Lisinopril

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Molecule Description

Lisinopril is an ACE inhibitor (ACE stands for Angiotensin Converting Enzyme).

Uses

To treat high blood pressure (hypertension)
To treat heart failure (congestive heart failure)

Contraindications

When should one not use Lisinopril

Do not take this medicine if you have any allergy to Lisinopril or other ACE inhibitors such as Captopril if you have diabetes
Also, this medicine is not be used in patients who are taking blood lowering medication containing Aliskiren and medicines used to treat long-time heart failure like Valsartan

Side effects

Common side effects of this drug are:

Allergic reaction such as difficulty in breathing, swelling tongue or difficulty in swallowing
Increased in liver enzymes
Yellowing of skin or eye (jaundice)
Low blood pressure
Dizziness

Precautions and Warnings

Pregnancy

Do not use Lisinopril if you are pregnant. If you are pregnant, stop taking this medicine and tell your doctor immediately. This medicine can cause injury or even death of the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking Lisinopril.

Breast Feeding

Not much information is available on the use of Lisinopril during breastfeeding. Hence Lisinopril is not recommended for mothers who are breastfeeding. An alternate medicine may be preferred, especially while nursing a newborn or preterm infant.

Driving

While taking Lisinopril, you may feel dizzy or tired. If this happens, do not drive.

Alcohol

Alcohol can also lower your blood pressure and may increase the risk of specific side effects. Avoid alcohol.

Other General Warnings

Talk to your doctor if

You have low blood pressure (hypotension)
You are dehydrated due to treatment with Diuretic medicine
You suffer from abnormal functioning of the heart
You have had a stroke or mini-stroke (also known as Transient Ischaemic Attack (TIA))
You suffer from kidney disease, improper functioning of the kidneys or narrowing (stenosis) of the blood vessels to the kidney
You have diabetes
You have high potassium level in your blood (hyperkalaemia)

Mode of Action

How Does It Work?

ACE inhibitors block the enzyme called Angiotensin Converting Enzyme and thereby lowers the blood pressure by widening the blood vessels. This allows the blood to flow more efficiently and reduces the effort needed to pump blood around the body.

Interactions

Interactions with other medicines

Lisinopril may interact with medicines such as Aspirin, Aliskiren, Non-Steroidal Anti-Inflammatory Drugs like Ibuprofen and Indomethacin, Diuretics like Furosemide, Torsemide and antidepressants.

Interactions with food items

If you are on treatment with Lisinopril, then avoid supplements containing potassium as they interact with it and increase the risk of side effects.

Dietary Restrictions

No information is available on dietary restrictions while you are taking Lisinopril, consult your doctor or pharmacist for further information.

Dosage

Overdose

Symptoms of overdose include low blood pressure, shock (a dangerous decrease of blood pressure which if untreated, may lead to collapse or loss of consciousness), kidney failure, changes in blood salts which may be seen in blood tests, difficulty in breathing, increased or decreased heartbeat, dizziness, anxiety and cough. Consult doctor immediately if you suspect overdose.

Missed a Dose

Take the missed dose as early as you remember. If it is almost the time for your next dose, skip the missed dose. Do not take extra medicine to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Lisinopril is known to cause Hyperkalemia, a condition where there is an increase in potassium levels, hence potassium-rich foods or potassium supplements are avoided while taking this medicine.

If you suffer from kidney disease or improper functioning of the kidneys. If you suffer from narrowing (stenosis) of the blood vessels to the kidneys.

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