Nalbuphine
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Molecule Summary
| Uses | moderate to severe pain |
| Therapy | Analgesic For Severe Pain |
| Side Effects | nausea, vomiting, drowsiness, dizziness, constipation, headache, sweating, slow or shallow breathing, dry mouth, loss of consciousness. |
Medicines
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19k pincodes
Molecule Description
Nalbuphine is indicated for managing moderate to severe pain. It belongs to the class of medicine called opioid analgesics or narcotics. It is prescribed for relieving pain when it can not be managed by oral medicines. It can be used to address localised or general pain.
Uses
- As per CDSCO, Nalbuphine is used for:
- Managing moderate to severe pain.
Contraindications
When should one not use Nalbuphine
If you are allergic to any component of this medication.
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have a seizure disorder and are under treatment for it.
- You consume alcohol every day.
- You suffer from serious malnutrition, use this medication with caution after informing your doctor.
- You have a serious liver or kidney disease. The dose of this medication will need adjustment.
- You are using any ayurvedic or herbal products or supplements.
- You are an elderly person over 65 years of age. Be cautious as it stays in the body for long and causes serious side effects.
Mode of Action
How Does It Work?
Nalbuphine is an opioid pain reliever. It acts centrally and inhibits the transmission of pain signals from nerves in the brain to the rest of the body. It works by binding certain receptors, which blocks the pain pathways in the nervous system. It increases the production of norepinephrine and serotonin, the chemical messengers responsible for reducing pain and inducing a calming effect in the body.
Interactions
Interactions with other medicines
- Do not take Nalbuphine with other opioid pain medications, as they can cause serious adverse effects.
- Do not take Nalbuphine with medicines like linezolid, naltrexone, methylene blue, etc. They can cause increased side effects like drowsiness, dizziness, lack of energy, sudden muscle movements, vomitings, etc.
- Try not to take Nalbuphine with antihistamines (allergy medicine), like cetirizine and diphenhydramine, sleeping pills, muscle relaxants, cold or cough medicine, etc., as they can increase the effect of drowsiness.
Interactions with food items
- Nalbuphine does not have any adverse interactions with food. It can be taken before or after consuming a meal. If you have any stomach problems, take this medicine after having food.
- If you have constipation while using this medicine, eat food with more fibre.
Dosage
Overdose
- Nalbuphine overdose can cause abdominal pain, dizziness, fainting, vomiting, seizures, low blood sugar, sweating, cardiac arrest, lethargy, low blood pressure, yellow skin, confusion, and coma. In case of Nalbuphine overdose, seek immediate medical treatment from the nearest medical centre.
Missed a Dose
Nalbuphine is administered in a hospital/clinical setting or at home. If you are going to the hospital, try to go for every dose and follow all the instructions given by your doctor. If you have missed a dose, call your doctor and set up a new appointment as soon as possible. If you missed the dose at home, do not take the missed dose if it's already time for the next one. Do not take two doses at the same time or close together, as it can lead to an overdose.
Frequently Asked Questions (FAQs)
Articles
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References:
- Nalbuphine Injection: Medlineplus Drug Information [Internet]. MedlinePlus. U.S. National Library of Medicine; [cited 2026 Jun 9]. Available from:
- Nalbuphine [Internet]. National Center for Biotechnology Information. PubChem Compound Database. U.S. National Library of Medicine; [cited 2026 Jun 9]. Available from:
- Jaillon P;Gardin ME;Lecocq B;Richard MO;Meignan S;Blondel Y;Grippat JC;Bergnieres J;Vergnoux O; Pharmacokinetics of nalbuphine in infants, young healthy volunteers, and elderly patients [Internet]. Clinical pharmacology and therapeutics. U.S. National Library of Medicine; [cited 2026 Jun 9]. Available from:
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