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Noscapine

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Molecule Summary

Uses
Short term treatment of dry cough
Therapy
Cough Cold Preparation
Side Effects
Nausea, vomiting, increased heart rate, loss of appetite, dilated pupils, decreased coordination, drowsiness
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Molecule Description

Noscapine is a medication that primarily aids in the treatment of cough.

Uses

  • Treatment of dry (non-productive) cough

Contraindications

When should one not use Noscapine

  • If you are hypersensitive to noscapine or other ingredients of this medicine.
  • If you are pregnant.
  • If you have been diagnosed with high blood pressure.
  • If you have a history of alcoholism.
  • If you suffer from liver dysfunction.
  • If you have been diagnosed with peptic ulcer disease.
  • If you have had a cardiac arrest.
  • If you have been diagnosed with thyroid disorders.

Side effects

Common side effects of this drug are:

  • Nausea and vomiting
  • Increased heart rate
  • Loss of appetite
  • Dilated pupils
  • Decreased coordination
  • Drowsiness

Precautions and Warnings

Pregnancy

Pregnancy

Noscapine is considered unsafe during pregnancy and is contraindicated.

Breast Feeding

Breast Feeding

Consult your doctor before taking Noscapine while breastfeeding.

Driving

Driving

Common side effects of using Noscapine include reduced coordination, drowsiness and muscle spasms. Hence, driving and use of heavy machinery are not recommended.

Alcohol

Alcohol

No. Consuming alcohol and other CNS depressants while using Noscapine can result in a higher incidence of undesirable effects like sedation. It can even cause respiratory depression and coma.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You experience persistent or worsening side effects.
  • Your condition does not improve.
  • You conceive or are planning a pregnancy during the course of the medication.
  • You are taking any herbal medicines or supplements.

Mode of Action

How Does It Work?

Noscapine works on the brain by action on particular receptors called sigma receptors. Studies in animal subjects have shown that by activating this receptor, it produces cough-suppressing (antitussive) effects.

Interactions

Interactions with other medicines

  • The use of Noscapine along with alcohol and other CNS depressants is contraindicated.
  • The concurrent use of noscapine with a group of medications called MAOIs (monoamine oxidase inhibitors) is contraindicated.
  • It should not be used alongside medications that prevent clotting of blood like warfarin, as it can increase this effect. This can result in bleeding problems.

Interactions with food items

  • Noscapine is recommended to be taken before food on an empty stomach.
  • Drink plenty of fluids.
  • Avoid consuming grapefruit or its juice while taking this medicine, as it may cause unwanted effects by decreasing the metabolisation of noscapine.

Dosage

Overdose

Effects of Noscapine overdose are similar to that of alcohol intoxication. They can present with mild sedation, poor coordination, slurring of speech, difficulty in walking/balancing, vomiting, insomnia. Overdoses with very high quantities of this medicine can be life-threatening. In case of a suspected overdose, immediately rush the patient to the nearest tertiary care hospital for emergency management.

Missed a Dose

If you miss a dose of Noscapine, it is advised to take it as soon as possible. If it is almost time for the next dose, it is recommended to skip the missed dose and go back to the regular schedule. Do not double the dose of the medicine.

Frequently Asked Questions (FAQs)

Noscapine is indicated only for dry/non-productive cough. It is not helpful in decreasing phlegm production. Consult your doctor for medications more suited to your needs.

Consult your doctor to reach a diagnosis. Treatment may involve additional medication, and delay in diagnosis may be harmful. Do not use Noscapine without seeking medical consultation.

If your symptoms do not improve after a week's use of Noscapine, inform your treating physician. They may need to investigate further to determine the cause of your cough to prescribe appropriate treatment. Do not increase the dose/double the medicine without your physician's directions.

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