Fulvestrant

Uses	Breast cancer in postmenopausal women
Therapy	Anti-Neoplastic
Side Effects	Injection site reaction (pain/inflammation), Weakness, Fatigue, Nausea

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Molecule Description

Fulvestrant is an anticancer medicine. It is used to treat post-menopausal women with locally advanced or metastatic breast cancer that is oestrogen receptor positive and HER2 negative. It works by acting as an estrogen receptor antagonist, helping to inhibit the growth of cancer cells. Women of childbearing potential should use effective contraception during treatment with Fulvestrant and for 2 years after the last dose. It is a prescription medicine and must be used as prescribed by a doctor.

Uses

Fulvestrant is primarily used in the treatment of hormone receptor-positive (HR-positive) advanced breast cancer in postmenopausal women.

Contraindications

When should one not use Fulvestrant

Allergy to fulvestrant or any other ingredient of this medicine
Pregnancy
Breastfeeding
Children and Men
Severe liver disease

Side effects

Common side effects of this drug are:

Injection site reaction (pain/inflammation)
Weakness
Fatigue
Nausea
Joint, muscle and back pain
Skin rash
Hot flushes
Headache
A feeling of numbness, tingling or weakness in the legs
Increased level of liver enzymes
Increased level of bilirubin
Urinary Tract Infection (UTI)

Precautions and Warnings

Pregnancy

Fulvestrant is contraindicated during pregnancy

Breast Feeding

Fulvestrant is contraindicated in breastfeeding females.

Driving

Fulvestrant is not expected to affect your ability to drive or use machines. However, if you feel tired and/or weak, do not drive or operate machines and ask your doctor for advice.

Alcohol

No information is available on the interactions of Fulvestrant and alcohol.

Other General Warnings

Talk to your doctor if

You have any problems with your liver or kidneys.
You have low blood platelet count, problems with bleeding, or you use medicine to prevent blood clots (ex., anticoagulants).
You have a personal or family history of osteoporosis (thinning of the bone), or have low bone density, or have a recent history of fracture.
You are a woman of childbearing potential.
Fulvestrant is not recommended for use in children and adolescents.
Suppose you experience any allergic reactions during treatment with Fulvestrant, such as swelling of the face, lips, tongue, or throat, hives, or difficulty with swallowing. In that case, it is crucial to contact your doctor right away. These reactions may occur immediately or a few days after the medicine. Immediate medical attention is necessary to ensure your safety.

Mode of Action

How Does It Work?

Oestrogen (female sex hormone) promotes tumour growth in hormone-sensitive breast cancer. Fulvestrant works by inhibiting some of the actions of oestrogen, which helps to slow the growth of breast cancer tumours.

Dosage

Overdose

You are less likely to receive an overdose of this medicine as it will be given by a doctor or nurse. In the event of an overdose, report to your doctor immediately, even if there are no symptoms.

Missed a Dose

The chances of missing a dose are less as it will be given to you under medical supervision. Still, if you feel a dose has been missed, inform your doctor or nurse.