Moclobemide

Uses	Depression
Therapy	Anti-Depressant
Side Effects	Headache, Nausea, Vomiting, Dry Mouth, Confusion, Drowsiness, Insomnia

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Molecule Description

Moclobemide is a prescription medication that is used for the management of Depression and Social Phobia. Depression is a mental disorder characterised by episodes of sadness, mood swings, loss of interest, hopelessness etc. Social phobia is anxiety characterised by episodes of fear, worry, and nervousness in social situations.

Uses

As per CDSCO, Moclobemide is used for:
Management of Depression

Contraindications

When should one not use Moclobemide

If you are allergic to moclobemide or any other ingredient of this medicine.
If you are already using other antidepressants or anti-anxiety or sedative medications.
If you have an adrenal gland tumour.
If you are pregnant or lactating.

Side effects

Common side effects of this drug are:

Headache
Nausea
Vomiting
Dry Mouth
Confusion
Drowsiness
Insomnia

Precautions and Warnings

Pregnancy

Moclobemide is not recommended during pregnancy. Some research studies have shown harmful effects of the medicines on the developing baby. Pregnant women are advised to take Moclobemide only if their doctor recommends it.

Breast Feeding

Moclobemide is not recommended for breastfeeding mothers. Studies show it gets excreted into breast milk and can harm the baby. Discuss the potential risks and benefits of taking this medicine with your doctor.

Driving

Moclobemide may cause side effects that could affect your ability to drive. This medicine may cause dizziness, lethargy and lightheadedness. Do not drive if you are experiencing these side effects after taking Moclobemide.

Alcohol

Avoid Alcohol consumption with Moclobemide. It increases the severity of side effects like drowsiness, dizziness, blurred vision, lethargy etc. It also worsens the condition of the disease for which you are taking this medicine.

Other General Warnings

Talk to your doctor if

You have any allergic reactions to Moclobemide.
You are taking other prescription medications, herbal products, vitamins and nutritional supplements you are taking or planning to take as there is a chance of Drug Interaction.
You experience any self-harming thoughts or suicidal ideation.
You notice sudden vision changes.
You experience severe side effects persistently.
You have a history of mild or severe liver and kidney disease; this medicine may need a dose adjustment.
You have a thyroid disorder or a heart condition.
You have lactose intolerance.
You are pregnant or planning a pregnancy during the course of this medicine.
You are using any ayurvedic/ herbal medicines, vitamins, and other health supplements.

Mode of Action

How Does It Work?

Moclobemide works by blocking the action of a chemical substance known as monoamine oxidase A (MAO-A) in the nervous system.

Interactions

Interactions with other medicines

Antidepressants like venlafaxine, fluoxetine, fluvoxamine, clomipramine, citalopram, escitalopram, lithium, triptans, buspirone, amphetamines, tramadol, and tryptophan are strictly contraindicated with Moclobemide as they may cause serotonin syndrome.
Moclobemide should not be given with antiarrhythmics, cisapride, macrolide antibiotics, antihistamines, or certain diuretics as they affect the metabolism of Moclobemide, leading to side effects.
Moclobemide interaction with NSAIDs, Aspirin, and other medications which affect coagulation may increase the risk of bleeding and bruising.

Interactions with food items

You should avoid consuming foods that are high in tyramine, such as aged cheese, cured meats, yeast-extract spreads and soy products. Moclobemide may also interact with Herbal supplements like St. John's Wort and can lead to severe side effects.

Dosage

Overdose

Overdose of Moclobemide can result in nausea, extreme drowsiness, high blood pressure, agitation, confusion, decreased reflexes, loss of memory, convulsions (seizures) etc. If you experience any of these overdose symptoms, immediately seek emergency medical treatment from a nearby hospital.

Missed a Dose

If you've missed a dose of Moclobemide, take it as soon as you remember. If it's already time to take the next scheduled dose, take the next scheduled dose and skip the missed one. Do not double doses as it can cause overdose side effects. Talk to your doctor if you keep missing the dose regularly.

Frequently Asked Questions (FAQs)

Yes, there are medications from more than 20 antidepressants classes available. Although all antidepressants classes of medicine have broadly similar therapeutic effects, they differ in the side effects they produce. Psychological therapies like CBT (cognitive behavioural therapy) can also help in some types of depression, either as an alternative to medication or alongside it.

Moclobemide is to be taken until you see an improvement in your health conditions. However, It usually takes between 4 to 6 weeks before you see improvement in your symptoms. Once you're feeling better, you are advised to take this medicine for several more months to prevent the symptoms from returning.

Yes, suddenly stopping the consumption of Moclobemide causes withdrawal symptoms, including agitation, nausea, tremor, confusion, diarrhoea, vomiting, and sweating. Consult your doctor before stopping the consumption of Moclobemide, as doses need to be tapered slowly to avoid unwanted side effects.

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