Chloroquine
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Molecule Description
Chloroquine belongs to a group of medicines called anti-malarials. It can be taken in certain parts of the world to help prevent malaria.
Uses
- It is used in the treatment of malaria (caused by a parasite – common symptoms include chills and high fever)
- Infection and pus formation in the liver due to parasitic infection (Amoebic Hepatitis and Liver Abscess)
Contraindications
When should one not use Chloroquine
- Allergy to Chloroquine or any ingredients of the medicine
- Amiodarone, a medicine used to treat abnormal heart rhythms should not be used along with Chloroquine
Side effects
Common side effects of this drug are:
- Skin rashes, swelling of lips, face and tongue
- Headache, feeling dizzy, unintentional muscle movements
- Hearing loss, vision problems, increased sensitivity to light
- Hair loss and changes in hair color
- Abnormal heart rhythms, low blood pressure
- Mood changes, depression, confusion, sleeplessness
Precautions and Warnings
Pregnancy
Breast Feeding
Driving
Alcohol
Other General Warnings
Talk to your doctor if
- Seizures (fits)
- A genetic disorder causing purplish skin rashes due to defect in blood formation (porphyria)
- Scaly rashes of the skin (psoriasis)
- A type of muscle weakness (myasthenia gravis)
- A genetic disorder causing increased breakdown of red blood cells (G6PD – Glucose 6 Phosphate Dehydrogenase deficiency)
- Rabies vaccine or thyroid hormone reduces the effectiveness of Chloroquine
Mode of Action
How Does It Work?
Chloroquine acts by killing sensitive malaria parasites at different stages of their development in our red blood cells. This medicine gets stored in the liver and hence is effective against liver parasites like Entamoeba (Amoebiasis). Chloroquine also suppresses certain components of the immune system and inflammation and are useful in conditions like rheumatoid arthritis.
Interactions
Interactions with other medicines
- Amiodarone – to treat irregular heartbeats
- Use with caution
- Praziquantel (used to treat worm infections – tapeworm, etc.)
- Digoxin (irregular heartbeats)
- Anti-seizure medications (Phenytoin, Carbamazepine)
- Cyclosporin (suppresses immune system)
- Kaolin (treats diarrhea)
- Medicines used to reduce stomach acid (Cimetidine, Omeprazole or antacids like aluminum, magnesium, etc.)
- Ciprofloxacin (antibiotic)
- Medicines for depression, thyroid or heart disease
Interactions with food items
Take Chloroquine tablets with food or immediately after a meal with a glass of water.
Dosage
Overdose
Accidental overdose may not be life-threatening. But if you feel any discomfort or experience symptoms such as abnormal heartbeats, feeling dizzy, or any allergic reactions, consult your doctor.
Missed a Dose
Take the missed dose as you remember. Skip the missed dose; do not take extra medicine or double dose to compensate for the missed dose. Ideally, you should have a 12-hour gap between two doses.
Frequently Asked Questions (FAQs)
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