, some also prefer cold showers as it makes them more alert and ready to take on the day. Especially in the winter, when one usually lacks

Disclaimer

The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner's medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.