Diacerein+Glucosamine Sulfate Potassium Chloride

Uses	Osteoarthritis
Therapy	Drugs For Osteoarthritis
Side Effects	Headache, tiredness, drowsiness, stomach pain, diarrhoea, nausea, gas, rash

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Molecule Description

Diacerein+Glucosamine Sulfate Potassium Chloride is a combination of glucosamine and diacerein. It is used to treat osteoarthritis of the knee and hip joint. It reduces the pain and swelling of the joint. Diacerein+Glucosamine Sulfate Potassium Chloride works by increasing the cushioning effect between the joints by reducing the friction, thereby making physical movements easy and pain-free. It should not be used for children under 18 years of age.

Uses

Diacerein+Glucosamine Sulfate Potassium Chloride is used to treat osteoarthritis of the knee and hip joints in adult patients.

Contraindications

When should one not use Diacerein+Glucosamine Sulfate Potassium Chloride

If you are allergic to glucosamine, shellfish, diacerein, rhein and substances with similar activity or any other components of Diacerein+Glucosamine Sulfate Potassium Chloride.
If you have or had food pipe or intestinal disease like ulcerative colitis, Crohn's disease.
If you have or had an intestinal obstruction or partial obstruction.
If you have or had liver diseases.
If you have or had stomach pain due to an unknown reason.

Side effects

Common side effects of this drug are:

Headache
Tiredness
Drowsiness
Stomach pain
Diarrhoea
Nausea
Gas
Rash

Precautions and Warnings

Pregnancy

There is limited information available about the effect of Diacerein+Glucosamine Sulfate Potassium Chloride on pregnant women. Hence, pregnant women should not take this medicine to prevent any risk or harm to the unborn baby. Inform your doctor about all the medicines you are taking during pregnancy.

Breast Feeding

Diacerein+Glucosamine Sulfate Potassium Chloride should not be used by breastfeeding mother, as a component of this medicine passes into the breastmilk and may cause harm to the baby. Talk to your doctor if you are a nursing mother.

Driving

Diacerein+Glucosamine Sulfate Potassium Chloride may cause tiredness or drowsiness. If you are affected, do not drive or operate machinery.

Alcohol

You should not consume alcohol while on Diacerein+Glucosamine Sulfate Potassium Chloride. It can alter the effect of this medicine and may increase the side effects. Talk to your doctor if you have a habit of consuming it too often.

Other General Warnings

Talk to your doctor if

You have any other joint disease/conditions to find out the exact cause.
You have or had liver, heart or kidney diseases.
You are an asthmatic patient.
You are pregnant, you think you may be pregnant and breastfeeding.
You have experienced diarrhoea due to Diacerein+Glucosamine Sulfate Potassium Chloride earlier.
You had an electrolyte imbalance or dehydration due to any other medicines in the past.
Diacerein+Glucosamine Sulfate Potassium Chloride should not be used in children below 18 years of age.

Mode of Action

How Does It Work?

Glucosamine is a chemical substance in the body that is an essential part of your joints, including ligaments, tendons, cartilage and synovial fluid. It initiates the synthesis of synovial fluid which keeps the joints lubricated and provides better movement and flexibility. It stops the degradation of cartilage and improves its healing.
Diacerein acts by blocking the actions of a chemical substance called interleukin-1 beta, which causes harm and destructs the cartilage, leading to a degenerative joint disease such as osteoarthritis.

Interactions

Interactions with other medicines

When Diacerein+Glucosamine Sulfate Potassium Chloride is used concomitantly with medicines used as blood thinners such as warfarin can increase the risk of bleeding.
Diacerein+Glucosamine Sulfate Potassium Chloride can decrease the effectiveness of anti-cancer medicine like doxorubicin, etoposide, teniposide when used concomitantly.
Concomitant use of Diacerein+Glucosamine Sulfate Potassium Chloride with antidiabetic medicine such as glipizide, glyburide and metformin may decrease the effect of blood sugar-lowering medicines, in patients with uncontrolled diabetes.
Medicines used to treat acidity should not be used with Diacerein+Glucosamine Sulfate Potassium Chloride as it can decrease the effect of this medicine.
Blood pressure-lowering medicine like furosemide, benzthiazide and also the medicines used to treat heart failure like digoxin can increase the risk of irregular heartbeats, when used along with Diacerein+Glucosamine Sulfate Potassium Chloride.
Discuss with your doctor about any other medicines, herbal preparations and supplements you are taking currently to avoid any possible drug interactions.

Dosage

Overdose

Excess of Diacerein+Glucosamine Sulfate Potassium Chloride can cause adverse effects like headache, dizziness, confusion, joint pain, nausea, vomiting, severe diarrhoea or constipation. If you have taken too much medicine, then contact your doctor or reach out to the nearest hospital immediately.

Missed a Dose

If you have missed taking any dose of Diacerein+Glucosamine Sulfate Potassium Chloride, then take it as soon as you remember. If it's already time for the next dose then skip the missed dose and follow the regular dosing schedule.

Frequently Asked Questions (FAQs)

Yes, Diacerein+Glucosamine Sulfate Potassium Chloride may cause diarrhoea, though not everyone experiences this side effect. Diarrhoea is the most common side effect of this medicine.

If the pain is severe and unbearable you can take painkillers for the first few weeks.

Headache, tiredness, stomach pain, diarrhoea, nausea are a few common side effects that can be seen after taking Diacerein+Glucosamine Sulfate Potassium Chloride. However, these symptoms are usually mild and resolve with time as your body gets used to the medicine.