Loxapine

Uses	Schizophrenia, Manic depression (bipolar disorder)
Therapy	Anti-Psychotics
Side Effects	Parkinson's, difficulty sleeping, sleepiness, depression, anxiety, restlessness, shortness of breath, abdominal pain, dizziness, and headache

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Molecule Description

Loxapine is an antipsychotic medication used to treat schizophrenia and manic depression (or bipolar disorder).

Uses

Treatment of Schizophrenia
Treatment of Manic depression (bipolar disorder)

Contraindications

When should one not use Loxapine

If you have severe central nervous system disorders: Due to the increased risk of the patient's condition worsening, this medicine is not advised for use in patients with severe central nervous system depression, coma, or uncontrolled seizure disorder.
If you have a known allergy to loxapine or any of the other ingredients in this medicine.
If you have Dementia-related psychosis: Because of the increased risk of death, Loxapine is not recommended for individuals with dementia-related psychosis.
If you develop Neuroleptic Malignant Syndrome. It is characterised by an increase in body temperature, muscle rigidity, and altered consciousness. Loxapine should be stopped promptly.

Side effects

Common side effects of this drug are:

Dizziness
Faintness
Blurred vision
Weakness
Dry mouth
Difficulty falling or staying asleep

Precautions and Warnings

Pregnancy

If you're pregnant, avoid taking Loxapine unless your doctor tells you to. If you have any concerns, please consult your doctor; your doctor will only prescribe if the benefits outweigh the risks.

Breast Feeding

Because Loxapine can transfer into breast milk, breastfeeding is not recommended while using this medication. Before using Loxapine, see your doctor; your doctor will determine whether or not breastfeeding moms can take Loxapine. If your infant shows symptoms of dizziness or tremor, tell your doctor.

Driving

Loxapine might make you sleepy and dizzy by lowering your alertness or affecting your vision. If you experience any of these symptoms after taking Loxapine, you should not drive.

Alcohol

Alcohol should be avoided when taking Loxapine because it can cause drowsiness and drop blood pressure.

Other General Warnings

Talk to your doctor if

You experience symptoms like involuntary tongue, lip, and cheek movements. Any such symptoms should be reported to your doctor right away. Depending on the clinical situation, a gradual dose decrease or withdrawal of the medicine may be indicated.
You experience seizures: Because of the increased risk of recurrent seizures, Loxapine should be used with caution in individuals with a known history of seizure disease. Appropriate remedial actions, dose changes, or substitution with a suitable alternative may be required depending on the clinical situation.

Mode of Action

How Does It Work?

Loxapine is a dopamine antagonist and a 5-HT2 blocker for serotonin (chemical messengers). Loxapine is a tranquiliser, and its specific mechanism of action is unknown. Nevertheless, it is thought that through antagonising dopamine and serotonin receptors, a strong cortical inhibition occurs, resulting in tranquillisation and aggressiveness suppression.

Interactions

Interactions with other medicines

Medicines used to treat schizophrenia and bipolar disorder (aripiprazole)
Medicines used to treat Anxiety disorders (lorazepam, diazepam, alprazolam)
Anti depression (citalopram, duloxetine, fluoxetine, escitalopram, trazodone, sertraline)
Anti Allergic (diphenhydramine, hydroxyzine)
Medicine used to treat Mania (divalproex sodium)
Fits treating medicines (gabapentin, clonazepam, lamotrigine, pregabalin)
Painkillers (fentanyl, oxycodone, tramadol)
Asthma medication (albuterol)
Antipsychotics (quetiapine, clozapine)
Anti Parkinson's medicine (zonisamide)
Loxapine may interact with some medicines and result in CNS depression. It increases the risk of hypotension and other worsening side effects.

Dosage

Overdose

Overdosing can result from mild CNS and cardiovascular system depression to significant hypotension, respiratory depression, and coma, as expected given the medication's pharmacologic activities. It's important to be aware of the risk of extrapyramidal symptoms and/or convulsive seizures.

Missed a Dose

If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose. Otherwise, take the missed dose as soon as you remember.

Frequently Asked Questions (FAQs)

Oral administration after food is recommended for this medication. It may cause stomach distress if taken on an empty stomach. Please seek medical advice before using Loxapine.

The time it takes to notice an effect varies from person to person. Please discuss how long you'll need to take Loxapine with your doctor.

Administration of Loxapine should be done as prescribed by the doctor. Since this medication can interact with other medications and may have severe side effects, it is recommended to consult a doctor for dosage and duration.

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References:

Loxapine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 11 June 2026].

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