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Palbociclib

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Molecule Summary

Uses
Breast cancer
Therapy
Anti-Neoplastic
Side Effects
Hair loss, rash, vomiting, and diarrhoea
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Molecule Description

Palbociclib is used to treat certain types of breast cancer (oestrogen receptor-positive, human epidermal growth factor receptor 2-negative) that have spread to other organs. It is given alongside hormonal anticancer therapies. It should be taken with food, and you should try to take it at the same time every day to maximise its benefits. Your doctor will determine the necessary dose and frequency of administration based on your condition, which may change over time. You should take it exactly as prescribed by your doctor. Some common side effects of this medication include fatigue, hair loss, rash, vomiting, and diarrhoea. This medication may reduce the number of blood cells (decreasing red and white blood cells in your blood), thereby increasing susceptibility to infections. It is advisable to inform your doctor if you notice any symptoms of infection, such as fever, chills, weakness, bleeding, bruising, or nosebleeds. It may also cause dizziness; if this occurs, avoid driving or engaging in attention-demanding activities. Before taking it, inform your doctor if you have heart disease, liver, or kidney problems, or if you are taking any medications to treat infections. Many other medications can affect or be affected by this medicine, so inform your healthcare team about all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is essential to avoid pregnancy.

Uses

Palbociclib is used to treat certain types of breast cancer (oestrogen receptor-positive, human epidermal growth factor receptor 2-negative) that have spread to other organs.

Contraindications

When should one not use Palbociclib

  • If you are allergic to palbociclib or any of the other ingredients of this medicine.
  • If you are using preparations containing St. John's Wort.

Side effects

Common side effects of this drug are:

  • Stomatitis
  • Nausea
  • Diarrhoea
  • Vomiting
  • Rash
  • Alopecia
  • Dry skin
  • Fatigue
  • Asthenia
  • Fever
  • Neutropenia
  • Leukopenia
  • Anaemia
  • Thrombocytopenia

Precautions and Warnings

Pregnancy

Pregnancy

Palbociclib is not recommended during pregnancy and in women of childbearing potential not using contraception.

Breast Feeding

Breast Feeding

It is unknown if Palbociclib is excreted in human milk, so patients should not breast-feed while receiving this medication.

Driving

Driving

Palbociclib may lead to fatigue, and patients should exercise caution when driving or operating machinery.

Alcohol

Alcohol

Consult your doctor about alcohol consumption with Palbociclib.

Mode of Action

How Does It Work?

Palbociclib works by blocking certain proteins in the body known as CDK4 and CDK6, which play a crucial role in the growth and division of cancer cells. These proteins are part of a signalling chain within the cell that instructs it to multiply. By inhibiting these signals, palbociclib helps slow or halt the proliferation of cancer cells.

Dosage

Overdose

In the event of an overdose, please notify your doctor immediately and contact the nearest hospital.

Missed a Dose

If you miss a dose, an additional dose should not be taken that day. The next prescribed dose should be taken at the usual time.

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