Nitrofurantoin
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Molecule Description
Nitrofurantoin is an antibiotic medicine. It is primarily used to treat and prevent common urinary tract infections (UTIs), especially those affecting the bladder. It has a targeted action: it is filtered into the urine, where it reaches high concentrations directly at the infection site. This minimizes its effect on "good" bacteria elsewhere in your body, like your gut. The molecule works by interfering with the bacteria's key processes, preventing them from growing and multiplying, essentially killing the germs that cause the infection. You must finish the entire course of medicine, even if your symptoms disappear, to ensure the infection is completely cleared and prevent the bacteria from becoming resistant to the medicine. Common side effects include headache and harmlessly dark yellow or brown urine. Food significantly increases it's absorption and helps reduce common side effects like nausea, vomiting, and stomach upset.
Uses
Nitrofurantoin is used for treatment, prevention and long-term suppression of uncomplicated urinary tract infections.
Contraindications
When should one not use Nitrofurantoin
- Allergy to Nitrofurantoin, other medicines containing Nitrofurantoin.
- Kidney disease (moderate to severe)
- A blood disorder in which there is over-accumulation of blood forming proteins (porphyria)
- A blood disorder that causes break-down of red blood cells (G6PD - Glucose-6-Phosphate Dehydrogenase deficiency)
- Infants under three months of age
Side effects
Common side effects of this drug are:
- Headache
- Nausea, vomiting
- Stomach pain, reduced hunger, loose stools
- Feeling dizzy, drowsiness
- Damage to red blood cells – easy bruising, delayed clotting, low blood counts, fever, sore throat
- Nervous system disorders – changes of mood, confusion, weakness, blurred vision
- Skin rashes, reddened skin (due to damage of small blood vessels), blisters with or without rapid heart rate
- Pain in the face, stomach and joints (due to reactive salivary glands, pancreas)
- Liver and kidney disorders
- Urinary tract infections (by bacteria that are not killed by Nitrofurantoin)
- Loss of hair
- Collapse/ loss of consciousness, lung problems – fever, chills, cough, fast breathing
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have diabetes
- You have low red blood count or Vitamin B12 deficiency
- You have any disease that may cause severe weakness
- You have any diseases of the lungs or the nervous system
- You have a history of allergic reactions
- You pass dark coloured urine
- You experience any symptoms of liver disease - fatigue, yellow eyes (jaundice), joint pains, stomach discomfort, vomiting, reduced hunger and pale/ grey coloured stools
Mode of Action
How Does It Work?
Nitrofurantoin kills the bacteria by entering their cells and damaging their genetic material (DNA) in the urinary bladder, kidney and other parts of the urinary tract.
Interactions
Interactions with other medicines
- Medicines used for indigestion (antacids – Magnesium Trisilicate, etc.)
- Medicines used for gout (Probenecid, Sufinpyrazone, etc.)
- Medicines used to treat raised pressure in the eyes (glaucoma-Acetazolamide, etc.)
- Medicines used to reduce acidity of urine (Potassium Citrate)
- Medicines used to treat certain infections (Quinolones-Ciprofloxacin, Norfloxacin, etc.)
- Typhoid vaccine
Interactions with food items
Nitrofurantoin must be taken with food – meals or milk. This will cause the medicine to be better absorbed and reduces side effects.
Dietary Restrictions
No information is available on dietary restrictions while you are taking this medicine, consult your doctor or pharmacist for further information.
Dosage
Overdose
Accidental overdose of Nitrofurantoin may irritate the stomach, nausea or vomiting. Medical attention may be necessary in case of high overdose. Inform your doctor if you experience any new symptoms.
Missed a Dose
It depends on your condition and dosage. In some situations, Nitrofurantoin may be prescribed once a day and in some others, 2-4 times a day. Check the time interval specified by your doctor between 2 doses. If it is once a day, you can take the missed dose as soon as you remember. If it is 2-4 times a day, you may skip the missed dose and continue with the next dose. Do not take a double dose to make up for a forgotten dosage. If you are not sure, ask your doctor or pharmacist.
Frequently Asked Questions (FAQs)
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