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Molecule Description

Lisinopril is an ACE inhibitor (ACE stands for Angiotensin Converting Enzyme).

Uses of Lisinopril

  • To treat high blood pressure (hypertension)
  • To treat heart failure (congestive heart failure)

Contraindications of Lisinopril

When should one not use Lisinopril

  • Do not take this medicine if you have any allergy to Lisinopril or other ACE inhibitors such as Captopril if you have diabetes
  • Also, this medicine is not be used in patients who are taking blood lowering medication containing Aliskiren and medicines used to treat long-time heart failure like Valsartan

Side effects of Lisinopril

Common side effects of this drug are:

  • Allergic reaction such as difficulty in breathing, swelling tongue or difficulty in swallowing
  • Increased in liver enzymes
  • Yellowing of skin or eye (jaundice)
  • Low blood pressure
  • Dizziness

Precautions and Warnings of Lisinopril


Can I take Lisinopril during pregnancy?
Do not use Lisinopril if you are pregnant. If you are pregnant, stop taking this medicine and tell your doctor immediately. This medicine can cause injury or even death of the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking Lisinopril.

Breast Feeding

Can I take Lisinopril while breastfeeding?
Not much information is available on the use of Lisinopril during breastfeeding. Hence Lisinopril is not recommended for mothers who are breastfeeding. An alternate medicine may be preferred, especially while nursing a newborn or preterm infant.


Can I drive if I have consumed Lisinopril?
While taking Lisinopril, you may feel dizzy or tired. If this happens, do not drive.


Can I consume alcohol with Lisinopril?
Alcohol can also lower your blood pressure and may increase the risk of specific side effects. Avoid alcohol.

Other General Warnings

Talk to your doctor if
  • You have low blood pressure (hypotension)
  • You are dehydrated due to treatment with Diuretic medicine
  • You suffer from abnormal functioning of the heart
  • You have had a stroke or mini-stroke (also known as Transient Ischaemic Attack (TIA))
  • You suffer from kidney disease, improper functioning of the kidneys or narrowing (stenosis) of the blood vessels to the kidney
  • You have diabetes
  • You have high potassium level in your blood (hyperkalaemia)

Mode of Action of Lisinopril

How Does It Work?

ACE inhibitors block the enzyme called Angiotensin Converting Enzyme and thereby lowers the blood pressure by widening the blood vessels. This allows the blood to flow more efficiently and reduces the effort needed to pump blood around the body.
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Interactions of Lisinopril

Interactions with other medicines

Lisinopril may interact with medicines such as Aspirin, Aliskiren, Non-Steroidal Anti-Inflammatory Drugs like Ibuprofen and Indomethacin, Diuretics like Furosemide, Torsemide and antidepressants.

Interactions with food items

If you are on treatment with Lisinopril, then avoid supplements containing potassium as they interact with it and increase the risk of side effects.

Dietary Restrictions of Lisinopril

No information is available on dietary restrictions while you are taking Lisinopril, consult your doctor or pharmacist for further information.

Dosage of Lisinopril


Symptoms of overdose include low blood pressure, shock (a dangerous decrease of blood pressure which if untreated, may lead to collapse or loss of consciousness), kidney failure, changes in blood salts which may be seen in blood tests, difficulty in breathing, increased or decreased heartbeat, dizziness, anxiety and cough. Consult doctor immediately if you suspect overdose.
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Missed a Dose

Take the missed dose as early as you remember. If it is almost the time for your next dose, skip the missed dose. Do not take extra medicine to compensate for the missed dose.

Content Details


Dr. Rukman Mecca

MBBS, MD (Community Medicine)


Dr. Ritu Budania

MBBS, MD (Pharmacology)

Frequently Asked Questions (FAQs)


Q: Why should we not take potassium-rich foods or potassium supplements while taking this medicine?

A: Lisinopril is known to cause Hyperkalemia, a condition where there is an increase in potassium levels, hence potassium-rich foods or potassium supplements are avoided while taking this medicine.

Q: Lisinopril is avoided in which kidney conditions?

A: If you suffer from kidney disease or improper functioning of the kidneys. If you suffer from narrowing (stenosis) of the blood vessels to the kidneys.
Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts. Please click here for detailed T&C.
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