Follitropin Alfa

Uses	Female infertility, male hypogonadism
Therapy	Drugs For Female Infertility
Side Effects	Pain, irritation, swelling, redness at site of injection

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Molecule Description

Follitropin Alfa is used to treat infertility in women who are not ovulating (producing an egg) properly, male infertility (men with low sperm count). Follitropin alfa is a type of Follicle Stimulating Hormone (FSH) that belongs to a class of hormones called 'gonadotropins' that are involved in reproduction and fertility.

Uses

Female infertility and development of multiple follicles in ovulatory infertile women
Male hypogonadism (low sperm count due to low level of certain hormones secretion)

Contraindications

When should one not use Follitropin Alfa

If you are allergic to Follicle Stimulating Hormone or any of the other ingredients of this medicine.
If you have tumor in brain.
If you have any kind of problems related to reproductive organs such as early menopause, cyst in ovaries, cancer in the womb, breast, damaged testicles etc.

Side effects

Common side effects of this drug are:

Pain, irritation, swelling, redness at site of injection
Headache
Ovarian cysts
Stomach ache
Nausea
Diarrhoea

Precautions and Warnings

Pregnancy

Follitropin Alfa is not recommended to be used during pregnancy.

Breast Feeding

It is not recommended for breastfeeding mothers.

Driving

It is not expected that Follitropin Alfa will affect your ability to drive, but if you do not feel well or are unable to be alert, then avoid driving.

Alcohol

There is limited information about the effects of Follitropin Alfa on alcohol, but avoid taking alcohol in excessive amounts.

Other General Warnings

Talk to your doctor if

You have a history or currently have any kind of blood-related disorder.
You experience leg pain, stomach pain, skin sensitivity such as blistering on the skin on exposure to the sun. The doctor might immediately stop the treatment.
You may develop the risk of Ovarian Hyper-Stimulation Syndrome (OHSS). The symptoms may include lower abdominal pain, breathing difficulty, rapid weight gain, nausea etc. If you experience any of such symptoms talk to your doctor it may require discontinuation of treatment.
You may have a higher risk of being pregnant with more than one child at the same time (multiple pregnancies).
This medicine can make you more prone to miscarriage than average women.
You have a history of blood clotting-related problems or heart stroke. It can make you more likely to have such a problem during the treatment.
You have damaged testicles due to too much FSH in your blood. This medicine might not be effective in such medical conditions. However, if the doctor prescribes then you need to monitor semen analysis for 5 to 6 months after starting treatment.

Mode of Action

How Does It Work?

In women, it acts by developing and ripening several follicles (containing an egg) and inducing the ovulation procedure (releasing an egg from the ovary). In men, it acts by stimulating sperm production.

Interactions

Interactions with other medicines

Follitropin Alfa may interact with other medicines and discuss with your doctor about all the medicines, supplements or herbal preparations you are taking. Also, inform your doctor if you have a planned surgery or vaccination scheduled.
Especially if you are taking any other medicines used in the treatment of female infertility such as clomiphene citrate, as it may increase the effect on ovaries.
Other medicines which reduce your sex hormone levels and stop you from ovulating. In such condition you need higher dose of Follitropin Alfa.

Dosage

Overdose

The doctor and nurse usually give this medicine; the chances of overdose are less because the treatment and the dose will be specific to the patient. However, in case of any discomfort after or during the treatment with this medicine, it should be informed immediately to the doctor.

Missed a Dose

The doctor or nurse usually gives Follitropin Alfa in the hospital or a clinic. Therefore, the chances of missing a dose are less. However, if you feel that a dose has been missed, then please inform your doctor and nurse.

Frequently Asked Questions (FAQs)

It is used to treat infertility in women who are not ovulating (producing an egg) properly by releasing the eggs from the ovary, and male infertility by increasing sperm production in men.

Yes, Follitropin Alfa can be used in males. This medicine helps certain boys in normal sexual development and is also used to increase sperm count.

No, it is not recommended for use in pregnant women.

Yes. Pregnancy following treatment with Follitropin Alfa is more likely to result in a multiple pregnancy (twins or more).