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Ceritinib

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Molecule Summary

Uses
Non-small cell lung cancer
Therapy
Anti-Neoplastic
Side Effects
Anaemia, diarrhoea, nausea, vomiting, abdominal pain, constipation, decreased appetite, skin rash
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Molecule Description

Ceritinib belongs to the class of medicines called kinase inhibitors. It is used to treat ALK-positive adults with metastatic non-small cell lung cancer. It is a prescription medicine and must be taken as advised by the doctor. Tell your doctor if you have heart disease, liver or kidney problems, or if you are taking any antibiotics. Other medications can affect or be affected by Ceritinib, so inform your doctor about all the ongoing medicines beforehand.

Uses

  • Metastatic Non-small cell lung cancer

Contraindications

When should one not use Ceritinib

If you are allergic to ceritinib or any ingredients of this medicine.

Side effects

Common side effects of this drug are:

  • Decreased appetite
  • Anaemia
  • Diarrhoea
  • Nausea
  • Vomiting
  • Abdominal pain
  • Constipation
  • Skin rash

Precautions and Warnings

Pregnancy

Pregnancy

Limited information is available on the use of Ceritinib during pregnancy. However, it is advisable not to use it in pregnancy.

Breast Feeding

Breast Feeding

Do not breastfeed during treatment with Ceritinib and for 2 weeks after stopping this medicine.

Driving

Driving

Avoid driving if you feel less alert after taking this medication.

Alcohol

Alcohol

No information is available on the interactions between Ceritinib and alcohol.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You are allergic to any of the ingredients
  • You have lung, liver or kidney problems
  • You have a habit of smoking or drinking alcohol
  • You are pregnant or plan to get pregnant
  • You are diabetic
  • You have any heart-related problems
  • It may impair the ability to drive or operate machines
  • Use effective contraception methods during treatment

Mode of Action

How Does It Work?

The Anaplastic Lymphoma Kinase (ALK) is a protein that plays an important role in cell signalling. It is involved in various cellular processes, including cell growth, division, and differentiation. Ceritinib works by binding to the ALK protein, preventing its activity, and thereby stopping the growth and spread of cancer cells.

Dosage

Overdose

In the event of an overdose, report to your doctor immediately.

Missed a Dose

If you have missed a dose of Ceritinib, then take it as soon as you remember. If it is almost time for the next dose, then skip the missed dose and continue with your regular dosing schedule.

Frequently Asked Questions (FAQs)

Approximately 80% to 85% of lung cancers belong to non-small cell lung cancer NSCLC type.

NSCLC (non-small cell lung cancer) has three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Although these subtypes originate from different lung cells, they are grouped together as NSCLC because they are often treated and have similar outlooks (prognoses). These are different from other types of lung cancer called small cell lung cancer.

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