Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen
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Molecule Summary
| Uses | Musculoskeletal pain, swelling and spasm |
| Therapy | Analgesic/Antipyretic, Muscle Relaxant |
| Side Effects | Diarrhoea, vomiting, indigestion, dizziness, drowsiness, abdominal pain, sweating |
Medicines
available
19k pincodes
Molecule Description
Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen is a commonly prescribed medication for relieving pain, swelling, and inflammation related to muscles, joints, and bones. It is also effective in managing pain after surgeries or operations. This makes it useful for conditions like muscle strain, sprains, back pain, arthritis, and post-operative pain.
This medicine is a combination medicine containing three active ingredients: paracetamol, chlorzoxazone, and ibuprofen. Paracetamol acts as a pain reliever and fever reducer, ibuprofen decreases inflammation and swelling, and chlorzoxazone functions as a muscle relaxant. Together, they provide faster and more effective relief from musculoskeletal pain.
Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen is used to treat joint pain, muscle stiffness, sports injuries, and pain caused by overexertion. It can be taken with or without food, but it is recommended to take it with food to prevent stomach upset. Never exceed the advised dose and duration. If your pain persists, consult your doctor before continuing.
The choice of medication and dose should always be determined by your doctor, based on your condition and overall health.
Possible side effects of Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen may include dizziness, nausea, stomach upset, drowsiness, or mild changes in liver enzymes. To stay safe, always inform your doctor if you are pregnant, breastfeeding, or planning pregnancy, and share details about any other medicines, supplements, or medical conditions before starting this medication.
Uses
- Pain-related to muscle, joint and bones.
- Sports injury, sprain and strain.
- Postoperative pain and trauma.
Contraindications
When should one not use Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen
- If you are allergic to paracetamol, ibuprofen, chlorzoxazone or any component of this medicine.
- If you are using any other medication containing paracetamol or ibuprofen.
- If you have a history of allergic asthma or breathing issue due to the use of pain killers.
- If you have ulcers or are prone to have ulcers in the stomach and intestine.
- If you have any disorders associated with blood clotting.
- If you have severe heart, kidney or liver-related disorders.
- If you are using other pain killers similar to Ibuprofen like celecoxib, and rofecoxib.
- If you are in the third trimester of your pregnancy.
- If you have porphyria, a blood disorder characterised by severe abdominal pain.
Side effects
Common side effects of this drug are:
- Diarrhoea
- Vomiting
- Indigestion
- Dizziness
- Drowsiness
- Abdominal pain
- Sweating
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- You have severe kidney or liver-related disorders.
- You are using any other pain killers containing paracetamol.
- You are an elderly patient with a risk of side effects.
- You have asthma or have a history of asthma.
- You have systemic lupus erythematosus, a disorder characterised by severe weakness, joint pain and rash.
- You have high blood pressure or any heart-related disorders.
- You develop ulcers or bleeding in the digestive system.
- You experience redness and skin peeling all over the body or develop Stevens-Johnson syndrome, characterised by flu-like symptoms, rash and blisters.
Mode of Action
How Does It Work?
- Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen works by the combined action of its three components.
- Ibuprofen and Paracetamol inhibit the synthesis of prostaglandins which are responsible for causing pain, swelling and inflammation, thus offering anti-inflammatory properties.
- Chlorzoxazone is a muscle relaxant which works by blocking the signals of painful sensation through the nerve to the brain and reduces pain and stiffness.
Interactions
Interactions with other medicines
- Certain medicines can affect the way Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen works or Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen itself can interfere with the action of other medicines if taken along.
- Tell your doctor about all the medicines, supplements and herbals you are currently taking or might take to avoid any possible interaction.
- Concomitant use of Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen with other medicines containing paracetamol, aspirin or other painkillers can increase the risk of side effects.
- Use of Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen with blood thinners like warfarin can increase the risk of bleeding.
- Medicine used to treat high blood pressure like enalapril, quinapril, losartan, telmisartan, when used along with Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen, can increase the risk of kidney problems.
- Digoxin, a medicine used to treat heart failure, when used along with this medicine, can worsen the heart's condition. Cyclosporine, tacrolimus and methotrexate, if taken along with Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen, can increase the risk of a kidney-related problem.
- Mifepristone, a medicine acting on the uterus, should not be used with this medicine as the effect of Mifepristone may be decreased.
- Other medicines such as certain steroids, medicines used for the brain-related condition, certain antibiotics and certain antiviral medicines should be used cautiously.
Interactions with food items
Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen should be taken with or after meals to avoid nausea or vomiting. Avoid spicy and fatty foods.
Dosage
Overdose
Symptoms of overdose of Chlorzoxazone+Ibuprofen+Paracetamol / Acetaminophen include vomiting, diarrhoea, ringing in the ear, extreme weakness, and shortness of breath. If you think you have taken an excessive dose of this medicine, contact your doctor immediately or visit the nearest hospital. A significant overdose can also cause damage to the liver.
Missed a Dose
If you have missed any dose of medicine, take it as soon as you remember. If it's time for your next dose, skip the missed dose and continue with your regular dose schedule. Do not take a double dose of this medicine to compensate for the missed one.
Frequently Asked Questions (FAQs)
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References:
- Paracetamol tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 3rd Jun 2026]
- Ibuprofen tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [cited 3rd Jun 2026]
- Rogers R, Meier A, Weinberg L, et al. The role of the microbiome in inflammatory bowel disease. PMCID: PMC6513919 [Internet]. 2025 [cited 3rd Jun 2026].
- U.S. National Library of Medicine. Abacavir [Internet]. MedlinePlus. 2025 [cited 3rd Jun 2026].
- U.S. National Library of Medicine. Acetaminophen [Internet]. MedlinePlus. 2025 [cited 3rd Jun 2026]
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