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Osimertinib

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Molecule Summary

Uses
Non-small cell lung cancer
Therapy
Anti-Neoplastic
Side Effects
Low white blood cell counts, Low platelet counts, Diarrhoea, Dry skin, Decreased appetite, Stomatitis, Rash, Paronychia, Pruritus (itching on the skin)
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Molecule Description

Osimertinib is an anticancer medicine. It is used to treat metastatic non-small cell lung cancer (NSCLC). It is a prescription medicine and must be taken as advised by the doctor.

Uses

  • Non-small cell lung cancer

Contraindications

When should one not use Osimertinib

  • Allergy to osimertinib or any ingredients of this medicine
  • St. John's Wort should not be used together with this medicine

Side effects

Common side effects of this drug are:

  • Low white blood cell counts
  • Low platelet counts
  • Diarrhoea
  • Dry skin
  • Decreased appetite
  • Stomatitis
  • Rash
  • Paronychia
  • Pruritus (itching on the skin)

Precautions and Warnings

Pregnancy

Pregnancy

Osimertinib is contraindicated during pregnancy.

Breast Feeding

Breast Feeding

Osimertinib is contraindicated in breastfeeding females.

Driving

Driving

Osimertinib has no or negligible influence on the ability to drive and use machines.

Alcohol

Alcohol

No information is available on interactions of Osimertinib and alcohol. It is better to avoid alcohol.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have lung or breathing problems.
  • You have heart problems, including a condition called prolonged QTc
  • You have problems with your electrolytes, such as sodium, potassium, calcium or magnesium.
  • You have a history of eye problems.
  • You are pregnant or plan to become pregnant. Osimertinib can harm an unborn baby.
  • You are taking any other medications, including prescription and over-the-counter medicines, vitamins, or herbal supplements, especially heart or blood pressure-controlling medicines.
  • Inform your doctor right away if you become pregnant during treatment with Osimertinib.
  • Females who are able to become pregnant should use effective birth control during treatment with Osimertinib and for 6 weeks after the final dose.
  • Males who have female partners that can become pregnant should use effective birth control during treatment with Osimertinib and for 4 months after the final dose.
  • Do not breastfeed during treatment and for 2 weeks after your final dose.
  • Inform your doctor immediately if you develop a new fever or fever that does not go away, easy bruising or bleeding that will not stop, unusually pale skin, infection, tiredness, or weakness.

Mode of Action

How Does It Work?

Osimertinib is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI). It blocks the activity of EGFR, which controls the growth and division of cancer cells.

Dosage

Overdose

In the event of an overdose, report to your doctor immediately.

Missed a Dose

Report to your doctor immediately. Do not take extra doses to compensate for missed doses.

Frequently Asked Questions (FAQs)

Approximately 80% to 85% of lung cancers belong to non-small cell lung cancer NSCLC type.

An NSCLC (non-small cell lung cancer) has three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Although these subtypes originate from different lung cells, they are grouped together as NSCLC because they are often treated and have similar outlooks (prognosis). These are different from other types of lung cancer called small cell lung cancer.

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