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Buprenorphine

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Molecule Summary

Uses
Severe pain, Opioid de-addiction
Therapy
Analgesic For Severe Pain
Side Effects
Headache, constipation, stomach pain, excessive sweating, sleep disturbances.
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Molecule Description

Buprenorphine is a strong painkiller used to treat severe pain in adults. Buprenorphine belongs to a class of opioid medicine that reduces severe pain by changing the normal response of the brain and nervous system towards pain.

Uses

  • Severe pain
  • De-addiction therapy for those addicted to narcotics

Contraindications

When should one not use Buprenorphine

If you're allergic to buprenorphine or any other ingredients present in the medicine

Side effects

Common side effects of this drug are:

  • Stomach pain
  • Constipation
  • Headache
  • Sleep disturbances
  • Blurred vision
  • Excessive sweating

Precautions and Warnings

Pregnancy

Pregnancy

No, Buprenorphine is not safe to be taken during pregnancy as it is known to cause withdrawal symptoms in the newborn. However, if you are pregnant or planning to be pregnant while taking Buprenorphine, consult your doctor immediately.

Breast Feeding

Breast Feeding

Avoid taking Buprenorphine while breastfeeding as it is found to be excreted in breast milk. Consult your doctor before starting any medicine. If you notice your child sleeping more than usual, facing any breathing difficulty, or can't suckle, immediately consult your doctor.

Driving

Driving

No, it isn't safe to drive when taking Buprenorphine as it is known to cause mental and physical impairment required while driving a car. It may induce sleepiness, dizziness, confusion, blur your vision and impair your ability to think and concentrate and hence not recommended to drive a vehicle when under this medication.

Alcohol

Alcohol

No, alcohol must be avoided with Buprenorphine as it increases sleepiness and symptoms of severe side effects that can be life-threatening.

Other General Warnings

Other General Warnings

Talk to your doctor if
  • You are taking medications before starting Buprenorphine.
  • You have severe breathing problems.
  • You have suffered any head injury or brain disorders.
  • You have liver or kidney problems.
  • You suffer from pancreas disease.

Mode of Action

How Does It Work?

Buprenorphine reduces pain by changing the normal response of the brain and nervous system towards pain. It also prevents the withdrawal symptoms in patients undergoing de-addiction from opioids by producing similar effects as an opioid.

Interactions

Interactions with other medicines

  • Buprenorphine may adversely interact with medicines to treat depression, such as paroxetine, to cause fits and seizures and may even lead to coma (as the brain activity is suppressed significantly).
  • Buprenorphine may cause breathing difficulties, increased sleepiness, and even coma when taken along with medicines to treat pain (morphine), medicines to treat cough (codeine) and medicines for allergy.
  • Buprenorphine becomes less effective when taken with medicines to treat tuberculosis like rifampicin.

Interactions with food items

  • Buprenorphine may interact adversely with:
  • St. John's Wort (herbal medicine for depression)
  • Tryptophan containing dietary supplements (milk, cheese, oats, chicken, tuna fish and nuts)

Dosage

Overdose

  • Symptoms of an overdose of Buprenorphine can be fatal and include increased sleepiness, difficulty breathing, blurred vision, dizziness, and even coma. If you happen to take too much of Buprenorphine, reach out to your doctor or the nearest hospital immediately.

Missed a Dose

Buprenorphine must be taken as prescribed by your doctor. If you miss a dose, take it just when you remember it. However, you should skip a missed dose when enough time has passed, and it is time for your next dose. Do not take a double dose of Buprenorphine to make up for the missed dose. This may lead to overdosing.

Frequently Asked Questions (FAQs)

No, Buprenorphine should not be given to children below 16 years as the safety and efficacy of Buprenorphine in children have not been studied and lack required data.

Take precaution while getting up from a lying position as taking this medicine may cause dizziness, lightheadedness, and fainting when you get up quickly from a lying position. To prevent these symptoms, get from bed slowly and rest your feet on the floor for a few minutes before standing up.

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