Amlodipine+Perindopril

Uses	High blood pressure
Therapy	Anti-Hypertensive
Side Effects	Headache, dizziness, cough, swelling

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Molecule Description

Amlodipine+Perindopril is a medicine used to treat high blood pressure. It contains two active medicines, perindopril and amlodipine, which work together to relax and widen the blood vessels. This helps blood flow more easily and lowers blood pressure, reducing strain on the heart and blood vessels. This medicine is usually prescribed when blood pressure is not adequately controlled with a single medicine. Even if you feel normal, it is important to continue taking Amlodipine+Perindopril regularly, as high blood pressure often does not cause noticeable symptoms. Stopping the medicine suddenly may cause your blood pressure to rise again. Amlodipine+Perindopril should be taken exactly as advised by your doctor, preferably at the same time every day. Some people may experience side effects such as dizziness, headache, cough, or swelling of the feet or ankles, especially at the beginning of treatment. Getting up slowly from sitting or lying positions can help reduce dizziness. This medicine should not be used during pregnancy or while breastfeeding. Inform your doctor if you have kidney disease, diabetes, heart problems, or are taking other medicines, especially diuretics or potassium supplements. Regular follow-up and blood pressure monitoring are important to ensure safe and effective treatment.

Uses

Amlodipine+Perindopril is used to treat hypertension (high blood pressure).

Contraindications

When should one not use Amlodipine+Perindopril

If you are allergic to perindopril, amlodipine, other ACE inhibitors, or any other ingredient of Amlodipine+Perindopril.
If you have a history of swelling under the skin (angioedema) with or without the use of medicines called ACE inhibitors.
If you have diabetes and are taking a medicine that contains Aliskiren.

Side effects

Common side effects of this drug are:

Headache
Dizziness
Cough
Swelling

Precautions and Warnings

Pregnancy

Amlodipine+Perindopril should not be taken during pregnancy unless recommended by the doctor after assessing the need and the risk. If pregnancy is detected during treatment with this medicine, discontinue the use of this medicine as soon as possible.

Breast Feeding

Amlodipine+Perindopril is not advised for breastfeeding mothers. This medication passes into breastmilk in trace levels, which may harm your baby, particularly if he or she is a newborn or was born prematurely. Please contact your doctor about a safer alternative.

Driving

Please avoid driving if you experience any effects after taking this medicine that may affect your ability to drive safely.

Alcohol

Avoid drinking alcohol while taking Amlodipine+Perindopril as it could lower your blood pressure and cause dizziness or fainting.

Other General Warnings

Talk to your doctor if

You are pregnant or plan on becoming pregnant.
You are taking medicines called ACE inhibitors like captopril, and enalapril and develop symptoms like swelling of the face, legs, hands, lips, tongue, glottis, and larynx.
You have narrowing or blockage of the blood vessels that supply blood to the heart (coronary artery disease).
You develop heart-related chest pain after taking this medicine.
You have low fluid or salt due to severe diarrhoea/vomiting, low dietary salt intake, dialysis, or prolonged use of diuretics.
You have a narrowing of the aortic valve of the heart (aortic stenosis).
You are scheduled for surgery with anaesthesia.
You have kidney disorders.
You have diabetes.
You are taking medicines called potassium-sparing diuretics, potassium supplements, and/or potassium-containing salt substitutes.

Mode of Action

How Does It Work?

Amlodipine+Perindopril relaxes blood vessels, allowing blood to flow more freely throughout the body. This decreases your blood pressure and lowers your chances of suffering a stroke, heart attack, or kidney issues in the future.

Interactions

Interactions with other medicines

Some medicines can affect the way Amlodipine+Perindopril works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
Inform your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
Particular care should be taken if you are taking medicines for treating fluid accumulation (diuretics), mental disorders (lithium), abnormal/high cholesterol (simvastatin), preventing organ rejection after a transplant (cyclosporine), abnormal/irregular heartbeat (diltiazem), fungal infections (itraconazole).
There is a risk of increased blood potassium levels when Amlodipine+Perindopril is used along with potassium-sparing diuretics (spironolactone, amiloride), potassium supplements, or other medicines that can increase serum potassium (indomethacin, heparin, cyclosporine).
Nitritoid reactions (redness of the face, nausea, vomiting, low blood pressure) may occur when this medicine is used with injectable gold (used to treat arthritis symptoms).
When Amlodipine+Perindopril is used together with non-steroidal anti-inflammatory medicines (used for treating pain, redness, and swelling), there is a risk of kidney damage, especially in the elderly who have low fluid volume or in individuals with kidney disorders.

Interactions with food items

Amlodipine+Perindopril can be taken with or without food.
Avoid grapefruit and grapefruit juice, as they may increase the effect of amlodipine and cause excessive lowering of blood pressure.
Limit high-salt foods, as excess salt can reduce the blood-pressure-lowering effect.
Be cautious with potassium-rich foods or salt substitutes containing potassium, especially if advised by your doctor.
Maintain a balanced, heart-healthy diet while taking this medicine.

Dosage

Overdose

An overdose of Amlodipine+Perindopril can lead to low blood pressure (hypotension). The most common side effect of an overdose is low blood pressure, which can result in dizziness or fainting. If this happens, lying down with your legs elevated can help. If you have taken too much of this medicine and are experiencing any of these side effects, seek emergency medical assistance.

Missed a Dose

If you miss a dose of Amlodipine+Perindopril, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Frequently Asked Questions (FAQs)

Some people may feel dizzy, especially when starting the medicine or when standing up suddenly. Getting up slowly can help reduce this effect.

No, do not stop taking the medicine on your own, even if your blood pressure is controlled. Always consult your doctor before making any changes to the dose or stopping the treatment.