Divalproex Sodium

Uses	Epilepsy, manic episodes
Therapy	Anti-Epileptic
Side Effects	Headache, tremors of hands and feet, abnormal eye movement

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Molecule Description

Divalproex Sodium is an antiepileptic medicine. It is used for the treatment of various forms of epilepsy. Epilepsy is a brain-related disorder that can result in abnormal brain activity, uncontrolled movements, fits, seizures and loss of consciousness. It is also used for the treatment of manic episodes associated with bipolar disorder. Divalproex Sodium contains sodium valproate and valproic acid as the active ingredients. It should be taken as directed by the doctor and in doses and duration as prescribed. Before using this medicine, inform the doctor about your detailed medical history including all the medicines you are currently taking.

Uses

Divalproex Sodium is used in the treatment of various forms of epilepsy and manic episodes associated with bipolar disorder.

Contraindications

When should one not use Divalproex Sodium

If you are allergic to Divalproex Sodium or any ingredients present along with it.
If you have or had acute or chronic hepatitis or have a family history of severe hepatitis, especially medicine related.
If you have a history of liver damage or liver failure.
If you have a history of pancreatitis or damage to the pancreas.
If you are pregnant or planning to become pregnant.
If you have certain disorders that affect metabolism.
If you have conditions that affect the processing of urea (metabolic waste) in the body.
Divalproex Sodium is not meant for children below 3 years of age.

Side effects

Common side effects of this drug are:

Headache
Tremors of hands and feet
Involuntary eye movement
Dizziness
Memory impairment
Nausea

Precautions and Warnings

Pregnancy

You should not take Divalproex Sodium during pregnancy or if you are planning to have a baby. This medicine may cause harm to your baby. If you become pregnant while taking this medicine, discontinue the treatment and consult your doctor immediately. Your doctor may switch you to a safer alternative.

Breast Feeding

Small quantities of Divalproex Sodium pass into the breast milk and can affect your baby if you are breastfeeding the baby. Thus, it is recommended to consult your doctor if you are consuming this medicine and breastfeeding your baby.

Driving

Divalproex Sodium may make you feel sleepy or confused. Individuals must avoid driving or operating heavy machinery immediately after consuming this medicine.

Alcohol

Avoid consuming alcohol while taking Divalproex Sodium as alcohol can affect the concentration of this medicine in your body and can also affect its desired action.

Other General Warnings

Talk to your doctor if

You have or had a liver disease/failure or a recent liver transplant.
You are pregnant or planning to become pregnant or a nursing mother.
You have any pre-existing medical conditions like pancreas, liver or kidney diseases or any kind of blood-related disorder.
You are giving this to children below 3 years.
You experience any sudden changes in mood, sad thoughts, changes in thinking and decision making.

Mode of Action

How Does It Work?

Divalproex Sodium is a combination medicine that acts by increasing the release of certain chemical in the brain that regulates the electrical activity in the brain.

Interactions

Interactions with other medicines

Certain medicines can affect the way Divalproex Sodium works if taken at the same time. Discuss with your doctor about all the medicines, supplements or herbal preparations you are taking. Also, you should inform your doctor if you have a planned surgery or vaccination schedule.
Especially if you are already taking any other anti-epileptic medicines like phenytoin, anti-migraine medicines, antidepressants, pain killers, immunomodulatory medicines, contraceptives, etc.
Use of medicines like warfarin (blood thinners), zidovudine (used in HIV infection), anti-cancer medicines, selegiline, diazepam, quetiapine (used to treat your mental health), propofol (used for anaesthesia) along with Divalproex Sodium may increase their effects.
Concomitant use along with medicines like chloroquine (used in malaria), cimetidine (used in stomach ulcers), rifampicin, meropenem (antibiotics), cholestyramine (used to lower cholesterol) may alter the way this medicine works.

Dosage

Overdose

An overdose of Divalproex Sodium should be immediately reported to your treating doctor or nearby hospital. Always carry the package of the medicine along with you for easy assessment of the severity of an overdose.

Missed a Dose

You should never miss a dose of this medicine as it can aggravate your medical condition. Take the missed dose as soon as possible. Never double dose to compensate for the missed dose.

Frequently Asked Questions (FAQs)

Divalproex Sodium contains sodium valproate and valproic acid as the active ingredients. It is used for the treatment of various forms of epilepsy. It is also used for the treatment of manic episodes associated with bipolar disorder.

This medicine is to be taken with or after food as prescribed by your doctor.

Alcohol can affect the way this medicine works, avoid consuming alcohol while taking this medicine.

No, Divalproex Sodium does not cause addiction. However, it should be taken as per dose and duration prescribed by your doctor. Do not self-medicate as it can lead to severe unwanted effects.