Febuxostat

Molecule Description

Febuxostat used to treat gout, which is associated with an excess of a chemical

called uric acid (urate) in the body.

Uses

Contraindications

Side effects

Precautions and Warnings

Uses of Febuxostat

Mainly in chronic gout
In other hyperuricemic conditions (increased uric acid level in blood) but very rarely

Contraindications of Febuxostat

When should one not use Febuxostat

Do not take it if you have any allergic reactions to Febuxostat.

Side effects of Febuxostat

Common side effects of this drug are:

Nausea, diarrhea, joint pain, headache
Increased liver enzyme levels and rash
Sometimes severe allergic reactions.
Swelling
Hot flushes
Severe skin reaction like blister, shading of skin, rashes (Steven’s Johnson syndrome)

Precautions and Warnings of Febuxostat

Pregnancy

Can I take Febuxostat during pregnancy?

No adequate data about the safety of this medicine in pregnancy. Febuxostat should not be used during pregnancy.

Breast Feeding

Can I take Febuxostat while breastfeeding?

It is unknown whether Febuxostat may pass into human breast milk. Hence it is unsafe to use if you are breastfeeding or if you are planning to breastfeed.

Driving

Can I drive if I have consumed Febuxostat?

If during Febuxostat treatment, you feel dizziness, sleepiness or blurred vision, try to avoid driving.

Alcohol

Can I consume alcohol with Febuxostat?

No known interaction with alcohol. Alcohol is known to increase uric acid levels in the body and can worsen the underlying condition of gout. Avoid excessive consumption of alcohol.

Other General Warnings

Talk to your doctor if

You have heart problems
You have renal disease
You have serious allergic reaction to Allopurinol (a medication used for the treatment of Gout)
You have liver disease
You have thyroid problems
While starting treatment with this medicine, you may get gout flare up. However, continue taking medicine

Mode of Action of Febuxostat

How Does It Work?

Gout is associated with increased uric acid levels
Febuxostat blocks an enzyme in the production of this uric acid and lowers its level

Interactions of Febuxostat

Interactions with other medicines

Medicines used to treat cancer (Mercaptopurine)
Medicines used to reduce immune response (Azathioprine)
Medicines used to treat asthma (Theophylline)

Interactions with food items

No information is available on interactions of this when taken with food, consult your doctor or pharmacist for further information.

Dietary Restrictions of Febuxostat

Avoid meat, beef as these can increase uric acid levels. You are advised to maintain a good amount of water intake while on this medicine.

Dosage of Febuxostat

Overdose

Symptoms of overdose of Febuxostat may include dizziness, nausea, vomiting, rash, headache, etc. Seek emergency medical care immediately.

Missed a Dose

If you missed any dose, take it as soon as you remember. If it is time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose of medicine to compe...

Content Details

WRITTEN BY

Dr. Mahesh Muthe

MBBS

REVIEWED BY

Dr. Ritu Budania

MBBS, MD (Pharmacology)

References

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Last Updated on: 05 Oct 2020 | 10:47 PM (IST)

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