Penicillin G
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Molecule Description
Penicillin G is an antibiotic and is used in treating different types of bacterial infections of the skin, ear, nose, throat, chest, bone, private parts, etc. It is also known as benzylpenicillin. It should be taken as directed by the physician, at the correct doses, and for the exact duration prescribed. Do not stop taking it abruptly, as it may result in treatment failure and recurrence of the infection; thus, you should always complete the course of the treatment. You may experience diarrhoea as the most common side effect after taking this medicine. However, not everyone experiences this side effect. Consult your doctor if diarrhoea persists or worsens. Before using, inform the doctor if you are pregnant, planning a pregnancy, or are breastfeeding, and about your detailed medical history.
Uses
Penicillin G is used to treat various types of bacterial infections such as skin infections, respiratory tract infections, dental infections, infection of tonsils and throat, lung infections, urinary tract infections, sexually transmitted infections, etc.
Contraindications
When should one not use Penicillin G
- If you are allergic to Benzylpenicillin or Penicillin G.
- If you have a history of an allergic reaction to other Penicillins or Cephalosporins.
Side effects
Common side effects of this drug are:
- Nausea
- Vomiting
- Diarrhoea
- Skin rashes
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have any problems with your liver or kidneys.
- You are suffering from any heart disease.
- You experience any severe allergic reaction or side effects after taking Penicillin G.
- You have diabetes.
- You are pregnant or think you might be pregnant.
- You are breastfeeding.
Mode of Action
How Does It Work?
Penicillin G works by inhibiting the enzymes called Penicillin-Binding Proteins (PBPs), which help to form a bacterial cell wall, thus causing bacteria's death and preventing the worsening of infection.
Interactions
Interactions with other medicines
- Penicillin G may interact with other medicines, discuss it with your doctor about all the medicines, supplements or herbal preparations you are taking. Also, you should inform your doctor if you have a planned surgery or any vaccination scheduled.
- The use of oral contraceptives along this medicine may alter its effects and may result in an unwanted pregnancy.
- Other medicines like probenecid, methotrexate, allopurinol, neomycin, warfarin should be used with caution along with this medicine.
- You should let the doctor or the laboratory person know that you are using this medicine while going for a lab test, as this medicine may interfere with the lab tests.
Dosage
Overdose
If you think you have taken too much, contact your doctor immediately or visit your nearest hospital.
Missed a Dose
If you have missed taking any dose of Penicillin G take it as soon as you remember it. However, if it's time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose of this medicine to compensate for the missed one.
Frequently Asked Questions (FAQs)
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References:
- Benzylpenicillin sodium 600mg Powder for Injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 9th Dec 2025]
- Benzylpenicillin sodium 600mg Powder for Injection - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 9th Dec 2025]
- PFIZERPEN Injection [Internet]. Cdn.pfizer.com. 2025 [cited 9th Dec 2025]
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