Ibuprofen+Caffeine+Paracetamol / Acetaminophen

When should one not use Ibuprofen+Caffeine+Paracetamol / Acetaminophen

• If you are allergic to paracetamol, ibuprofen or caffeine
• If you have or had a stomach ulcer, perforation or bleeding due to pain killer use
• If you have a history of allergy including asthma, skin rashes or runny nose after taking painkillers
• If you have a history of frequent stomach ulcers or bleeding
• If you are suffering from severe heart failure
• If you have severe kidney or liver problems
• If you are pregnant (especially in the last three months of pregnancy)
• This medicine should not be used in children under 12 years of age

Common side effects of this drug are:

• Nausea
• Vomiting
• Dizziness
• Indigestion
• Stomach pain
• Constipation
• Diarrhoea
• Bloating
• Stomach ulcers
• Exacerbation of asthma

Other General Warnings

• You develop skin allergies like rashes, itching, papules, blisters, etc.
• You have any pre-existing health condition such as kidney or liver function problem, gastrointestinal disorders, hypertension, any kind of blood disorder etc.
• You develop stomach bleeding and ulcers after taking this medicine.
• You have a history or suffering from asthma and nasal allergy.
• You suffer from an immune disorder, where the immune system acts against the body tissues.
• You have smoking habits or you drink too often
• You are pregnant or planning for pregnancy or breastfeeding
• Excessive intake of caffeine (e.g. coffee, tea and some canned drinks) as it should be avoided while taking this medicine

How Does It Work?

• Ibuprofen is a non-steroidal anti-inflammatory drug (NSAIDs) which reduces the production of certain chemicals within the body and thus helps in relieving inflammation and pain
• Paracetamol is an antipyretic and analgesic. It acts on the brain and blocks certain chemical messengers in the brain that tell us we have pain. Paracetamol also reduces your temperature when you have a fever
• Caffeine is a CNS stimulant. It helps in relieving pain and helps in improving the effectiveness of Paracetamol

Interactions with other medicines

• There is limited information available on the interaction of this combination with other medicines. However, as this medicine contains Ibuprofen, Paracetamol and caffeine any interactions seen with these three components when taken alone may occur with Ibuprofen+Caffeine+Paracetamol / Acetaminophen
• Steroids if taken along with Ibuprofen+Caffeine+Paracetamol / Acetaminophen may increase the risk of adverse reactions of the gastrointestinal tract
• Antihypertensives and water pills may diminish the effects of this medicine. Diuretics can increase the risk of kidney toxicity along with this medicine
• Ibuprofen+Caffeine+Paracetamol / Acetaminophen may enhance the effects of anticoagulants, such as Warfarin. Thus, the combination should be avoided. Anti-platelet agents and antianxiety medicines should be used with caution as there is an increased risk of gastrointestinal bleeding
• Cardiac glycosides may exacerbate cardiac failure, reduce GFR and increase plasma glycoside levels. Ibuprofen+Caffeine+Paracetamol / Acetaminophen should not be used for 8-12 days after mifepristone administration as this medicine can reduce the effect of mifepristone
• Cholesterol-lowering medicines like Cholestyramine should be taken with a minimum gap of 2 hours
• Tacrolimus can increase the risk of toxicity to kidneys if taken along with Ibuprofen+Caffeine+Paracetamol / Acetaminophen
• Other medicines such as Chloramphenicol, Ciprofloxacin, Zidovudine, Methotrexate, Metoclopramide, Domperidone and lithium-containing medicines should be used with caution
• Do not take any other medicine containing Paracetamol, Ibuprofen or caffeine

Overdose

Missed a Dose