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Orlistat

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Regulated

Molecule Description

Orlistat belongs to the class of medicines called gastrointestinal lipase inhibitors that are used to control obesity.

Uses

  • Used for obesity management: by aiding in weight loss
  • Reduce the risk of regaining weight which is already lost

Contraindications

When should one not use Orlistat

Do not take this medicine if you are suffering from malabsorption, allergic reaction to Orlistat or reduced gallbladder function.

Side effects

Common side effects of this drug are:

  • Oily or fatty stools
  • Oily spotting on undergarments
  • Gas and oily discharge from the bowel
  • Increased number of bowel movements
  • Stomach pain
  • Nausea
  • Rectal pain
  • Severe pain in lower back
  • Upper stomach pain
  • Itching
  • Tired feeling
  • Loss of appetite
  • Dark urine, clay-colored stools and jaundice (yellowing of the skin and eyes)

Precautions and Warnings

Pregnancy

Pregnancy

Tell your doctor if you are pregnant, planning a pregnancy. Do not take Orlistat if you are pregnant.

Breast Feeding

Breast Feeding

You must not breastfeed your infant during treatment with Orlistat as it is unknown whether this medicine passes into human milk.

Driving

Driving

No known effect on your ability to drive a vehicle.

Alcohol

Alcohol

No known interction. Consult with doctor while on this medication.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have diabetes
  • You have kidney disease. Use of Orlistat may be associated with kidney stones in patients suffering from chronic kidney disease

Mode of Action

How Does It Work?

It works in your digestive system by blocking nearly one-third of the fat in the food from being digested. Orlistat attaches to the enzymes in your digestive system (lipases) and prevents them from breaking down some of the fat you have eaten during your meal. The undigested fat cannot be absorbed and is removed by your body.

Interactions

Interactions with other medicines

  • Cyclosporine
  • Warfarin (blood-thinning medicine)
  • Amiodarone
  • Insulin or oral anti-diabetes medicine like Acarbose
  • Seizure medication (especially if your seizures get worse while taking orlistat)
  • Vitamin or mineral supplement that contains Beta Carotene or vitamin E
  • If you are taking any over-the-counter medicines or any other herbal medicines

Interactions with food items

  • It can be taken immediately before a meal, during a meal or up to one hour after a meal. No food interaction is reported.

Dietary Restrictions

No information is available on dietary restrictions while you are taking Orlistat, consult your doctor or pharmacist for further information.

Dosage

Overdose

The symptoms of an overdose of orlistat are not reported. They are presumably the same as the pronounced side effects, which include: nausea, vomiting, diarrhea, gas, abdominal distress, oily stools and incontinence of stools.

Missed a Dose

Take the missed dose as soon as you remember but no more than one hour after eating a meal. If it has been more than an hour since your last meal, skip the missed dose and take medicine at your next regularly scheduled time. Do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

This medicine must not be taken by children and adolescents under 18 years old.

Inform doctor:If you are taking a medicine for high blood pressure or high cholesterol or on thyroid medicine (Levothyroxine) as it may be necessary to adjust your doseIf you have any gastrointestinal problems or liver problemsIf you had any previous surgeries

Systemic absorption of Orlistat is minimal, however systemic absorption of the drug is not needed for activity.

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