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Nalbuphine

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Molecule Summary

Uses
moderate to severe pain
Therapy
Analgesic For Severe Pain
Side Effects
nausea, vomiting, drowsiness, dizziness, constipation, headache, sweating, slow or shallow breathing, dry mouth, loss of consciousness.
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Molecule Description

Nalbuphine is indicated for managing moderate to severe pain. It belongs to the class of medicine called opioid analgesics or narcotics. It is prescribed for relieving pain when it can not be managed by oral medicines. It can be used to address localised or general pain.

Uses

  • As per CDSCO, Nalbuphine is used for:
  • Managing moderate to severe pain.

Contraindications

When should one not use Nalbuphine

If you are allergic to any component of this medication.

Precautions and Warnings

Pregnancy

Pregnancy

Yes, Nalbuphine is usually considered safe to use in pregnant women. There are limited human studies. However, animal studies have shown little to no side effects to the unborn baby. It is not recommended for pregnant women who are in labour.

Breast Feeding

Breast Feeding

Yes, Nalbuphine can be safe to use during breastfeeding. There is some human data suggesting that this medicine passes into the milk, however, it does not pose any serious risk to the baby.

Driving

Driving

No, do not drive after taking Nalbuphine. It causes side effects like lightheadedness, drowsiness, and blurred vision. Therefore, this medicine affects your ability to drive.

Alcohol

Alcohol

No, it is not advised to consume alcohol with Nalbuphine. It exaggerates the effects of alcohol. It can cause side effects like drowsiness, nausea, vomiting, unconsciousness, dizziness, etc.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You have a seizure disorder and are under treatment for it.
  • You consume alcohol every day.
  • You suffer from serious malnutrition, use this medication with caution after informing your doctor.
  • You have a serious liver or kidney disease. The dose of this medication will need adjustment.
  • You are using any ayurvedic or herbal products or supplements.
  • You are an elderly person over 65 years of age. Be cautious as it stays in the body for long and causes serious side effects.

Mode of Action

How Does It Work?

Nalbuphine is an opioid pain reliever. It acts centrally and inhibits the transmission of pain signals from nerves in the brain to the rest of the body. It works by binding certain receptors, which blocks the pain pathways in the nervous system. It increases the production of norepinephrine and serotonin, the chemical messengers responsible for reducing pain and inducing a calming effect in the body.

Interactions

Interactions with other medicines

  • Do not take Nalbuphine with other opioid pain medications, as they can cause serious adverse effects.
  • Do not take Nalbuphine with medicines like linezolid, naltrexone, methylene blue, etc. They can cause increased side effects like drowsiness, dizziness, lack of energy, sudden muscle movements, vomitings, etc.
  • Try not to take Nalbuphine with antihistamines (allergy medicine), like cetirizine and diphenhydramine, sleeping pills, muscle relaxants, cold or cough medicine, etc., as they can increase the effect of drowsiness.

Interactions with food items

  • Nalbuphine does not have any adverse interactions with food. It can be taken before or after consuming a meal. If you have any stomach problems, take this medicine after having food.
  • If you have constipation while using this medicine, eat food with more fibre.

Dosage

Overdose

  • Nalbuphine overdose can cause abdominal pain, dizziness, fainting, vomiting, seizures, low blood sugar, sweating, cardiac arrest, lethargy, low blood pressure, yellow skin, confusion, and coma. In case of Nalbuphine overdose, seek immediate medical treatment from the nearest medical centre.

Missed a Dose

Nalbuphine is administered in a hospital/clinical setting or at home. If you are going to the hospital, try to go for every dose and follow all the instructions given by your doctor. If you have missed a dose, call your doctor and set up a new appointment as soon as possible. If you missed the dose at home, do not take the missed dose if it's already time for the next one. Do not take two doses at the same time or close together, as it can lead to an overdose.

Frequently Asked Questions (FAQs)

Nalbuphine is only recommended as a short-term treatment for relieving pain. You can stop using it once the pain has reduced. However, if you have any concerns about when to stop taking the medicine, please consult your doctor.

Most cold and allergy medicines can cause drowsiness and slow breathing. When combined with Nalbuphine, these side effects can get exaggerated. It is advised to take these medications only after consulting your doctor.

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