Cefazolin

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Molecule Description

Cefazolin is an antibiotic that is useful in the treatment of infections caused by bacteria.

Uses

This medicine is primarily utilized in the treatment of pneumonia, biliary tract infections, infection of the inner walls of the heart (endocarditis), bacterial skin infection (cellulitis), urinary tract infections and infections in joints. It can also be used before and during certain surgeries to prevent infection.

Contraindications

When should one not use Cefazolin

If you have Penicillin allergy (hypersensitivity).

Side effects

Common side effects of this drug are:

Loss of appetite
Nausea
Vomiting or diarrhea
Headache
Dark urine
Easy bruising
Irregular heartbeat
Fits, weakness
Yellowing of eyes or skin
Mental or mood changes (such as confusion)

Precautions and Warnings

Pregnancy

It is advised to consult a doctor before taking this medicine.

Breast Feeding

It may pass into breast milk and may have undesirable effects on a nursing baby, and the baby should be monitored closely to observe if they show any side effects such as diarrhea or thrush. Consult your doctor before breastfeeding.

Driving

The drug has a rare side effect of causing dizziness and drowsiness. Hence, you should consult a doctor if you perform some activities that require focus, such as driving.

Alcohol

The interaction of Cefazolin with alcohol is unknown. So, you should consult a doctor before consuming any alcohol.

Other General Warnings

Talk to your doctor if

Talk to your doctor if:
You have kidney disease or swelling of intestine (colitis)
You experience dark urine, easy bruising/ bleeding, irregular heartbeat
It may interfere with any birth control methods, so consult your doctor before you take this medication

Mode of Action

How Does It Work?

It mainly kills the bacteria unlike other antibiotics which stop bacterial growth. It inhibits cell wall biosynthesis which leads to the bacteria to lyse as their cell walls are continuously broken down.

Interactions

Interactions with other medicines

Aminoglycoside antibiotics (like Tobramycin, Gentamicin)
Blood thinners (Warfarin)
Chloramphenicol
Birth control pills, patch or ring
Antibiotics (such as Rifampin, Rifabutin)

Interactions with food items

No relevant information.

Dosage

Overdose

Symptoms of overdose include difficulty in breathing and seizures. If there has been an overdose, call a doctor immediately.

Missed a Dose

If you miss a dose, follow the regular dosage schedule but do not double the dose.

Frequently Asked Questions (FAQs)

This drug is bactericidal, which means that it can kill the bacteria, rather than prevent its growth in the infected area. Its usage in combination with other antibiotics can be lethal.

Yes, the drug is administered to the pregnant woman to help alleviate any cause of infection. It is secreted naturally in breast milk, so it should be given with caution to the nursing mother.

This drug can affect the central nervous system; it cannot be utilized for the treatment of meningitis.

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References:

Webmd. cefazolin. [Accessed 17.sept .2019] (online)

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