Cisplatin
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Molecule Summary
| Uses | Cancer |
| Therapy | Anti-Neoplastic |
| Side Effects | Nausea, vomiting, decreased sodium level, decreased blood count, kidney problems, hearing problems |
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Regulated
Molecule Description
Cisplatin is an anti-cancer medicine. It is used to treat various kinds of metastatic and advanced cancer (that spreads in the body) such as ovarian, testicular, bladder, small cell lung cancer, non-small cell lung cancer, cervical cancer, etc. It acts by killing cancer-causing cells thereby preventing the spread of cancer cells. This medicine will be given by a doctor or nurse at a hospital or clinic.
Uses
- Testicular cancer
- Ovarian cancer
- Bladder cancer
- Small cell and non-small cell lung cancer
- Cervical cancer
Contraindications
When should one not use Cisplatin
- If you are allergic to cisplatin, platinum-containing products, or any other ingredient of this medicine.
- If you have pre-existing kidney disease or hearing disorder.
- If you have suppressed bone marrow or decreased bone marrow activity.
- If you are dehydrated.
- If you have recently taken the yellow fever vaccine.
- If you are breastfeeding.
Side effects
Common side effects of this drug are:
- Nausea
- Vomiting
- Decreased sodium levels
- Decreased blood count
- Bone marrow failure
- Infection
- Altered heart rate and rhythm
- Kidney problems
- Hearing problems
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You are using aluminium containing medicine, devices, or sets.
- You have kidney disease or are on any other medicine that alters kidney function.
- You experience or have any hearing, movement or vibration loss.
- You are allergic to this medicine, or any other undesired side effects.
- You have or had liver disease.
- You have or had bone marrow failure.
- You are pregnant, planning pregnancy, or breastfeeding.
- You have low haemoglobin and low blood count.
Mode of Action
How Does It Work?
Cisplatin works by stopping the growth and multiplication of cancer cells. The growth and multiplication of cells take place through DNA, a genetic material. Cisplatin damages the DNA by binding it onto the cancer cells and thus prevents growth and multiplication.
Interactions
Interactions with other medicines
- Some medicines can affect the way Cisplatin works, or Cisplatin itself can reduce the effectiveness of other medicines taken at the same time.
- Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
- Especially if you are taking other pain killers, blood thinners, anti-allergic, anti-seizure (fit) medicine, immunomodulatory medicine, and antibiotics.
- Tell your doctor if you are taking or have recently taken any live vaccine, such as the yellow fever vaccine.
Dosage
Overdose
Your doctor or nurse will give this medicine so it is unlikely that you overdose on this medicine. Overdose of Cisplatin may cause kidney or liver damage, hearing loss, vision loss, nausea, vomiting and bone marrow suppression.
Missed a Dose
You will be monitored by your doctor or nurse as to when Cisplatin should be given to you. It is unlikely that the dose will be missed. However, if you think your doctor or nurse might have missed a dose, inform them.
Frequently Asked Questions (FAQs)
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