Hydrochlorothiazide+Olmesartan Medoxomil

When should one not use Hydrochlorothiazide+Olmesartan Medoxomil

• If you are allergic to olmesartan, hydrochlorothiazide, or any other ingredient of Hydrochlorothiazide+Olmesartan Medoxomil.
• If you are allergic to other sulfonamide-derived medicines like sulfamethoxazole, sulfisoxazole. If you are not sure what these medicines are, please confirm with your doctor.
• If you have severe kidney disease or severe liver disease (yellowing of the skin and eyes, problems with drainage of the bile from the gallbladder).
• If you are more than 3 months pregnant.
• If you have low potassium levels, low sodium levels, high calcium levels, or high uric acid levels in your body.

Common side effects of this drug are:

• Headache
• Weakness
• Dizziness
• Chest pain
• Swelling of the legs, ankles, and hands

Other General Warnings

• You are taking medicines called aliskiren or ACE-inhibitors (enalapril, lisinopril, ramipril), especially for diabetes-related kidney problems.
• You have liver, kidney problems or if you have had a recent kidney transplant.

Other General Warnings

• You are taking high doses of a medicine called diuretics or if you are on a low salt diet.
• You have problems with your adrenal glands (primary aldosteronism), diabetes, asthma, allergies, or an autoimmune disease called lupus erythematosus.
• You have had skin cancer or if you develop an unexpected skin lesion during the treatment.
• You experienced breathing or lung problems (including inflammation or fluid in the lungs) after taking hydrochlorothiazide in the past.
• You develop diarrhoea that is severe, continues for a long time, and causes weight loss.
• You notice a decrease in vision or eye pain.
• You develop symptoms like thirst, dryness of the mouth, muscle pain or cramps, low blood pressure, feeling weak, sluggish, tired, sleepy or restless, nausea, vomiting, less need to pass urine.
• You are due to have tests for parathyroid function.
• You are pregnant, you plan on becoming pregnant soon, or become pregnant during the course of the medicine.

How Does It Work?

• Hydrochlorothiazide+Olmesartan Medoxomil contains two active substances that help to lower the blood pressure in individuals with high blood pressure - olmesartan and hydrochlorothiazide.
• Olmesartan works by blocking a substance in the body that causes the blood vessels to tighten. The tightening of the blood vessels restricts proper blood flow and causes the blood pressure to increase. When this substance is blocked, the blood vessels relax and blood flow occurs easily. As a result, the blood pressure is lowered.
• Hydrochlorothiazide helps the body to get rid of extra fluid by making your kidneys produce more urine. This leads to a reduction in the blood pressure.

Interactions with other medicines

• Some medicines can affect the way Hydrochlorothiazide+Olmesartan Medoxomil works, or Hydrochlorothiazide+Olmesartan Medoxomil itself can reduce the effectiveness of other medicines taken at the same time.
• Tell your doctor about all medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
• Hydrochlorothiazide+Olmesartan Medoxomil should not be used along with medicines containing lithium, ACE-inhibitors (captopril, enalapril, lisinopril, benazepril, fosinopril), angiotensin II receptor blockers (azilsartan, fimasartan), aliskiren, medicines affecting potassium levels (potassium-sparing diuretics like spironolactone, potassium supplements, salt substitutes containing potassium, other medicinal products that may increase potassium levels like heparin), and bile acid sequestering agent colesevelam.
• Especially if you are taking medicines to treat high blood pressure, heart failure, abnormal heart rhythm, abnormal cholesterol levels, skeletal muscle relaxants, blood thinners, anti-infectives, anti-diabetics, anti-asthmatics, pain killers, immunomodulatory medicines or medicines for brain-related disorders.

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