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Cisplatin

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Molecule Summary

Uses
Cancer
Therapy
Anti-Neoplastic
Side Effects
Nausea, vomiting, decreased sodium level, decreased blood count, kidney problems, hearing problems
3 Step Quality
Assurance
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NPPA
Regulated

Molecule Description

Cisplatin is an anti-cancer medicine. It is used to treat various kinds of metastatic and advanced cancer (that spreads in the body) such as ovarian, testicular, bladder, small cell lung cancer, non-small cell lung cancer, cervical cancer, etc. It acts by killing cancer-causing cells thereby preventing the spread of cancer cells. This medicine will be given by a doctor or nurse at a hospital or clinic.

Uses

  • Testicular cancer
  • Ovarian cancer
  • Bladder cancer
  • Small cell and non-small cell lung cancer
  • Cervical cancer

Contraindications

When should one not use Cisplatin

  • If you are allergic to cisplatin, platinum-containing products, or any other ingredient of this medicine.
  • If you have pre-existing kidney disease or hearing disorder.
  • If you have suppressed bone marrow or decreased bone marrow activity.
  • If you are dehydrated.
  • If you have recently taken the yellow fever vaccine.
  • If you are breastfeeding.

Side effects

Common side effects of this drug are:

  • Nausea
  • Vomiting
  • Decreased sodium levels
  • Decreased blood count
  • Bone marrow failure
  • Infection
  • Altered heart rate and rhythm
  • Kidney problems
  • Hearing problems

Precautions and Warnings

Pregnancy

Pregnancy

Cisplatin may cause harm to the unborn baby if used during pregnancy. Thus, this medicine should not be used during pregnancy unless advised by your doctor after assessing the risk and need.

Breast Feeding

Breast Feeding

Cisplatin passes into the breast milk, thus it should not be used by a nursing mother.

Driving

Driving

If you experience dizziness or nausea after taking this medicine, it is advised to avoid driving.

Alcohol

Alcohol

You should avoid consuming alcohol while on Cisplatin. Talk to your doctor if you consume it often.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You are using aluminium containing medicine, devices, or sets.
  • You have kidney disease or are on any other medicine that alters kidney function.
  • You experience or have any hearing, movement or vibration loss.
  • You are allergic to this medicine, or any other undesired side effects.
  • You have or had liver disease.
  • You have or had bone marrow failure.
  • You are pregnant, planning pregnancy, or breastfeeding.
  • You have low haemoglobin and low blood count.

Mode of Action

How Does It Work?

Cisplatin works by stopping the growth and multiplication of cancer cells. The growth and multiplication of cells take place through DNA, a genetic material. Cisplatin damages the DNA by binding it onto the cancer cells and thus prevents growth and multiplication.

Interactions

Interactions with other medicines

  • Some medicines can affect the way Cisplatin works, or Cisplatin itself can reduce the effectiveness of other medicines taken at the same time.
  • Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
  • Especially if you are taking other pain killers, blood thinners, anti-allergic, anti-seizure (fit) medicine, immunomodulatory medicine, and antibiotics.
  • Tell your doctor if you are taking or have recently taken any live vaccine, such as the yellow fever vaccine.

Dosage

Overdose

Your doctor or nurse will give this medicine so it is unlikely that you overdose on this medicine. Overdose of Cisplatin may cause kidney or liver damage, hearing loss, vision loss, nausea, vomiting and bone marrow suppression.

Missed a Dose

You will be monitored by your doctor or nurse as to when Cisplatin should be given to you. It is unlikely that the dose will be missed. However, if you think your doctor or nurse might have missed a dose, inform them.

Frequently Asked Questions (FAQs)

Cisplatin is an anti-cancer medicine used to treat various types of cancers. It is used to treat advanced and metastatic (spreading) cancer such as bladder, ovarian, cervical, testicular, etc.

Yes, nephrotoxicity is a common side effect of Cisplatin. It is advised to stay hydrated while on this medicine. Talk to your doctor for more information.

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